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ChemicalBook >> CAS DataBase List >>2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-

2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-

2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Structure
2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- structure
CAS No.
2647503-57-7
Chemical Name:
2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-
Synonyms
2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-
CBNumber:
CB712459413
Molecular Formula:
C24H31ClF2N6O2
Molecular Weight:
508.99
MDL Number:
MOL File:
2647503-57-7.mol
Last updated:2025-04-18 09:52:34
Request For Quotation

2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Properties

Boiling point 640.1±65.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
form Solid
pka 15.14±0.29(Predicted)
color White to off-white

2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Chemical Properties,Uses,Production

Uses

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM[1].

in vivo

CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model[1].

Animal Model:OCI-Ly1 DLBCL xenograft model (female SCID mice)[1].
Dosage:15 mg/kg.
Administration:PO, single dose.
Result:Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.
Animal Model:Female Balb/C mice[1].
Dosage:1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
Administration:IV and PO
Result:Demonstrated moderate clearance (CL 20 mL min?1 kg?1) with mean oral bioavailability of 54%.

References

[1] Benjamin R Bellenie, et al. Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. J Med Chem. 2020 Apr 23;63(8):4047-4068. DOI:10.1021/acs.jmedchem.9b02076

2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1615 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5002 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
Supplier Advantage
Aladdin Scientific 		58
Jilin Province Woda Biotechnology Co., Ltd. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
2H-Benzimidazol-2-one, 5-[[5-chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- 2647503-57-7 C24H31ClF2N6O2