N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN
- CAS No.
- 112525-72-1
- Chemical Name:
- N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN
- Synonyms
- STK367969;Boc-DL-tryptophan;N-α-Boc-DL-Tryptophan;(tert-Butoxycarbonyl)tryptophan;N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN;N-(tert-Butoxycarbonyl)-DL-tryptophan >(tert-Butoxycarbonyl)tryptophan - [B92214];N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN USP/EP/BP;N-(tert-Butoxycarbonyl)-DL-tryptophan;3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoicaci
- CBNumber:
- CB7129966
- Molecular Formula:
- C16H20N2O4
- Molecular Weight:
- 304.34
- MDL Number:
- MFCD00190836
- MOL File:
- 112525-72-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-(tert-Butoxycarbonyl)-DL-tryptophan | B4891 | 1G | $23 |
| N-(tert-Butoxycarbonyl)-DL-tryptophan | B4891 | 5G | $71 |
| (tert-Butoxycarbonyl)tryptophan 98% | B92214 | 1g | $17 |
| (tert-Butoxycarbonyl)tryptophan 98% | B92214 | 5g | $21 |
| (tert-Butoxycarbonyl)tryptophan 98% | B92214 | 10g | $22 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933.99.8290 |
N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4891 | N-(tert-Butoxycarbonyl)-DL-tryptophan | 112525-72-1 | 1G | $23 | 2026-04-30 | Buy |
| TCI Chemical | B4891 | N-(tert-Butoxycarbonyl)-DL-tryptophan | 112525-72-1 | 5G | $71 | 2026-04-30 | Buy |
| Synthonix | B92214 | (tert-Butoxycarbonyl)tryptophan 98% | 112525-72-1 | 1g | $17 | 2026-05-06 | Buy |
| Synthonix | B92214 | (tert-Butoxycarbonyl)tryptophan 98% | 112525-72-1 | 5g | $21 | 2026-05-06 | Buy |
| Synthonix | B92214 | (tert-Butoxycarbonyl)tryptophan 98% | 112525-72-1 | 10g | $22 | 2026-05-06 | Buy |
N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN Chemical Properties,Uses,Production
Synthesis
24424-99-5
54-12-6
![N-[(tert-Butoxy)carbonyl]-D-tryptophan](/CAS/GIF/5241-64-5.gif)
5241-64-5
Step 3. General procedure for the preparation of BOC-D-tryptophan. To a solution of water (54 mL) containing NaOH (2.2 g, 55.0 mmol) was added DL-tryptophan (10.0 g, 49.0 mmol) and 1,4-dioxane (36 mL). Subsequently, di-tert-butyl dicarbonate (Boc2O, 10.7 g, 49.1 mmol) was added slowly and dropwise to the above mixture. The reaction mixture was stirred at room temperature for 24 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and the completion of the reaction was indicated by the unfolding of dichloromethane: methanol = 10:1 and an Rf value of 0.5. The reaction mixture was adjusted to pH 6.0 with solid citric acid and subsequently extracted with ethyl acetate (EtOAc, 30 mL x 3). The organic layers were combined, dried and concentrated to give a colorless oil. The residue was washed with petroleum ether (100 mL) and filtered, and the filter cake was further washed with petroleum ether and dried to give BOC-D-tryptophan (14.8 g, 99.0% yield) as a final white solid.
References
[1] Patent: WO2014/14937, 2014, A1. Location in patent: Paragraph 0125; 0128
[2] Patent: CN104876930, 2017, B. Location in patent: Paragraph 0054-0056
[3] Patent: US2010/297756, 2010, A1
[4] Chemistry - A European Journal, 2015, vol. 21, # 51, p. 18589 - 18593
[5] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 140 - 153
N-TERT-BUTOXYCARBONYL-DL-TRYPTOPHAN Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9540 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Fortuna Chemical Co.,Ltd | +86-2759207851; +8618007136271 | hk@fortunachem.com | China | 6008 | 58 |
| DONBOO AMINO ACID COMPANY | +8618051385538 | donboo@donboo.com | China | 9363 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14100 | 59 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| GL Biochem(Binhai) Ltd. | 58 |
| Dideu Industries Group Limited | 58 |
| Finetech Industry Limited | 58 |
| Nextpeptide Inc | 58 |
| Aladdin Scientific | 58 |
| Wuhan Fortuna Chemical Co.,Ltd | 58 |
| DONBOO AMINO ACID COMPANY | 58 |
| Adamas Reagent, Ltd. | 59 |
