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Rosiglitazone

Description References
Rosiglitazone
Rosiglitazone structure
CAS No.
122320-73-4
Chemical Name:
Rosiglitazone
Synonyms
AVANDIA;BRL 49653;roiglitazone;ROSIGLIAZONE;ROSIGLITAZONE;ROSIGLITAZONEHCL;ROSIGLITAZONE 99%;ROSIGLITAZONE HCL;ROEIGLITAZONEMALEATE;Rosiglitazone, >=98.5%
CBNumber:
CB7133275
Molecular Formula:
C18H19N3O3S
Formula Weight:
357.43
MOL File:
122320-73-4.mol

Rosiglitazone Properties

Melting point:
153-155 C
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
Merck 
14,8265
CAS DataBase Reference
122320-73-4(CAS DataBase Reference)

SAFETY

Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  XJ5813850
Hazardous Substances Data 122320-73-4(Hazardous Substances Data)

Rosiglitazone price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R2408 Rosiglitazone ≥98% (HPLC) 122320-73-4 10mg $74.1 2018-11-13 Buy
Sigma-Aldrich R2408 Rosiglitazone ≥98% (HPLC) 122320-73-4 50mg $300 2018-11-13 Buy
TCI Chemical R0106 Rosiglitazone >98.0%(HPLC)(T) 122320-73-4 200mg $45 2018-11-22 Buy
TCI Chemical R0106 Rosiglitazone >98.0%(HPLC)(T) 122320-73-4 1g $159 2018-11-22 Buy
Cayman Chemical 71740 Rosiglitazone ≥98% 122320-73-4 10mg $28 2018-11-13 Buy

Rosiglitazone Chemical Properties,Uses,Production

Description

Rosiglitazone is a type of thiazolidinedione antidiabetics. Thiazolidinedione are agonists for peroxisome-proliferator–activated receptor γ (PPAR-γ). PPAR-γ receptors are ligand-activated nuclear transcription factors that modulate gene expression, lowering blood glucose primarily by increasing insulin sensitivity in peripheral tissues.
Rosiglitazone is widely used to lower blood glucose levels in patients with type 2 diabetes mellitus. Rosiglitazone functionalizes by makes the cells of the body more sensitive to the naturally produced insulin in body. It shouldn’t be used if the patient is injecting or inhaling insulin. Using rosiglitazone with insulin could increase the risk of heart failure. Patients having heart failure with symptoms or moderate to severe heart failure should not use Rosiglitazone.

References

[1] http://www.nejm.org/doi/full/10.1056/NEJMoa072761#t=article
[2] http://circ.ahajournals.org/content/128/8/785
[3] https://www.drugs.com/cdi/rosiglitazone.html

Uses

antidiabetic

Uses

A potent and selective PPARγ agonist.

Indications

Rosiglitazone is approved for use as monotherapy and in conjunction with metformin, though it is sometimes combined with a sulfonylurea or insulin. It is usually taken once or twice a day with or without food. Rosiglitazone may cause a modest increase in lowdensity lipoprotein and triglyceride concentrations, but it is unclear whether this effect has any clinical significance or persists in the long term.

brand name

Avandia (GlaxoSmithKline).

General Description

Rosiglitazone is 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, and is availableas the maleate salt in tablets containing the drug alone(Avandia) or in combination products with metformin(Avandamet) or with glimepiride (Avandaryl). The2-aminopyridine moiety allows for salt formation; the marketedformulations contain the 1:1 salt with maleic acid, inwhich the pyridine nitrogen accepts a proton, forming the2-aminopyridinium species.

General Description

Rosiglitazone, (±)-5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione(Avandia), is a white to off-white solid with pKavalues of 6.8 and 6.1. Rosiglitazone is readily soluble inethanol and a buffered aqueous solution with pH of 2.3; solubilitydecreases with increasing pH in the physiologicalrange. The molecule has a single chiral center and is presentas a racemate. Even so, the enantiomers are functionally indistinguishablebecause of rapid interconversion.

Clinical Use

Although rosiglitazone is extensively biotransformed—playing the major role in both transformations, and some involvementof CYP2C9.21,47 The sulfate conjugate M10 is thepredominant circulating metabolite by 4-hour postdose. Theextraordinarily high plasma protein binding of this metabolite(and the N-demethylated sulfate conjugate M4) in humans accountsfor the lengthy residence time of the radioactivity in thebody, despite the relatively short pharmacokinetic half-life(4–4.5 hours) of rosiglitazone itself.

Rosiglitazone Preparation Products And Raw materials

Raw materials

Preparation Products


Rosiglitazone Suppliers

Global( 238)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 305 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58
Shanghai JONLN Reagent Co., Ltd. 400-0066-400;021-60496031
021-55660885 shjlsw@163.com China 10256 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5984 61
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24560 81

View Lastest Price from Rosiglitazone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Rosiglitazone
122320-73-4
US $2.00 / kg 1kg 99% 100kg career henan chemical co

122320-73-4(Rosiglitazone)Related Search:


  • 5-(4-[2-(METHYL-PYRIDIN-2-YL-AMINO)-ETHOXY]-BENZYL)-THIAZOLIDINE-2,4-DIONE
  • 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]-phenyl]methyl]-2,4-thiazolidine-dione
  • AVANDIA
  • ROSIGLITAZONE
  • ROSIGLITAZONE HCL
  • Rosiglitazone free base
  • Rosiglitazone and its intermediates
  • ROSIGLITAZONE 99%
  • RosiglitazoneBase/Hcl/Maleate
  • 5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzylidine]-2,4-thiazolidinedione
  • 5-[[4-[2-(methyl-pyridin-2-yl-amino)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
  • BRL 49653
  • 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
  • 5-[4-[2-[methyl(2-pyridyl)amino]ethoxy]benzyl]thiazolidine-2,4-quinone
  • 2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-
  • (RS)-5-[4-(2-[Methyl(pyridin-2-yl)aMino]ethoxy)benzyl]thiazolidine-2,4-dione
  • 2-[(2-benzoylphenyl)aMino]-3-{4-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}propanoic acid
  • Rosiglitazone (Avandia)
  • Rosiglitazone(BRL 49653)
  • roiglitazone
  • 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-tiazolidinedione
  • Rosiglitazone 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]-phenyl]methyl]-2,4-thiazolidine-dione
  • Rosiglitazone, >=98.5%
  • 5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
  • ROEIGLITAZONEMALEATE
  • ROSIGLITAZONEHCL
  • ROSIGLIAZONE
  • ROSIGLIAZONE (5-{4-[2-(N-methyl-N-2-pyridyl)amino]-ethoxy}benzyl}-2,4-thiazolidinedione)
  • -
  • Inhibitor
  • AVANDIA
  • 122320-73-4
  • 15141-29-0
  • 122320-70-4
  • C18H19N3O3S
  • Active Pharmaceutical Ingredients
  • Rosiglitazone
  • API's
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