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Rosiglitazone

Description References
Rosiglitazone
Rosiglitazone structure
CAS No.
122320-73-4
Chemical Name:
Rosiglitazone
Synonyms
Rosig;RosigL;AVANDIA;itazone;BRL 49653;50MG/1G/1KG;ROSIGLIAZONE;roiglitazone;ROSIGLITAZONE;ROSIGLITAZONEHCL
CBNumber:
CB7133275
Molecular Formula:
C18H19N3O3S
Formula Weight:
357.43
MOL File:
122320-73-4.mol

Rosiglitazone Properties

Melting point:
153-155 C
Boiling point:
585.0±35.0 °C(Predicted)
Density 
1.315±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
pka
6.34±0.50(Predicted)
form 
powder
Merck 
14,8265
CAS DataBase Reference
122320-73-4(CAS DataBase Reference)
FDA UNII
05V02F2KDG
NCI Dictionary of Cancer Terms
Avandia
NCI Drug Dictionary
Avandia
IARC
3 (Vol. 108) 2016
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  XJ5813850
HS Code  2934100000

Rosiglitazone price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R2408 Rosiglitazone ≥98% (HPLC) 122320-73-4 10mg $79.8 2021-03-22 Buy
Sigma-Aldrich R2408 Rosiglitazone ≥98% (HPLC) 122320-73-4 50mg $324 2021-03-22 Buy
TCI Chemical R0106 Rosiglitazone >98.0%(HPLC)(T) 122320-73-4 200mg $48 2021-03-22 Buy
TCI Chemical R0106 Rosiglitazone >98.0%(HPLC)(T) 122320-73-4 1g $166 2021-03-22 Buy
Cayman Chemical 71740 Rosiglitazone ≥98% 122320-73-4 10mg $28 2021-03-22 Buy

Rosiglitazone Chemical Properties,Uses,Production

Description

Rosiglitazone is a type of thiazolidinedione antidiabetics. Thiazolidinedione are agonists for peroxisome-proliferator–activated receptor γ (PPAR-γ). PPAR-γ receptors are ligand-activated nuclear transcription factors that modulate gene expression, lowering blood glucose primarily by increasing insulin sensitivity in peripheral tissues.
Rosiglitazone is widely used to lower blood glucose levels in patients with type 2 diabetes mellitus. Rosiglitazone functionalizes by makes the cells of the body more sensitive to the naturally produced insulin in body. It shouldn’t be used if the patient is injecting or inhaling insulin. Using rosiglitazone with insulin could increase the risk of heart failure. Patients having heart failure with symptoms or moderate to severe heart failure should not use Rosiglitazone.

References

[1] http://www.nejm.org/doi/full/10.1056/NEJMoa072761#t=article
[2] http://circ.ahajournals.org/content/128/8/785
[3] https://www.drugs.com/cdi/rosiglitazone.html

Uses

antidiabetic

Uses

A potent and selective PPARγ agonist.

Indications

Rosiglitazone is approved for use as monotherapy and in conjunction with metformin, though it is sometimes combined with a sulfonylurea or insulin. It is usually taken once or twice a day with or without food. Rosiglitazone may cause a modest increase in lowdensity lipoprotein and triglyceride concentrations, but it is unclear whether this effect has any clinical significance or persists in the long term.

brand name

Avandia (GlaxoSmithKline).

General Description

Rosiglitazone is 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, and is availableas the maleate salt in tablets containing the drug alone(Avandia) or in combination products with metformin(Avandamet) or with glimepiride (Avandaryl). The2-aminopyridine moiety allows for salt formation; the marketedformulations contain the 1:1 salt with maleic acid, inwhich the pyridine nitrogen accepts a proton, forming the2-aminopyridinium species.

General Description

Rosiglitazone, (±)-5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione(Avandia), is a white to off-white solid with pKavalues of 6.8 and 6.1. Rosiglitazone is readily soluble inethanol and a buffered aqueous solution with pH of 2.3; solubilitydecreases with increasing pH in the physiologicalrange. The molecule has a single chiral center and is presentas a racemate. Even so, the enantiomers are functionally indistinguishablebecause of rapid interconversion.

Clinical Use

Although rosiglitazone is extensively biotransformed—playing the major role in both transformations, and some involvementof CYP2C9.21,47 The sulfate conjugate M10 is thepredominant circulating metabolite by 4-hour postdose. Theextraordinarily high plasma protein binding of this metabolite(and the N-demethylated sulfate conjugate M4) in humans accountsfor the lengthy residence time of the radioactivity in thebody, despite the relatively short pharmacokinetic half-life(4–4.5 hours) of rosiglitazone itself.

Rosiglitazone Preparation Products And Raw materials

Raw materials

Preparation Products


Rosiglitazone Suppliers

Global( 346)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5361 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58

View Lastest Price from Rosiglitazone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-18 Rosiglitazone
122320-73-4
US $90.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-07-13 Rosiglitazone
122320-73-4
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 Rosiglitazone
122320-73-4
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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