ChemicalBook >> CAS DataBase List >>7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- CAS No.
- 73942-87-7
- Chemical Name:
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Synonyms
- 8-Dimethoxy-1;Ivabradine Impurity 13;Ivabradine Impurity 73;Ivabradine Impurity 22;3-dihydro-2H-3-benzazepin-2-one;7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one;7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one;7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one>1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
- CBNumber:
- CB71503994
- Molecular Formula:
- C12H13NO3
- Molecular Weight:
- 219.24
- MDL Number:
- MFCD02091565
- MOL File:
- 73942-87-7.mol
Last updated:2023-12-18 16:59:08
| Melting point | 244.0 to 248.0 °C |
|---|---|
| Boiling point | 455.8±45.0 °C(Predicted) |
| Density | 1.167 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 13.29±0.20(Predicted) |
| color | Off-White to Pale Beige |
| LogP | 1.23 at 23℃ and pH6.47 |
| Surface tension | 71mN/m at 36.9mg/L and 19℃ |
| CAS DataBase Reference | 73942-87-7(CAS DataBase Reference) |
| FDA UNII | HV3ZHP3F8A |
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4824 | 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one >98.0%(GC) | 73942-87-7 | 1g | $72 | 2024-03-01 | Buy |
| TCI Chemical | D4824 | 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one >98.0%(GC) | 73942-87-7 | 5g | $285 | 2024-03-01 | Buy |
| TRC | D461010 | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one | 73942-87-7 | 1g | $80 | 2021-12-16 | Buy |
| AK Scientific | J97545 | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one | 73942-87-7 | 5g | $77 | 2021-12-16 | Buy |
| Chem-Impex | 43244 | 7,8-Dimethoxy-1H-benzo[δ]azepin-2(3H)-one,≥98%(GC) ≥98%(GC) | 73942-87-7 | 1G | $39.29 | 2021-12-16 | Buy |
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Uses,Production
Uses
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.
Application
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.
Definition
ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine.
Synthesis
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
Synthesis of 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one from N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 309)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd | +86-010-83386758 +86-18810831598 | jennifer@lianben.com | China | 85 | 58 |
| Jiangsu Yutian pharmaceutical Co.,Ltd. | +undefined-0518-86098006 +undefined19851887368 | lvan.hui@jsytsw.com | China | 80 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | alice@jndxj.com | China | 309 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-12-18 | 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one
73942-87-7
|
US $0.00-0.00 / KG | 1KG | 99% | 50000KG | Hebei Yibangte Import and Export Co. , Ltd. | |
 |
2023-11-01 | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
73942-87-7
|
US $0.00-0.00 / kg | 0.1kg | 99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |
 |
2023-10-21 | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
73942-87-7
|
US $50.00 / kg | 1kg | 0.99 | 10000 | Hebei Yanxi Chemical Co., Ltd. |
-
- 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one
73942-87-7
- US $0.00-0.00 / KG
- 99%
- Hebei Yibangte Import and Export Co. , Ltd.
-
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
73942-87-7
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
73942-87-7
- US $50.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
73942-87-7(7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one)Related Search:
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7
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