Z-Leu-Leu-Leu-B(OH)2 (MG262)
- CAS No.
- 179324-22-2
- Chemical Name:
- Z-Leu-Leu-Leu-B(OH)2 (MG262)
- Synonyms
- Z-Leu-Leu-Leu-B(OH)2 (MG262);Proteasome Inhibitor III - Calbiochem;L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-borono-3-methylbutyl]-;[(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acid
- CBNumber:
- CB71562203
- Molecular Formula:
- C25H42BN3O6
- Molecular Weight:
- 491.43
- MDL Number:
- MFCD02179373
- MOL File:
- 179324-22-2.mol
| Density | 1.101±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | -20C |
| solubility | ≥24.57 mg/mL in DMSO; insoluble in H2O; ≥96.4 mg/mL in EtOH |
| form | White solid |
| pka | 9.69±0.43(Predicted) |
| FDA UNII | 549V4DP94W |
Z-Leu-Leu-Leu-B(OH)2 (MG262) price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 539163-M | Proteasome Inhibitor III - Calbiochem The Proteasome Inhibitor III controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. | 179324-22-2 | 100μg | $364 | 2023-01-07 | Buy |
| Cayman Chemical | 10008311 | Z-Leu-Leu-Leu-B(OH)2 | 179324-22-2 | 200μg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 10008311 | Z-Leu-Leu-Leu-B(OH)2 | 179324-22-2 | 1mg | $1189 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | INB0000203 | MG-262 95.00% | 179324-22-2 | 5MG | $500.49 | 2021-12-16 | Buy |
| ApexBio Technology | A8179 | MG-262 | 179324-22-2 | 5mg | $700 | 2021-12-16 | Buy |
Z-Leu-Leu-Leu-B(OH)2 (MG262) Chemical Properties,Uses,Production
General Description
A boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 0.03 nM versus 4 nM for MG-132).
Biological Activity
mg-262 (also known as z-leu-leu-leu-b(oh)2), a boronic peptide acid, is a potent proteasome inhibitor that selectively and reversibly inhibits the chymotryptic activity of the proteasome. it consists of a peptide and boronic acid moiety which are functional to proteasome inhibition. according to previous studies, mg-262 is capable of reducing the viability of nasal mucosa and polyp fibroblasts, provoking cell growth arrest, inhibiting dna replication and retinoblastoma phosphorylation, increasing expression of the cell cycle inhibitor p21 and p27, and inducing cell death via loss of mitochondrial membrane potential, caspase-3 and poly(adp-ribose) polymerase activation, induction of c-jun phosphorylation and mitogen-activated protein kinase phosphatase-1 expression.laura pujols, laura fernandez-bertolin, mireya fuentes-prado, isam alobid, jordi roca-ferrer, neus agell, joaquim mullol, and cesar picado. proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts. the journal of pharmacology and experimental therapeutics 2012; 343:184-197hilary frase, jason hudak, and irene lee. identification of the proteasome inhibitor mg262 as a potent atp-dependent inhibitor of the salmonella enteric serovar typhimurium lon protease. biochemistry 2006; 45 (27): 8264-8274
Biochem/physiol Actions
Target Ki: 30 pM against proteasome
Z-Leu-Leu-Leu-B(OH)2 (MG262) Preparation Products And Raw materials
Raw materials
Preparation Products
Z-Leu-Leu-Leu-B(OH)2 (MG262) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 9625 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |