ANTI-INCENP
- CAS No.
- Chemical Name:
- ANTI-INCENP
- Synonyms
- ANTI-INCENP;ANTI-INNER CENTROMERE PROTEIN;Anti-INCENP antibody produced in rabbit
- CBNumber:
- CB7159703
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD05665235
- MOL File:
- Mol file
ANTI-INCENP price More Price(1)
ANTI-INCENP Chemical Properties,Uses,Production
Uses
Anti-INCENP antibody produced in rabbit has been used in western blotting and immunofluorescence.
General Description
The gene INCENP (inner centromere protein) encodes an inner centromere protein that forms a component of the chromosomal passenger complex (CPC). It is found to be localized to inner centromeres during mitosis. The CPC also contains Aurora B, survivin, and Borealin.
Biochem/physiol Actions
The inner centromere protein encoded by the INCENP gene is phosphorylated by Cdk1 (cyclin dependent kinase 1) in mitosis. It is found to be associated with Plk1 (Polo-like kinase) in a polo-box–dependent manner. Plk1 is a serine/threonine kinase that functions in cell cycle, especially in mitosis. INCEP participates in the localization of Bub1 (Budding uninhibited by benzimidazole 1), a serine/threonine kinase involved in spindle checkpoint, to kinetochore. This, in turn, promotes the recruitment of Plk1 to kinetochores. Phosphorylated INCENP stimulates the activity of Aurora B kinase at centromeres and the central spindle that is important for chromosome segregation and cytokinesis, respectively.
ANTI-INCENP Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-INCENP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |