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Inosine

Inosine
Inosine structure
CAS No.
58-63-9
Chemical Name:
Inosine
Synonyms
Ino;HXR;Atorel;Inosie;Selfer;C00294;nosine;INO 495;Oxiamin;INOSINE
CBNumber:
CB7161412
Molecular Formula:
C10H12N4O5
Formula Weight:
268.23
MOL File:
58-63-9.mol

Inosine Properties

Melting point:
222-226 °C (dec.) (lit.)
alpha 
-49.2 º (c=1,H2O 18 ºC)
Boiling point:
226 C (dec.)
Density 
1.3846 (rough estimate)
refractive index 
-52 ° (C=1, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: 0.5 M, clear, colorless
pka
13.24±0.70(Predicted)
form 
Crystalline Powder
color 
White
Odor
Odorless
Water Solubility 
2.1 g/100 mL (20 ºC)
Merck 
14,4975
BRN 
624889
Stability:
Hygroscopic
InChIKey
UGQMRVRMYYASKQ-PKJMTWSGSA-N
CAS DataBase Reference
58-63-9(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
5A614L51CT
NIST Chemistry Reference
Inosine(58-63-9)
EPA Substance Registry System
Inosine (58-63-9)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  2
RTECS  NM7460000
10
TSCA  Yes
HS Code  29389090
Toxicity LD50 oral in rat: > 10gm/kg

Inosine price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I4125 Inosine ≥99% (HPLC) 58-63-9 1g $44.4 2021-03-22 Buy
Sigma-Aldrich I4125 Inosine ≥99% (HPLC) 58-63-9 5g $57.6 2021-03-22 Buy
TCI Chemical I0037 Inosine >98.0%(HPLC)(T) 58-63-9 25g $57 2021-03-22 Buy
TCI Chemical I0037 Inosine >98.0%(HPLC)(T) 58-63-9 500g $496 2021-03-22 Buy
Alfa Aesar A14459 Inosine, 98+% 58-63-9 5g $23.9 2020-06-24 Buy

Inosine Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Originator

Foreart,Guarnieri,Italy,1970

Occurrence

Inosine is a synthetic

Uses

Has neuroprotective properties improving axonal wiring. Has been used to treat stroke patients to restore neural function.

Uses

cell function activator, cardiotonic

Definition

ChEBI: A purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N9-glycosidic bond.

Manufacturing Process

As described in US Patent 3,049,536, inosine may be prepared starting with adenosine.
The Deamination of Adenosine: 20 g of adenosine are dissolved in one liter of water by warming, and after cooling to room temperature 120 g of barium nitrite (monohydrate) are added to the solution. Under stirring there is added in time intervals of one hour 160 cc of 2 N sulfuric acid after each time interval. After the third addition, the reaction mass is allowed to stand for 3 hours at room temperature. The solution is then tested for barium, and if some barium is still present a slight excess of sulfuric acid is added. 300 cc of methanol is then added. In order to drive off the excess of nitrous acid, CO2 is conducted through the solution until the solution is free of nitrous acid as determined by testing with potassium iodide-starch paper. The precipitated barium sulfate is separated by centrifugation. The residue is washed one time with about 500 cc of water. The total volume of the centrifugate is about 2.3 liters.
Isolation of Inosine by Ion Exchange Method: Half of the above clear centrifugate (1.15 liters) is treated with 250 cc of anion exchange (bicarbonate form) and stirred together therewith for 16 hours at room temperature. The pH value is increased thereby to about 4 to 5. The ion exchanger is filtered off under suction and washed 3 times, each time with 150 cc of water. The solution is brought to a pH value of 7 by means of normal sodium hydroxide (total volume of the solution about 1.55 liters), and concentrated to a volume of about 100 cc under vacuum.
The inosine is crystallized overnight in an ice box and the inosine is then filtered off by suction, washed with a small amount of ice water and dried at a temperature of 105°C. A first fraction of crude inosine consisting of 5.4 g having a purity of 99% is obtained. Further fractions of crude inosine are obtained from the mother liquid by concentration, the total amount constituting 3.2 g having a purity of 96 to 98%. The yield of crude inosine is 8.6 g which is equal to 86%.
Recrystallization of the Crude Inosine: 17.0 g of crude inosine are dissolved in 400 cc of 80% ethanol in a water bath, filtered while hot and brought to crystallization in an ice box. After standing overnight the crystalline material is filtered off under suction and washed with ice water. The pure inosine is dried in a drying chamber at a temperature of 105°C. The yield of pure inosine is 15.0 g which is equal to 75%. The yield can be further increased by workingup the mother liquor of the crystallization as set forth above.
Alternatively, inosine may be made by fermentation as described in US Patent 3,111,459. 3 ml portions of a culture medium consisting of glucose (5 g/dl), ammonium chloride (0.4 g/dl), urea (0.4 g/dl), KH2PO4 (0.1 g/dl), MgSO4 · 7H2O (0.02 g/dl), Mn++ (2 ppm), Fe++ (2ppm), casein hydrolyzate (0.2 g/dl), yeast extract (0.2 g/dl), corn steep liquor (0.2 ml/dl), polypeptone (0.1 g/dl), meat extract (0.1 g/dl) and sodium ribonucleate (10 mg/dl) were poured into respective test tubes and each tube was sterilized at 115°C for 10 minutes. Thereafter separately sterilized calcium carbonate was added in the amount of 2 g/dl and then cells of Bacillus subtilis S26910 were inoculated into the above media and cultured with shaking at 30°C for 20 hours.
The resulting culture liquids were utilized for seeding, 20 ml of the medium having the composition described above were poured into a 500 ml shaking flask and sterilized at 115°C for 10 minutes and five drops of the above seed were added, and then cultured with shaking at 30°C for 65 hours. Thereafter 0.15 g/dl of inosine were accumulated.
The inosine-containing solution, which was obtained by separating the cells from the resulting fermentation liquid, was treated with both decolorizing resins and anion exchange resins by means of a conventional method and then acetone was added to crystallize the inosine. 1.47 g of the crude crystals of inosine were obtained from 3.5 liters of the culture liquid containing 1 g of inosine per liter.

Therapeutic Function

Cardiotonic

Purification Methods

(-)-Inosine forms anhydrous crystals from aqueous 80% EtOH but the dihydrate from H2O. [Beilstein 31 H 25, 26 III/IV 2087.]

Inosine Preparation Products And Raw materials

Raw materials

Preparation Products


Inosine Suppliers

Global( 505)Suppliers
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
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+86-371-66670886
info@dakenchem.com China 21075 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
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86-0551-65418684 info@tnjchem.com China 3001 55
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+8613734021967
kaia@neputrading.com CHINA 1010 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
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career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29968 58

View Lastest Price from Inosine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-18 Inosine
58-63-9
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-09-16 Inosine
58-63-9
US $0.00-0.00 / Kg/Drum 1KG 98%min; oral grade 500kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-14 Inosine
58-63-9
US $603.20-2063.50 / KG 1KG 99% 2000kg Baoji Guokang Healthchem co.,ltd

Inosine Spectrum


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