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Isobutyl chloroformate

CAS No.
543-27-1
Chemical Name:
Isobutyl chloroformate
Synonyms
IBCF;isobutyl carbonochloridate;ISOBUTYL CHLOROCARBONATE;2-Methylpropyl chloroformate;isobutyl chloformate;2-Methylpropyl carbonochloridate;2-methyl-1-propylchlorocarbonate;oroformate;Isobutyl chloroforma;Pramoxine Impurity 9
CBNumber:
CB7165612
Molecular Formula:
C5H9ClO2
Molecular Weight:
136.58
MDL Number:
MFCD00000642
MOL File:
543-27-1.mol
Last updated:2023-11-28 16:31:43

Isobutyl chloroformate Properties

Melting point -80°C
Boiling point 128.8 °C(lit.)
Density 1.053 g/mL at 25 °C(lit.)
vapor pressure 0.33 mm Hg ( 20 °C)
refractive index n20/D 1.407(lit.)
Flash point 82 °F
storage temp. 2-8°C
solubility benzene: miscible
form Liquid
color Clear
Water Solubility Immiscible with water.
Sensitive Moisture Sensitive
Merck 14,5139
BRN 956590
Dielectric constant 9.2(20℃)
Stability Moisture Sensitive
CAS DataBase Reference 543-27-1(CAS DataBase Reference)
FDA UNII 6S785TC0OB
NIST Chemistry Reference Isobutyl chloroformate(543-27-1)
EPA Substance Registry System Isobutyl chloroformate (543-27-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS06
Signal word  Danger
Hazard statements  H226-H302-H314-H331
Precautionary statements  P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  10-22-23-34
Safety Statements  26-36/37/39-45
RIDADR  UN 3390 6.1/PG 1
WGK Germany  2
10-19
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29159000
Toxicity LD50 orally in Rabbit: 1400 mg/kg
NFPA 704
2
4 1

Isobutyl chloroformate price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.02358 Isobutyl chloroformate for synthesis 543-27-1 100mL $47.8 2024-03-01 Buy
Sigma-Aldrich 8.02358 Isobutyl chloroformate for synthesis 543-27-1 2.5L $528 2024-03-01 Buy
Sigma-Aldrich 177989 Isobutyl chloroformate 98% 543-27-1 25g $41.3 2024-03-01 Buy
Sigma-Aldrich 177989 Isobutyl chloroformate 98% 543-27-1 100g $43.4 2024-03-01 Buy
Alfa Aesar A14692 Isobutyl chloroformate, 98% 543-27-1 25g $23.2 2024-03-01 Buy
Product number Packaging Price Buy
8.02358 100mL $47.8 Buy
8.02358 2.5L $528 Buy
177989 25g $41.3 Buy
177989 100g $43.4 Buy
A14692 25g $23.2 Buy

Isobutyl chloroformate Chemical Properties,Uses,Production

Chemical Properties

clear liquid

Chemical Properties

A combustible, colorless to light-colored liquid.

Uses

Isobutyl chloroformate is used as a peptide reagent. It is also used in the preparation of phenethyl-carbamic acid isobutyl ester by reaction with phenethylamine.

General Description

A colorless to light-colored liquid. Insoluble in water and denser than water. Very corrosive to skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Combustible.

Air & Water Reactions

Highly flammable. Insoluble in water. Reacts with moisture in the air to produce highly corrosive and toxic fumes of hydrogen chloride gas. Decomposes exothermically in water.

Reactivity Profile

Isobutyl chloroformate is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Hazard

Flammable. Corrosive.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Potential Exposure

This is a high volume chemical with production exceeding 1 million pounds annually in the U.S . No specific use found

Shipping

UN2742 Chloroformates, toxic, corrosive, flammable, n.o.s., Hazard class: 6.1; Labels: 6.1—Poison Inhalation Hazard, 8—Corrosive material; 3—Flammable liquid; Technical Name Required, Potential Inhalation Hazard (Special Provision 5). PG II. UN3390 Toxic by inhalation liquid, corrosive, n.o.s. with an LC50 # 1000 mL/m3 and saturated vapor concentration ≥ 10 LC50, Hazard Class: 6.1; Labels: 6.1—Poisonous materials, 8—Corrosive material, Technical Name Required, Inhalation Hazard Zone B

Purification Methods

It can be dried over CaCl2 and fractionated at atmospheric pressure while keeping moisture out. Its purity can be checked by conversion to the phenyl urethane derivative with PhNCO [Saunders et al. J Am Chem Soc 73 3796 1951.] IR: 1780cm-1 [Thompson & Jameson Spectrochim Acta 13 236 1959, R.se JustusLiebigs Ann Chem 205 227 1880]. [Beilstein 3 IV 26.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, ethers, amines. Forms explosive mixture with air above flash point (27C). Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Decomposes exothermically in water. Reacts with moisture in air to produce highly corrosive and toxic fumes of hydrogen chloride gas

Waste Disposal

Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment. For proper handling and disposal, always comply with federal, state, and local regulations.

Global( 284)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58
Xiamen AmoyChem Co., Ltd
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CONIER CHEM AND PHARMA LIMITED
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career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
SIMAGCHEM CORP
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View Lastest Price from Isobutyl chloroformate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Isobutyl chloroformate pictures 2020-01-09 Isobutyl chloroformate
543-27-1
US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co
2-methylpropylchloroformate Chlorocarbonic acid isobutyl ester chlorocarbonicacidisobutylester Formic acid, chloro-, isobutyl ester Isobutyl chloridocarbonate Isobutyl chloroformate, AcroSeal, 98% Isobutyl chloroforMate, 98%, AcroSeal ISOBUTYL CHLOROFORMATE FOR SYNTHESIS Isobuthyl chloroforMate Chlorine acid butyl ester Isobutyl chloocarbonate ISOBUTYL CHLOROFORMATE CHLOROFORMIC ACID ISOBUTYL ESTER carbonochloridic acid 2-methylpropyl ester #niso-Butyl chloroformate Isobutylchloroformate,~90% Isobutylchloroformate,98% Isobutyl chloroformate 98% Isobutylchloroformate99% Chloroformic acid 2-methylpropyl ester Isobutyl chloroforma isobutyl chlrorformate oroformate Isobutyl Chloroformate > Isobutyl chloroformate, 98%, AcroSeal&trade 2-Methylpropyl carbonochloridate 2-Methylpropyl chloroformate isobutyl carbonochloridate IBCF ISOBUTYL CHLOROCARBONATE isobutyl chloformate 2-methyl-1-propylchlorocarbonate Isobutyl chloroformate (IBCF) Pramoxine Impurity 9 543-27-1 534-27-1 ClCO2CH2CHCH32 ClCOOCH2CHCH32 HALOGEN Building Blocks Carbonyl Compounds Acid Halides Organic Building Blocks Acid Halides Building Blocks Carbonyl Compounds Chemical Synthesis Organic Building Blocks Acid Halides Carbonyl Compounds Organic Building Blocks Organics CHLOROFORMATES bc0001