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Isobutyl chloroformate

Isobutyl chloroformate
Isobutyl chloroformate structure
Chemical Name:
Isobutyl chloroformate
IBCF;isobutyl chloformate;Isobutyl chloroforma;ISOBUTYL CHLOROFORMATE;isobutyl chlrorformate;Isobuthyl chloroforMate;Isobutyl chloocarbonate;ISOBUTYL CHLOROCARBONATE;Isobutylchloroformate99%;Chlorine acid butyl ester
Molecular Formula:
Formula Weight:
MOL File:

Isobutyl chloroformate Properties

Melting point:
Boiling point:
128.8 °C(lit.)
1.053 g/mL at 25 °C(lit.)
vapor pressure 
0.33 mm Hg ( 20 °C)
refractive index 
n20/D 1.407(lit.)
Flash point:
82 °F
storage temp. 
benzene: miscible
Water Solubility 
Immiscible with water.
Moisture Sensitive
CAS DataBase Reference
543-27-1(CAS DataBase Reference)
NIST Chemistry Reference
Isobutyl chloroformate(543-27-1)
EPA Substance Registry System
Carbonochloridic acid, 2-methylpropyl ester(543-27-1)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  10-22-23-34
Safety Statements  26-36/37/39-45
RIDADR  UN 3390 6.1/PG 1
WGK Germany  2
HazardClass  6.1
PackingGroup  I
HS Code  29159000
Toxicity LD50 orally in Rabbit: 1400 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P320 Specific treatment is urgent (see … on this label).
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Isobutyl chloroformate price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 177989 Isobutyl chloroformate 98% 543-27-1 25g $19.5 2018-11-20 Buy
Sigma-Aldrich 177989 Isobutyl chloroformate 98% 543-27-1 100g $31.6 2018-11-20 Buy
Alfa Aesar A14692 Isobutyl chloroformate, 98% 543-27-1 100g $29.5 2018-11-13 Buy
Alfa Aesar A14692 Isobutyl chloroformate, 98% 543-27-1 25g $16.1 2018-11-13 Buy
Sigma-Aldrich 8.02358 Isobutyl chloroformate for synthesis. CAS 543-27-1, EC Number 208-840-1, chemical formula ClCOOCH CH(CH ) ., for synthesis 543-27-1 8023582500 $195 2018-11-23 Buy

Isobutyl chloroformate Chemical Properties,Uses,Production

Chemical Properties

clear liquid

Chemical Properties

A combustible, colorless to light-colored liquid.


Peptide reagent.

General Description

A colorless to light-colored liquid. Insoluble in water and denser than water. Very corrosive to skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Combustible.

Air & Water Reactions

Highly flammable. Insoluble in water. Reacts with moisture in the air to produce highly corrosive and toxic fumes of hydrogen chloride gas. Decomposes exothermically in water.

Reactivity Profile

Isobutyl chloroformate is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].


Flammable. Corrosive.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Potential Exposure

This is a high volume chemical with production exceeding 1 million pounds annually in the U.S . No specific use found

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Rinse out mouth and do not induce vomiting. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. Rest and medical observation is essential. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy


UN2742 Chloroformates, toxic, corrosive, flammable, n.o.s., Hazard class: 6.1; Labels: 6.1—Poison Inhalation Hazard, 8—Corrosive material; 3—Flammable liquid; Technical Name Required, Potential Inhalation Hazard (Special Provision 5). PG II. UN3390 Toxic by inhalation liquid, corrosive, n.o.s. with an LC50 # 1000 mL/m3 and saturated vapor concentration ≥ 10 LC50, Hazard Class: 6.1; Labels: 6.1—Poisonous materials, 8—Corrosive material, Technical Name Required, Inhalation Hazard Zone B

Purification Methods

It can be dried over CaCl2 and fractionated at atmospheric pressure while keeping moisture out. Its purity can be checked by conversion to the phenyl urethane derivative with PhNCO [Saunders et al. J Am Chem Soc 73 3796 1951.] IR: 1780cm-1 [Thompson & Jameson Spectrochim Acta 13 236 1959, JustusLiebigs Ann Chem 205 227 1880]. [Beilstein 3 IV 26.]


Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, ethers, amines. Forms explosive mixture with air above flash point (27C). Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). Decomposes exothermically in water. Reacts with moisture in air to produce highly corrosive and toxic fumes of hydrogen chloride gas

Waste Disposal

Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment. For proper handling and disposal, always comply with federal, state, and local regulations.

Isobutyl chloroformate Preparation Products And Raw materials

Raw materials

Preparation Products

Isobutyl chloroformate Suppliers

Global( 171)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
career henan chemical co
+86-371-86658258 CHINA 19923 58
Wuxi Zhongkun Biochemical Technology Co., Ltd. 051085629785,051085625359,QQ974229108,QQ1373125882
051085625359 China 19218 58
Creasyn Finechem(Tianjin) Co., Ltd. 86-22-83945878,83945171,83945172
4008266163-06019 China 835 68
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
PharmaBlock Sciences (Nanjing),Inc. 400 025 5188
86-025-86918232 China 6448 55
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40277 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30168 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 China 24560 81

View Lastest Price from Isobutyl chloroformate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Isobutyl chloroformate
US $1.00 / kg 1kg 99% Customized career henan chemical co

Isobutyl chloroformate Spectrum

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