Tiamulin
- CAS No.
- 55297-95-5
- Chemical Name:
- Tiamulin
- Synonyms
- TIAMILIN;tiamulina;TiaMulin fuMerate API;(3aS,4R,5S,6S,8R,9R,9aR,10R)-Decahydro-8-[[2-(diethylamino)ethyl]thio]acetyloxy-5-hydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1-one;C12065;sq14055;tiavetp;iamulin;TIAMULIN;Tiamutin
- CBNumber:
- CB7171536
- Molecular Formula:
- C28H47NO4S
- Molecular Weight:
- 493.74
- MDL Number:
- MFCD00864839
- MOL File:
- 55297-95-5.mol
| Melting point | 147.5°C |
|---|---|
| Boiling point | 563.0±50.0 °C(Predicted) |
| Density | 1.0160 (rough estimate) |
| refractive index | 1.6550 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| pka | 14.65±0.70(Predicted) |
| color | Colourless |
| FDA 21 CFR | 556.732; 558.612 |
| CAS DataBase Reference | 55297-95-5(CAS DataBase Reference) |
| FDA UNII | E38WZ4U54R |
| EPA Substance Registry System | Tiamulin (55297-95-5) |
Tiamulin price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 34044 | Tiamulin VETRANAL?, analytical standard | 55297-95-5 | 100MG | $274 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1667355 | Tiamulin United States Pharmacopeia (USP) Reference Standard | 55297-95-5 | 100mg | $436 | 2024-03-01 | Buy |
| TRC | T436595 | Tiamulin | 55297-95-5 | 100mg | $180 | 2021-12-16 | Buy |
| Usbiological | 286986 | 5-Hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate | 55297-95-5 | 10g | $333 | 2021-12-16 | Buy |
| AK Scientific | I023 | Tiamulin | 55297-95-5 | 100mg | $314 | 2021-12-16 | Buy |
Tiamulin Chemical Properties,Uses,Production
Uses
Tiamulin is a derivative of Pleuromutilin. Antibacterial.
Uses
Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Like pleuromutilin, it inhibits protein synthesis by binding to domain V of 23S rRNA.
Definition
ChEBI: A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) fo the treatment of swine dysentery caused by Serpulina hyodysenteriae.
General Description
Tiamulin has been developed by that company in collaboration with E.R. Squibb & Sons for use against animal infec tions. Tiamulin is used against dysentery and Mycoplasma infections in sheep, swine, cattle, and chickens.
Safety Profile
Poison by intramuscular and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of SOx and NOx. See also MERCAPTANS.
Synthesis
Tiamulin was synthesized by Sandoz Co. in 1973, starting from pleuromutilin produced by Pleurotus mutilus.
Veterinary Drugs and Treatments
Tiamulin is approved for use in swine to treat pneumonia caused by susceptible strains of Haemophilus pleuropneumoniae and swine dysentery caused by Treponema hyodysenteriae. As a feed additive, it is used to cause increased weight gain in swine.
Tiamulin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 893 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 906 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
View Lastest Price from Tiamulin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-25 | Tiamulin
55297-95-5
|
US $0.00 / kg | 1kg | 99% | 5000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2023-03-06 | Tiamulin hyclate
55297-95-5
|
US $10.00 / KG | 1KG | 99% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2022-03-11 | tiamulin
55297-95-5
|
US $100.00 / bag | 1bag | 99 | 500 | Shanxi Naipu Import and Export Co.,Ltd |
-
- Tiamulin
55297-95-5
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Tiamulin hyclate
55297-95-5
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- tiamulin
55297-95-5
- US $100.00 / bag
- 99
- Shanxi Naipu Import and Export Co.,Ltd
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