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5-Methyl-2-pyrazinecarboxylic acid

5-Methyl-2-pyrazinecarboxylic acid structure

CAS No.: 5521-55-1

Chemical Name:: 5-Methyl-2-pyrazinecarboxylic acid

Synonyms: 5-METHYLPYRAZINE-2-CARBOXYLIC ACID;2-Carboxy-5-methylpyrazine;5MPZA;TIMTEC-BB SBB006622;Glipizide Impurity 7;Glipizide Impurity 31;5-Methyl pyrazine-2-acid;5-Methyl-2-pyrazinoic Acid;3-Carboxy-5-methylpyrazine;2-METHYL-5-PYRAZINOIC ACID

CBNumber:: CB7173747

Molecular Formula:: C6H6N2O2

Molecular Weight:: 138.12

MDL Number:: MFCD00068241

MOL File:: 5521-55-1.mol

MSDS File:: SDS

Last updated:2025-07-24 18:12:21

Product description	Number	Pack Size	Price
5-Methyl-2-pyrazinecarboxylic acid 98%	347647	5g	$60.2
5-Methyl-2-pyrazinecarboxylic acid 98%	347647	25g	$183
5-Methylpyrazine-2-carboxylic Acid >98.0%(GC)(T)	M1003	5g	$18
5-Methylpyrazine-2-carboxylic Acid >98.0%(GC)(T)	M1003	25g	$69
5-Methylpyrazine-2-carboxylic Acid	M325941	1g	$45
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5-Methyl-2-pyrazinecarboxylic acid Properties

Melting point	167-171 °C(lit.)
Boiling point	253.51°C (rough estimate)
Density	1.3471 (rough estimate)
refractive index	1.5100 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	3.53±0.10(Predicted)
form	Amorphous Powder
color	Orange
BRN	116005
InChI	InChI=1S/C6H6N2O2/c1-4-2-8-5(3-7-4)6(9)10/h2-3H,1H3,(H,9,10)
InChIKey	RBYJWCRKFLGNDB-UHFFFAOYSA-N
SMILES	C1(C(O)=O)=NC=C(C)N=C1
LogP	-0.254 (est)
CAS DataBase Reference	5521-55-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	B861RS5NHI
NIST Chemistry Reference	2-Methylpyrazine-5-carboxylic acid(5521-55-1)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Risk Statements

41-36/37/38

Safety Statements

26-39-36

WGK Germany

Hazard Note

Irritant

HS Code

29339990

NFPA 704

	0
2		0

5-Methyl-2-pyrazinecarboxylic acid price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	347647	5-Methyl-2-pyrazinecarboxylic acid 98%	5521-55-1	5g	$60.2	2025-07-31	Buy
Sigma-Aldrich	347647	5-Methyl-2-pyrazinecarboxylic acid 98%	5521-55-1	25g	$183	2025-07-31	Buy
TCI Chemical	M1003	5-Methylpyrazine-2-carboxylic Acid >98.0%(GC)(T)	5521-55-1	5g	$18	2025-07-31	Buy
TCI Chemical	M1003	5-Methylpyrazine-2-carboxylic Acid >98.0%(GC)(T)	5521-55-1	25g	$69	2025-07-31	Buy
TRC	M325941	5-Methylpyrazine-2-carboxylic Acid	5521-55-1	1g	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
347647	5g	$60.2	Buy
347647	25g	$183	Buy
M1003	5g	$18	Buy
M1003	25g	$69	Buy
M325941	1g	$45	Buy

5-Methyl-2-pyrazinecarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

Pale Brown Powder

Uses

5-Methyl-2-pyrazinecarboxylic acid may be used in the preparation of novel europium(III) complexes, (5-methyl-2-pyrazinecarboxylato) (phenanthroline)europium(III). It may be used in the synthesis of Ln-metal organic frameworks (MOFs).

General Description

5-Methyl-2-pyrazinecarboxylic acid is a pyrazine derivative. Simultaneous membrane based solvent extraction (MBSE) and membrane based solvent stripping (MBSS) of 5-methyl-2-pyrazine carboxylic acid (MPCA) has been studied. Mechanism of pertraction of MPCA through layered bulk liquid membranes has been studied. MPCA reacts with Ln(NO₃)₃·6H₂O and K₄[W(CN)₈]·2H₂O to form unique three-dimensional network structure which contains open channels.

Synthesis

5-Methylpyrazine-2-carboxylic acid is an intermediate of the lipid-lowering drug amoximus. It can be prepared by electrolytic oxidation of 2,5-dimethyl or 2-methyl-5-(substituted) methylpyrazine.

References

[1] Angewandte Chemie, 1992, vol. 104, # 6, p. 748 - 749
[2] Patent: CN108017586, 2018, A. Location in patent: Paragraph 0016; 0022-0025
[3] Patent: CN103787990, 2016, B. Location in patent: Paragraph 0035; 0036
[4] Organic Preparations and Procedures International, 1991, vol. 23, # 2, p. 188 - 190
[5] Synthesis, 1990, # 3, p. 207 - 208

5-Methyl-2-pyrazinecarboxylic acid synthesis

Synthesis of 5-Methyl-2-pyrazinecarboxylic acid from Acipimox

5-Methyl-2-pyrazinecarboxylic acid Preparation Products And Raw materials

Raw materials

2-Methylpyrazine Pyrazinemethanol, 5-methyl-, acetate (ester) 3-HYDROXY-5-METHYLPYRAZINE-2-CARBOXYLIC ACID diethyl pyrazine-2,5-dicarboxylate Pyrazine-2,5-dicarboxylic acid

2-(chloromethyl)-5-methylpyrazine hydrochloride 5-Methyl-2,3-pyrazinedicarboxylic acid 2-(CHLOROMETHYL)-5-METHYLPYRAZINE 5-Methyl-2-pyrazinemethanol Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI)

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Preparation Products

Acipimox 2-Pyrazinecarboxylic acid 2-Bromo-5-methylpyrazine METHYL 5-METHYLPYRAZINE-2-CARBOXYLATE tert-Butyl [5-(hydroxymethyl)pyrazin-2-yl]carbamate

5-Methyl-2-pyrazinecarboxylic acid Suppliers

Global( 539)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8462	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8768	58
Anhuyan (Hainan) Biotechnology Co., LTD	+86-18163349544; +8618163349544	mollylucking@foxmail.com	China	3000	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +8615350851019	admin@86-ss.com	China	999	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21614	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58

Supplier	Advantage
Shanghai UCHEM Inc.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Anhuyan (Hainan) Biotechnology Co., LTD	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

Synthesis, Solubility, and Bioproduction of 5-Methyl-2-pyrazinecarboxylic Acid
5-Methyl-2-pyrazinecarboxylic acid is a critical pharmaceutical intermediate for synthesizing drugs like glipizide, acimox, an....
Jun 11，2025

View Lastest Price from 5-Methyl-2-pyrazinecarboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-01	5-Methyl-2-pyrazinecarboxylic acid 5521-55-1	US $0.00-0.00 / Kg/Drum	1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2025-12-01	5-Methyl-2-pyrazinecarboxylic acid 5521-55-1	US $19.00-217.00 / g	25g	0.99	100	Shanghai UCHEM Inc.
2025-11-30	5-Methyl-2-pyrazinecarboxylic acid 5521-55-1			0.99		RongNa Biotechnology Co.,Ltd

5-Methyl-2-pyrazinecarboxylic acid
5521-55-1
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

5-Methyl-2-pyrazinecarboxylic acid
5521-55-1
US $19.00-217.00 / g
0.99
Shanghai UCHEM Inc.

5-Methyl-2-pyrazinecarboxylic acid
5521-55-1
0.99
RongNa Biotechnology Co.,Ltd

5-Methyl-2-pyrazinecarboxylic acid Spectrum

5-Methyl-2-pyrazinecarboxylic acid(5521-55-1)MS 5-Methyl-2-pyrazinecarboxylic acid(5521-55-1)¹HNMR 5-Methyl-2-pyrazinecarboxylic acid(5521-55-1)¹³CNMR 5-Methyl-2-pyrazinecarboxylic acid(5521-55-1)IR1 5-Methyl-2-pyrazinecarboxylic acid(5521-55-1)IR2 5-Methyl-2-pyrazinecarboxylic acid(5521-55-1)Raman

5521-55-1(5-Methyl-2-pyrazinecarboxylic acid)Related Search:

Methyl acrylate Glipizide Ethyl 2-(Chlorosulfonyl)acetate Tetramethylpyrazine Kresoxim-methyl

Pyrazinamide 2-Methylpyrazine METHYL THIOPHENE-2-CARBOXYLATE Sulfachoropyrazine sodium Methylparaben

Bensulfuron methyl Thiophanate-methyl Methyl 5-Methyl-2,3-pyrazinedicarboxylic acid Parathion-methyl

Methyl bromide 2-Methyl-5-pyrazinecarboxylic acid methyl ester 2,5-PYRAZINEDICARBOXYLIC ACID DIHYDRATE

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5-Methylpyrazine-2-carboxylicacid(Acipimoxintermediate) 5-Methyl-2-pyrazinecarboxylic acid,99% 5--2- Methylpyrazine carboxylic acid 5-Methyl-2-pyrazinecarboxylic acid 98% Methyl-2-pyrazinecarboxylic 2-Methyl-5-Pyrazine-Carboxylic Acid (5MPC) 5-Methylparazine-2-carboxylic acid 5-Methyl-2-pyrazinecarboxylic acid, 99% 5GR 5-Methyl-2-pyrazinoic Acid 5-Methyl-pyrazinecarboxylic acid 5-Methyl pyrazine-2-acid 5-Methyl-2-pyrazinecarboxylic acid SynonyMs 5-Methylpyrazine-2-carboxylic acid 3-Carboxy-5-methylpyrazine 5-methyl-pyrazinecarboxylicaci 5MPZA 2-METHYL-5-PYRAZINE CARBOXYLIC ACID 2-METHYL-5-PYRAZINOIC ACID 2-METHYLPYRAZINE-5-CARBOXYLIC ACID 5-METHYL-2-PYRAZINECARBOXYLIC ACID TIMTEC-BB SBB006622 5 METHYL PYRAZINE-2-CARBOXILIC ACID 2-METHYLPYRAZINE-5-CARBOXYLIC ACID 98% 2-Methylpyrazine-5-carboxylicacid,98% 2-Pyrazinecarboxylic acid, 5-methyl- Acipimox Impurity(5-methyl-2-pyrazinecarboxylic acid) Acipimox Impurit Ⅰ:5-Methyl-2-pyrazinecarboxylic acid Glipizide Impurity 31 5-methyl-2-pyrazinecarboxylate 5-Methylpyrazine-2-carboxylicAcid> Glipizide Impurity 7 5-Methylpyrazine-2-carboxylicaci 5-Methyl-2-pyrazinecarboxylic acid ISO 9001：2015 REACH N-methyl pyrazine-2-carboxylic acid 2-Carboxy-5-methylpyrazine 5-METHYLPYRAZINE-2-CARBOXYLIC ACID Isoquinoline,1-(7-bromophenyl)- 5-Methyl-Pyrazin-2-Carboxylic acid 99% 5-Methyl-2-pyrazinecarboxylic acid 5521-55-1 CAS NO.5521-55-1 Pyrazinecarboxylic acid, 5-methyl- 5521-55-1 5525-55-1 5512-55-1 C6H6N202 CARBOXYLIC ACID Building Blocks Mono- & Polyalkylpyrazines Pyrazinecarboxylic Acid & Derivatives Pyrazines Heterocyclic Building Blocks Mono- & Polyalkylpyrazines Pyrazinecarboxylic Acid & Derivatives Building Blocks Heterocyclic Building Blocks Aromatics Bases & Related Reagents Nucleotides Carboxylic Acids Pyrazines, Pyrimidines & Pyridazines