ChemicalBook >> CAS DataBase List >>GSK-CXCR2
GSK-CXCR2
- CAS No.
- 211096-49-0
- Chemical Name:
- GSK-CXCR2
- Synonyms
- GSK-CXCR2;SB 265610;SB265610 >=98% (HPLC);N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea;Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-;1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea;CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
- CBNumber:
- CB71872298
- Molecular Formula:
- C14H9BrN6O
- Molecular Weight:
- 357.16
- MDL Number:
- MFCD09971124
- MOL File:
- 211096-49-0.mol
- MSDS File:
- SDS
Last updated:2023-09-04 16:42:00
| Boiling point | 527.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.77±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| pka | 6.13±0.40(Predicted) |
| form | powder |
| color | white to light brown |
| FDA UNII | 9P785F0579 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
GSK-CXCR2 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0421 | SB265610 ≥98% (HPLC) | 211096-49-0 | 5mg | $160 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0421 | SB265610 ≥98% (HPLC) | 211096-49-0 | 25mg | $642 | 2024-03-01 | Buy |
| Cayman Chemical | 17879 | SB 265610 ≥98% | 211096-49-0 | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 17879 | SB 265610 ≥98% | 211096-49-0 | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 17879 | SB 265610 ≥98% | 211096-49-0 | 10mg | $223 | 2024-03-01 | Buy |
GSK-CXCR2 Chemical Properties,Uses,Production
Uses
SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist.
Biological Activity
Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
Biochem/physiol Actions
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
storage
Store at RT
GSK-CXCR2 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-CXCR2 Suppliers
Global( 64)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19185 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |
GSK-CXCR2
N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
SB 265610
1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea
Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-
SB265610 >=98% (HPLC)
CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
211096-49-0
C14H9BrN6O