Trolox
- CAS No.
- 53188-07-1
- Chemical Name:
- Trolox
- Synonyms
- TROLOX;TROLOX;troloxc;TROLOX(R);trolox tm;TROLOXTM C;Trolox(R),97%;Trolox, 97% 1GR;Trolox, 97% 5GR;Trolox Standard
- CBNumber:
- CB7188583
- Molecular Formula:
- C14H18O4
- Molecular Weight:
- 250.29
- MDL Number:
- MFCD00006846
- MOL File:
- 53188-07-1.mol
- MSDS File:
- SDS
| Melting point | 187-189 °C (lit.) |
|---|---|
| Boiling point | 313.42°C (rough estimate) |
| Density | 1.0616 (rough estimate) |
| refractive index | 1.4970 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Also soluble in Water at alkalinepH. |
| form | Crystalline Powder |
| pka | 3.35±0.20(Predicted) |
| color | White to faintly beige |
| BRN | 1384051 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17) |
| InChIKey | GLEVLJDDWXEYCO-UHFFFAOYSA-N |
| SMILES | C1(C)(C(O)=O)OC2=C(C)C(C)=C(O)C(C)=C2CC1 |
| CAS DataBase Reference | 53188-07-1(CAS DataBase Reference) |
| FDA UNII | S18UL9710X |
| EPA Substance Registry System | 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid (53188-07-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DJ2273000 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Trolox price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 238813 | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97% | 53188-07-1 | 1g | $78.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 238813 | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97% | 53188-07-1 | 5g | $194 | 2024-03-01 | Buy |
| TCI Chemical | H0726 | 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid >98.0%(GC)(T) | 53188-07-1 | 1g | $67 | 2024-03-01 | Buy |
| TCI Chemical | H0726 | 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid >98.0%(GC)(T) | 53188-07-1 | 5g | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 10011659 | Trolox ≥98% | 53188-07-1 | 250mg | $32 | 2024-03-01 | Buy |
Trolox Chemical Properties,Uses,Production
Description
Trolox (53188-07-1) is a water soluble derivative of vitamin E. Displays antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.3
Chemical Properties
white to fainly beige crystalline powder
Uses
Trolox is a Vitamin E analog that also maintains the antioxidant capabilities which Vitamin E shows. Neuroprotective product.
Uses
An antioxidant derived from water-soluble vitamin E
Application
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. lt is commonly used as a standard or positive control in antioxidant assays. In addition, trolox is used to assessthe role of oxidative injury in processes like neuronal cell death and aging. It is effective as adjunctivetherapy in the treatment of certain cancers.
Definition
ChEBI: A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capa ity of complex mixtures.
General Description
(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) exhibits radical scavenging and antioxidant activities.
Mechanism of action
Trolox can protect against oxidative stress, genotoxicity and inflammation induced by CS through ROS scavenging mechanism, and serve as a potential antioxidant prevention strategy against oxidative injury of ATII cells in CS-related lung diseases.
storage
Store at +4°C
References
1) Massey et al. (1990), Free radical damage in neonatal rat cardiac myocyte cultures: effects of alpha-tocopherol, Trolox and phytol; Free Radic. Biol. Med., 8 449 2) Chen et al. (1998), Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells; Mol. Pharmacol., 53 638 3) Brookes et al. (1996), Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes; Arch. Biochem. Biophys., 333 482
Trolox Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23662 | 75 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
View Lastest Price from Trolox manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-26 | Trolox
53188-07-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
53188-07-1
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2021-07-02 | (+/-)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97%
53188-07-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Trolox
53188-07-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
53188-07-1
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- (+/-)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97%
53188-07-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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