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Hydrocortisone acetate

Adrenocorticotropic hormone drugs Indications Contraindications Adverse Reactions Precautions Chemical Property Uses Production methods
Hydrocortisone acetate
Hydrocortisone acetate structure
CAS No.
50-03-3
Chemical Name:
Hydrocortisone acetate
Synonyms
Hc45;Mysone;Cordes;Cortef;Cortes;nsc741;Efcolin;Epifoam;Lenirit;NSC 741
CBNumber:
CB7196805
Molecular Formula:
C23H32O6
Formula Weight:
404.5
MOL File:
50-03-3.mol

Hydrocortisone acetate Properties

Melting point:
223 °C (dec.)(lit.)
alpha 
D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)
Boiling point:
446.1°C (rough estimate)
Density 
d420 1.289
refractive index 
1.4593 (estimate)
Flash point:
223°C
storage temp. 
0-6°C
solubility 
Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride
Water Solubility 
Insoluble in water.
Decomposition 
223 ºC
Merck 
14,4787
BRN 
2066841
Stability:
Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-03-3(CAS DataBase Reference)
NIST Chemistry Reference
Hydrocortisone acetate(50-03-3)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T
Risk Statements  63-10-45
Safety Statements  36/37-45-53
WGK Germany  3
RTECS  GM8960000
HS Code  29372100
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Hydrocortisone acetate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar A18089 Hydrocortisone acetate, 97+% 50-03-3 1g $31.6 2018-11-13 Buy
Alfa Aesar A18089 Hydrocortisone acetate, 97+% 50-03-3 5g $105 2018-11-13 Buy

Hydrocortisone acetate Chemical Properties,Uses,Production

Adrenocorticotropic hormone drugs

Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216~222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α-hydroxy progesterone.
Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added.

Indications

For allergic, non-infectious skin diseases and a number of proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and itching psychosis.

Figure 1 the chemical structure formula of tetra-fluoroethane.

Contraindications

1. This medicine and matrix components allergy and allergic to other glucocorticoids are prohibited.
2. The primary bacterial, fungal and viral infectious skin diseases such as disabledare prohibited.
The above information is edited by the chemicalbook of KuiMing.

Adverse Reactions

Long-term using can cause local skin atrophy, telangiectasia, pigmentation, folliculitis, perioral dermatitis and secondary infection.

Precautions

1. Not long-term, large-scale use.
2. The coated parts such as a burning sensation, itching, swelling, etc., should stop the medication.

Chemical Property

White or almost white crystalline powder, odorless. Mp218-221.5 ℃; 25D + 166 ° (dioxane) Specific rotation [α]; ethanol maximum absorption at 240nm wavelength. Insoluble in water, slightly soluble in ethanol (1: 230) and chloroform (1: 150), insoluble in ether.

Uses

Corticosteroid drugs, have anti-inflammatory, anti-allergic, anti-toxins, anti-shock effect.

Production methods

Hydrocortisone and acetic anhydride in pyridine esterification.

Chemical Properties

white powder

Uses

Glucocorticoid

brand name

Cortef Acetate (Pharmacia & Upjohn); Cortifoam (Schwarz Pharma); Cortril (Pfizer); Dricort (Ingram); Hydrocortone (Merck).

Purification Methods

The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]

Hydrocortisone acetate Preparation Products And Raw materials

Raw materials

Preparation Products


Hydrocortisone acetate Suppliers

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View Lastest Price from Hydrocortisone acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Hydrocortisone acetate
50-03-3
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-12-16 Hydrocortisone acetate
50-03-3
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2018-07-20 Hydrocortisone acetate
50-03-3
US $10.00 / KG 10G 99% 500kg/month Hebei Chisure Biotechnology Co., Ltd.

Hydrocortisone acetate Spectrum


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