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VALINOMYCIN

VALINOMYCIN
VALINOMYCIN structure
CAS No.
2001-95-8
Chemical Name:
VALINOMYCIN
Synonyms
nsc122023;VALINOMYCIN;-valyl)[qr];valinomicin;nsc122023[qr];VALINOMYCIN 99%;valinomicin[qr];Valinomycin,90%;Valinomycin,96%;antibioticn-329b
CBNumber:
CB7199194
Molecular Formula:
C54H90N6O18
Formula Weight:
1111.32
MOL File:
2001-95-8.mol

VALINOMYCIN Properties

Melting point:
186-190 °C
alpha 
D20 +31.0° (c = 1.6 in benzene)
Boiling point:
821.74°C (rough estimate)
Density 
1.060
refractive index 
1.6400 (estimate)
Flash point:
87℃
storage temp. 
2-8°C
solubility 
DMSO: ≥10 mg/mL
form 
solid
color 
white
optical activity
[α]20/D +32±2°, c = 1.6% in benzene
Water Solubility 
Soluble in DMSO at 10mg/ml. Insoluble in water
Merck 
13,9976
BRN 
78657
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS06
Signal word  Danger
Hazard statements  H300-H310-H300+H310-H227-H302-H312
Precautionary statements  P264-P280-P301+P310-P302+P350-P310-P262-P280h-P301+P310a-P405-P210e-P301+P312a-P321-P403+P235-P501a
Hazard Codes  Xn,T,T+,Xi
Risk Statements  27/28-36/37/38-21/22
Safety Statements  36-45-36/37-28-37/39-26
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  YV9468000
10-18-21
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  I
HS Code  29419090

VALINOMYCIN price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 676377 Valinomycin A cyclododecadepsi-peptide ionophore antibiotic. 2001-95-8 25mg $96.8 2018-11-20 Buy
Sigma-Aldrich 60403 Potassium ionophore I Selectophore 2001-95-8 100mg $341 2018-11-20 Buy
Alfa Aesar J62312 Valinomycin, 90+% 2001-95-8 100mg $229 2018-11-13 Buy
Alfa Aesar J67410 Valinomycin, 10 mg/ml in DMSO sterile-filtered 2001-95-8 1ml $49 2018-11-20 Buy
Cayman Chemical 10009152 Valinomycin ≥95% 2001-95-8 5mg $19 2018-11-19 Buy

VALINOMYCIN Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

Insecticide, nematocide, Patterson, Wright, US 3520973 (1970 to Am. Cyanamid).

Uses

antibiotic; LD50 (rat, po) 4 mg/kg

Uses

K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and anta gonizes ET-induced vasoconstriction. Used as insecticide, nematocide.

Uses

Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.

Uses

Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.

Definition

ChEBI: A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in severa Streptomyces strains.

General Description

Shiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S.

Reactivity Profile

VALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

VALINOMYCIN is highly toxic orally.

Fire Hazard

When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides.

Biological Activity

Selective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro .

Purification Methods

Recrystallise valinomycin from dibutyl ether or Et2O. It is dimorphic: modification A crystallises from n-octane, and modification B crystallises from EtOH/H2O. It is soluble in pet ether, CHCl3, AcOH, BuOAc and Me2CO. [Smith et al. J Am Chem Soc 97 7242 1975, UV, IR and NMR see Brocknmann & Schmidt-Kastner Chem Ber 88 57 1955, Beilstein 27 I 9728. 17 IV 9728.]

VALINOMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products


VALINOMYCIN Suppliers

Global( 103)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8921 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771
sales@heowns.com China 13987 60
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4030 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15426 60
BEST-REAGENT 400-1166-196 18981987031
028-84555506 QQ:800101999 cdhxsj@163.com China 9900 57

View Lastest Price from VALINOMYCIN manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-09 Valinomycin
2001-95-8
US $1.00 / KG 1KG 99% 25kg career henan chemical co

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