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NORCODEINE

CAS No.
467-15-2
Chemical Name:
NORCODEINE
Synonyms
NORCODEINE;Norcodeinum;N-Norcodeine;17-Norcodeine;(-)-N-Norcodeine;N-Demethylcodeine;N-Desmethylcodeine;Codeinone Impurity 5;3-O-Methylnormorphine;N-Demethylated codeine
CBNumber:
CB7211845
Molecular Formula:
C17H19NO3
Molecular Weight:
285.34
MDL Number:
MFCD00069317
MOL File:
467-15-2.mol
Last updated:2023-06-08 09:02:54

NORCODEINE Properties

Melting point 1850C
Boiling point 467.7±45.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
Flash point 9℃
storage temp. -20°C
solubility DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml
form A crystalline solid
pka pKa 9.23± 0.01(H2O,t =25±0.1,I=0.15(KCl)Ar)(Approximate)
FDA UNII 32W9P3T4ML

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  7-16-36/37-45
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
NFPA 704
0
3 0

NORCODEINE Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

(-)-N-Norcodeine is a metabolite of Codeine. Morphine derivative.

Definition

ChEBI: A morphinane-like compound that is the N-demethylated derivative of codeine.

Purification Methods

It crystallises from acetone or ethyl acetate. [Speyer & Walther Chem Ber 63 822 1930.] The hydrochloride has m 309o(dec) when crystallised from H2O. [Beilstein 18 III/IV 8091.]

NORCODEINE Preparation Products And Raw materials

Raw materials

Preparation Products

NORCODEINE (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxymorphinan-6-ol 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-morphinan-6-alpha-o 7,8-Didehydro-4,5-alpha-epoxy-3-methoxymorphinan-6-alpha-ol 7,8-didehydro-4,5-epoxy-3-methoxy-,(5-alpha,6-alpha)-morphinan-6-o Morphinan-6alpha-ol, 7,8-didehydro-4,5alpha-epoxy-3-methoxy- Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-, (5alpha,6alpha)- N-Demethylated codeine N-Demethylcodeine N-Desmethylcodeine N-Norcodeine Normorphine 3-methyl ether (5a,6a)-7,8-Didehydro-4,5-epoxy-3-methoxy-morphinan-6-ol 17-Norcodeine 3-O-Methylnormorphine Norcodeinum NORCODEINE,1.0MG/MLINMETHANOL NORCODEINE TRIFLUOROACETATE 7,8-Didehydro-4,5α-epoxy-3-methoxymorphinan-6α-ol Norcodeine solution HKOIXWVRNLGFOR-KOFBORESSA-N Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-, (5α,6α)- (-)-N-Norcodeine 4,5α-epoxy-3-methoxy-7,8-didehydromorphinan-6α-ol(norcodeine) Codeinone Impurity 5 Codeine Monohydrate EP Impurity H Carfentrazone-ethyl Impurity 2 467-15-2 Chiral Reagents Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals