Monoethyl fumarate
- CAS No.
- 2459-05-4
- Chemical Name:
- Monoethyl fumarate
- Synonyms
- AKOS BBB/201;Ethylfumarat;ETHYL FUMARATE;Monoethyl FuMerate;MONOETHYL FUMARATE;monoethyl furmarate;ETHYL ACID FUMARATE;RARECHEM AL BE 1505;MonoethylFumarate>Mono-Ethyl fuMarate 95%
- CBNumber:
- CB7231119
- Molecular Formula:
- C6H8O4
- Molecular Weight:
- 144.13
- MDL Number:
- MFCD00002699
- MOL File:
- 2459-05-4.mol
- MSDS File:
- SDS
| Melting point | 66-68 °C (lit.) |
|---|---|
| Boiling point | 147 °C/16 mmHg (lit.) |
| Density | 1.1109 |
| refractive index | 1.4500 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 3.45±0.10(Predicted) |
| color | Almost white to beige |
| Water Solubility | Soluble in water. |
| BRN | 1723588 |
| Dielectric constant | 6.5（23.0℃） |
| CAS DataBase Reference | 2459-05-4(CAS DataBase Reference) |
| FDA UNII | Y3W849NG2N |
| NIST Chemistry Reference | Ethyl hydrogen fumarate(2459-05-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29171900 | |||||||||
| NFPA 704 |
|
Monoethyl fumarate price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 92585 | mono-Ethyl fumarate certified reference material, TraceCERT | 2459-05-4 | 50mg | $84.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 128422 | mono-Ethyl fumarate 95% | 2459-05-4 | 25g | $70.9 | 2024-03-01 | Buy |
| TCI Chemical | F0359 | Monoethyl Fumarate >97.0%(GC)(T) | 2459-05-4 | 25g | $97 | 2024-03-01 | Buy |
| TCI Chemical | F0359 | Monoethyl Fumarate >97.0%(GC)(T) | 2459-05-4 | 250g | $676 | 2024-03-01 | Buy |
| Usbiological | 012149 | Fumaric Acid Monoethyl Ester | 2459-05-4 | 1g | $319 | 2021-12-16 | Buy |
Monoethyl fumarate Chemical Properties,Uses,Production
Description
Monoethyl fumarate is the Monoethyl ester form of fumarate. It is a kind of effective preservative and polymerization agent for macromolecular material. Monoethyl fumarate is capable of inhibiting the growth of bacteria, yeast and mold and prolonging the storage time of feed can. It can also be used for long-term systemic therapy in the treatment of psoriasis (a chronic hyperproliferative inflammatory skin disorder). It is the most active ingredient in the antipsoriasis drug Fumadem. The mechanism is likely to be related to its effect of improvement of keratinocyte differentiation and inhibition of keratinocyte proliferation. Monomethyl fumarate has beneficial effects on the inflamed blood–brain barrier. It increases levels of endogenous antioxidant proteins in brain endothelial cells and reduces expression of VCAM-1 in inflamed brain endothelial cells. Transendothelial monocyte migration is limited upon MMF treatment.
References
Thio, H. B., et al. "Long‐term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm®;) in psoriasis." Journal of the European Academy of Dermatology & Venereology 4.1(1995):35-40.
Asadullah, K, et al. "Influence of monomethylfumarate on monocytic cytokine formation--explanation for adverse and therapeutic effects in psoriasis?." Archives of Dermatological Research 289.11(1997):623-30.
Lim, J. L., et al. "Protective effects of monomethyl fumarate at the inflamed blood-brain barrier." Microvascular Research 105(2016):61.
Zhao, Wen Xiu, C. M. Zhang, and X. U. Xue-Ming. "Synthesis and antimicrobial active of monomethyl fumarate." Science & Technology of Food Industry (2008).
Helwa, Inas. "The Mechanism of Monomethylfumarate (MMF) as an Anti-psoriatic Agent." Helwa Inas (2014)
Chemical Properties
ALMOST WHITE TO BEIGE CRYSTALLINE POWDER
Uses
Monoethyl fumarate is the monoethyl ester form of fumaric acid. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material.
Monoethyl fumarate (fumaric acid monoethyl ester, monoethyl fumarate) was used in the preparation of photo-crosslinkable macromers. It was also used to synthesize Ugi/intramolecular Diels-Alder (IMDA) cycloaddition products.
Definition
ChEBI: Monomethyl fumarate is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1. It has a role as an immunomodulator, an antioxidant and a drug metabolite. It is an enoate ester, a methyl ester and a dicarboxylic acid monoester. It derives from a fumaric acid.
Preparation
Monomethyl fumarate was synthesized by maleic anhydride and methanol. It is used to treat relapsing forms of multiple sclerosis in adults (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease).
Monoethyl fumarate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Monoethyl fumarate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-23 | Monoethyl fumarate
2459-05-4
|
US $20.00-10.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-10-09 | Monoethyl fumarate
2459-05-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | Monoethyl fumarate
2459-05-4
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Monoethyl fumarate
2459-05-4
- US $20.00-10.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Monoethyl fumarate
2459-05-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Monoethyl fumarate
2459-05-4
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.