Cyclobutanone
- CAS No.
- 1191-95-3
- Chemical Name:
- Cyclobutanone
- Synonyms
- CBON;obutanone;CYCLOBUTANONE;Oxocyclobutane;1-Oxocyclobutane;Cyclobutanone 98%;Cyclobutanone, 98+%;OS-7558Cyclobutanone;cyclobutanone(SALTDATA: FREE);Cyclobutanone, 98%, stabilized
- CBNumber:
- CB7231982
- Molecular Formula:
- C4H6O
Lewis structure
- Molecular Weight:
- 70.09
- MDL Number:
- MFCD00001332
- MOL File:
- 1191-95-3.mol
- MSDS File:
- SDS
| Melting point | -50.9 °C |
|---|---|
| Boiling point | 99 °C (lit.) |
| Density | 0.938 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 50 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Dichloromethane |
| form | Liquid |
| Specific Gravity | 0.938 |
| color | Clear colorless to slightly yellow |
| Water Solubility | INSOLUBLE |
| BRN | 1560289 |
| Stability | Volatile |
| InChIKey | SHQSVMDWKBRBGB-UHFFFAOYSA-N |
| CAS DataBase Reference | 1191-95-3(CAS DataBase Reference) |
| FDA UNII | 6PF2SH405U |
| EPA Substance Registry System | Cyclobutanone (1191-95-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243 | |||||||||
| Hazard Codes | F,F+ | |||||||||
| Risk Statements | 10-11 | |||||||||
| Safety Statements | 23-24/25-9-33-29-16-7/9 | |||||||||
| RIDADR | UN 1224 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29142900 | |||||||||
| NFPA 704 |
|
Cyclobutanone price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C96001 | Cyclobutanone 99% | 1191-95-3 | 1g | $33.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | C96001 | Cyclobutanone 99% | 1191-95-3 | 5g | $159 | 2024-03-01 | Buy |
| TCI Chemical | C1913 | Cyclobutanone (stabilized with Na2CO3) >97.0%(GC) | 1191-95-3 | 1g | $55 | 2024-03-01 | Buy |
| TCI Chemical | C1913 | Cyclobutanone (stabilized with Na2CO3) >97.0%(GC) | 1191-95-3 | 5g | $180 | 2024-03-01 | Buy |
| Alfa Aesar | A13068 | Cyclobutanone, 98%, stab. with ca 0.01% BHT | 1191-95-3 | 1g | $74.65 | 2024-03-01 | Buy |
Cyclobutanone Chemical Properties,Uses,Production
Description
Cyclobutanone is an organic compound with a four-membered cyclic ketone. It is used in preparation of cyclobutane derivatives, as a starting material for aminocyclobutanecarboxylic acid through sulfonyloxiranes, to prepare dihydro-furan-2-one in presence of polystyrene-bound phenylselenic acid as catalyst. It is also involved in the photochemical synthesis of nucleoside analogues such as bicyclic nucleosides and isonucleosides. Furthermore, it is used to synthesis fatty acid, 2-oxo-cyclobutane undecanoic acid, which is used in the development of an enzyme-linked immunosorbent assy for the detection of irradiated foods.
References
[1] https://en.wikipedia.org/wiki/Cyclobutanone
[2] https://www.alfa.com/de/catalog/A13068/
[3] https://www.scbt.com/scbt/de/product/2-oxo-cyclobutane-undecanoic-acid-169263-77-8/;jsessionid=Ay2KMCxORq9y-EC6YoYnGGtCnymUGxQi5Lpd-YuCZoW22Re8Xf4w!-2072765631
Chemical Properties
Clear colourless to slightly yellow liquid
Uses
Cyclobutanone is used in preparation of cyclobutane derivatives. It is used as a starting material for aminocyclobutanecarboxylic acid through sulfonyloxiranes. It is also used to prepare dihydro-furan-2-one in presence of polystyrene-bound phenylselenic acid as catalyst. Further, it is involved in the photochemical synthesis of nucleoside analogues such as bicyclic nucleosides and isonucleosides.
Preparation
The Russian chemist Nikolai Kischner first prepared cyclobutanone in 1905. He synthesized cyclobutanone in a low yield from cyclobutanecarboxylic acid in several reaction steps.
Another synthesis of cyclobutanone involves lithium-catalyzed rearrangement of oxaspiropentane, which is formed by epoxidation of the easily accessible methylenecyclopropane.
Purification Methods
Treat cyclobutanone with dilute aqueous KMnO4, dry it with molecular sieves and fractionally distil it. Purify it via the semicarbazone, then regenerate the ketone, dry it (CaSO4), and distil it in a stainless steel spinning-band (or Vigreux, p 11) column. Alternatively, purify it by preparative gas chromatography using a Carbowax 20-M column at 80o. (This treatment also removes acetone). The oxime has m 84-85o (from pet ether) and the semicarbazone has m 212-212-5o (220-221o from MeOH or H2O, Buchanan et al. J Am Chem Soc 64 2701 1942). [Salaun Org Synth 57 36 1977, Fitzer & Quabeck Synthesis 299 1987, Beilstein 7 IV 3.]
Cyclobutanone Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Karry Pharmachem Co., Ltd. | +8613567161161 | info@karrypharma.com | China | 34 | 58 |
| BTC Nantong Pharmaceuticals Technology Co.,Ltd | +8618068193575 | sales4@btcpharm.com | China | 254 | 58 |
| BTC pharm India | +918790379245 | banny.janga@btcpharm.com | India | 1269 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9344 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
View Lastest Price from Cyclobutanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-26 | Cyclobutanone
1191-95-3
|
US $0.00-0.00 / kg | 1kg | 98% | Kgs | BTC Nantong Pharmaceuticals Technology Co.,Ltd | |
 |
2023-11-01 | Cyclobutanone
1191-95-3
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |
 |
2023-05-12 | Cyclobutanone
1191-95-3
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD |
-
- Cyclobutanone
1191-95-3
- US $0.00-0.00 / kg
- 98%
- BTC Nantong Pharmaceuticals Technology Co.,Ltd
-
- Cyclobutanone
1191-95-3
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- Cyclobutanone
1191-95-3
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD