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Levomefolic Acid

Levomefolic Acid structure

CAS No.: 31690-09-2

Chemical Name:: Levomefolic Acid

Synonyms: 5-MTHF;L-5-Methyltetrahydrofolate;L-5-Methyltetrahydrofolic acid;(6S)-5-Methyltetrahydrofolic acid;N-[4-[[[(6S)-2-Amino-5-methyl-1,4,5,6,7,8-hexahydro-4-oxopteridine-6-yl]methyl]amino]benzoyl]-L-glutamic acid;l-N5;L-methyl acid;5lLCH3-folateH4;Unii-8S95dh25xc;Levomefolic acid

CBNumber:: CB72379121

Molecular Formula:: C20H25N7O6

Molecular Weight:: 459.46

MDL Number:: MFCD00870135

MOL File:: 31690-09-2.mol

Last updated:2023-12-09 09:37:17

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Levomefolic Acid Properties

Melting point	215-218oC
Density	1.62
storage temp.	Sealed in dry,Room Temperature
solubility	Aqueous Base (Slightly, Heated, Sonicated), DMSO (Slightly)
pka	3.51±0.10(Predicted)
form	Solid
color	Off-White to Light Green
FDA UNII	8S95DH25XC

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

Levomefolic Acid price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	L0335	Levomefolic Acid	31690-09-2	50MG	$214	2024-03-01	Buy
TCI Chemical	L0335	Levomefolic Acid	31690-09-2	250MG	$644	2024-03-01	Buy
Usbiological	015555	Levomefolic Acid	31690-09-2	5mg	$496	2021-12-16	Buy
Usbiological	281235	Levomefolic acid	31690-09-2	10g	$1238	2021-12-16	Buy
Usbiological	I0785-77	L-N5-	31690-09-2	1mg	$355	2021-12-16	Buy

Product number	Packaging	Price	Buy
L0335	50MG	$214	Buy
L0335	250MG	$644	Buy
015555	5mg	$496	Buy
281235	10g	$1238	Buy
I0785-77	1mg	$355	Buy

Levomefolic Acid Chemical Properties,Uses,Production

Description

Levomefolic Acid is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.

Mechanism

It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by methylenetetrahydrofolate reductase (MTHFR) from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).

Medical application

Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. IC50 value: Target: Folate analogLevomefolic acid has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. Levomefolic acid (5-MTHF) has the prominent antioxidant activity. A high dose of 5-MTHF or folic acid does not influence Natural killer (NK) cell function in vitro.
Preliminary research suggests that levomefolic acid (L-methylfolate) taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication,and might be a more cost-effective adjunctive agent than second-generation antipsychotics.

Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Uses

A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.

Uses

As a natural, active form of folic acid, Levomefolic Acid can be used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supple

Definition

ChEBI: 5-methyltetrahydrofolic acid is a tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5. It has a role as a human metabolite. It is functionally related to a 5,6,7,8-tetrahydrofolic acid. It is a conjugate acid of a 5-methyltetrahydrofolate(2-).

Levomefolic Acid synthesis

Synthesis of Levomefolic Acid from Folic acid

Levomefolic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

Levomefolic Acid Suppliers

Global( 173)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Jianfeng Chemical Co., Ltd	0531-88110457; +8615562555968	info@pharmachemm.com	China	246	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Jiangsu Yew Pharmaceutical Co., Ltd.	+86-510-66865338 +86-189-2133-5032 @	junwenjiang@live.cn	CHINA	30	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58

Supplier	Advantage
Jinan Jianfeng Chemical Co., Ltd	58
Hebei Guanlang Biotechnology Co,.LTD	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55
Jiangsu Yew Pharmaceutical Co., Ltd.	60
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hubei Ipure Biology Co., Ltd	58

View Lastest Price from Levomefolic Acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-18	Levomefolic Acid 31690-09-2	US $0.00-0.00 / kg	1kg	99%	3000kg	Jinan Jianfeng Chemical Co., Ltd
2024-04-12	L-5-Methyltetrahydrofolate 31690-09-2	US $0.00 / kg	1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2023-07-25	Levomefolic Acid 31690-09-2	US $5.00-2.00 / KG	1KG	99%	10000kg	Hebei Guanlang Biotechnology Co,.LTD

Levomefolic Acid
31690-09-2
US $0.00-0.00 / kg
99%
Jinan Jianfeng Chemical Co., Ltd

L-5-Methyltetrahydrofolate
31690-09-2
US $0.00 / kg
99%
Shaanxi Haibo Biotechnology Co., Ltd

Levomefolic Acid
31690-09-2
US $5.00-2.00 / KG
99%
Hebei Guanlang Biotechnology Co,.LTD

31690-09-2(Levomefolic Acid)Related Search:

(1R,4aS,4bR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,9,10,10a-octahydro phenanthrene-1-carboxylic acid Tetrahydrofurfuryl alcohol DIHYDROFOLIC ACID Glycine L-Tetrahydrofolic Acid

Folic acid

1of2

5lLCH3-folateH4 L(-)-5-Methyl-5,6,7,8-tetrahydrofolic acid lL-5-Methyltetrahydrofolic acid N-[4-[[[[(6S)-2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxopteridin]-6-yl]methyl]amino]benzoyl]-L-glutamic acid (S)-N-[4-[[(2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid Levomefolic acid 5-Methyl-(6S)-tetrahydrofolic Acid LevoMefolic Acid (See also L375720) l-N5 Methyl-L-tetrahydrofolic A N-[4-[[[(6S)-2-AMino-3,4,5,6,7,8-hexahydro-5-Methyl-4-oxo-6-pteridinyl]Methyl]aMino]benzoyl]-L-glutaMic Acid (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido) L-Glutamic acid, N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, (S)- Unii-8S95dh25xc (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzami 8-pentamethoxyflavone Levomefolic Acid D3Q: What is Levomefolic Acid D3 Q: What is the CAS Number of Levomefolic Acid D3 Q: What is the storage condition of Levomefolic Acid D3 Q: What are the applications of Levomefolic Acid D3 (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pen Levomefolic Acid USP/EP/BP (S)-2-[4-[[[(S)-2-Amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl]amino]benzamido]pentanedioic Acid N-[4-[[((6S)-2-Amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid L-Glutamic acid, N-[4-[[[(6S)-2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]- L-methyl acid Levomefolate (5-methyl-tetrahydrofolic acid) (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid L-5-Methyltetrahydrofola acide (6S)-5-Methyltetrahydrofolic acid N-[4-[[[(6S)-2-Amino-5-methyl-1,4,5,6,7,8-hexahydro-4-oxopteridine-6-yl]methyl]amino]benzoyl]-L-glutamic acid L-5-Methyltetrahydrofolate 5-MTHF L-5-Methyltetrahydrofolic acid (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioicaci L-Methyl Tetra Folate 31690-09-2 Amines Aromatics Drug Analogues Intermediates & Fine Chemicals Pharmaceuticals