N-(3-PYRIDYL)-INDOMETHACIN AMIDE
- CAS No.
- 261766-29-4
- Chemical Name:
- N-(3-PYRIDYL)-INDOMETHACIN AMIDE
- Synonyms
- N-3PYIA;Indomethacin N-Pyridyl Impurity;N-(3-PYRIDYL)-INDOMETHACIN AMIDE;N-(3-PYRIDYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(3-PYRIDYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-3-pyridinyl-1H-indole-3-acetaMide;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-pyridin-3-ylacetamide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-3-pyridinyl-;N-3PyIA, N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
- CBNumber:
- CB7244320
- Molecular Formula:
- C24H20ClN3O3
- Molecular Weight:
- 433.89
- MDL Number:
- MFCD02683393
- MOL File:
- Mol file
N-(3-PYRIDYL)-INDOMETHACIN AMIDE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0865 | N-(3-Pyridyl)indomethacinamide ≥98% | 261766-29-4 | 5MG | $280 | 2023-01-07 | Buy |
| Cayman Chemical | 70274 | N-(3-pyridyl)-Indomethacin amide ≥98% | 261766-29-4 | 1mg | $18 | 2024-03-01 | Buy |
| Cayman Chemical | 70274 | N-(3-pyridyl)-Indomethacin amide ≥98% | 261766-29-4 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 70274 | N-(3-pyridyl)-Indomethacin amide ≥98% | 261766-29-4 | 10mg | $129 | 2024-03-01 | Buy |
| Cayman Chemical | 70274 | N-(3-pyridyl)-Indomethacin amide ≥98% | 261766-29-4 | 50mg | $553 | 2024-03-01 | Buy |
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Chemical Properties,Uses,Production
Uses
An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant COX-2 with IC50 of 0.1 uM.
Biological Activity
n-(3-pyridyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(3-pyridyl)-indomethacin amide (n-3pyia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.052 and >66 μm, respectively. it is over 1300 times less potent as an inhibitor of ovine cox-1. n-(3-pyridyl)-indomethacin amide is the 3-pyridyl amide derivative of indomethacin that shows selective against cox-2 [1].
References
[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3-PYRIDYL)-INDOMETHACIN AMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 4257 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |