SC 57461A
- CAS No.
- 423169-68-0
- Chemical Name:
- SC 57461A
- Synonyms
- SC 57461;SC 57461A;SC-57461 Hydrochloride;N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alaninehydrochloride;3-((3-(4-Benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride;inhibit,SC57461A,SC 57461A,Leukotriene A4,SC-57461A,Inhibitor,Aminopeptidase,orally active,LTA4 hydrolase
- CBNumber:
- CB72446539
- Molecular Formula:
- C20H25NO3.ClH
- Molecular Weight:
- 363.882
- MDL Number:
- MFCD00951253
- MOL File:
- 423169-68-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319 | |||||||||
Precautionary statements | P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 26 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
SC 57461A price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PZ0110 | SC-57461A ≥98% (HPLC) | 423169-68-0 | 5mg | $147 | 2024-03-01 | Buy |
Sigma-Aldrich | PZ0110 | SC-57461A ≥98% (HPLC) | 423169-68-0 | 25mg | $461 | 2024-03-01 | Buy |
Cayman Chemical | 10108 | SC-57461A ≥98% | 423169-68-0 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 10108 | SC-57461A ≥98% | 423169-68-0 | 5mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 10108 | SC-57461A ≥98% | 423169-68-0 | 10mg | $169 | 2024-03-01 | Buy |
SC 57461A Chemical Properties,Uses,Production
Description
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto prostaglandin F1α production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.
Chemical Properties
White Solid
Uses
A potent and selective orally active leukotriene A4 hydrolase inhibitor.
Uses
SC 57461A is a potent and selective inhibitor of LTA4.
Biological Activity
Potent and selective inhibitor of LTA 4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC 4 synthase and 5-lipoxygenase. Potently inhibits LTB 4 production in whole blood (IC 50 = 49 nM). Orally active.
SC 57461A Preparation Products And Raw materials
Raw materials
Preparation Products
SC 57461A Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |