PIPERLONGUMINE
- CAS No.
- 20069-09-4
- Chemical Name:
- PIPERLONGUMINE
- Synonyms
- ong;PPLGM;umine;PiperL;ongumine;acryloyl);Piplartin;PIPLARTINE;PIPERLONGUMIN;Piperlorgumia
- CBNumber:
- CB7246450
- Molecular Formula:
- C17H19NO5
- Molecular Weight:
- 317.34
- MDL Number:
- MFCD00075706
- MOL File:
- 20069-09-4.mol
| Melting point | 124°C |
|---|---|
| Boiling point | 475.6±45.0 °C(Predicted) |
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL at warmed to 60°C |
| pka | -1.88±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| LogP | 2.340 (est) |
| FDA UNII | SGD66V4SVJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H320-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU7785850 | |||||||||
| HS Code | 2932209090 | |||||||||
| NFPA 704 |
|
PIPERLONGUMINE price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0221 | Piperlongumine ≥97% (HPLC) | 20069-09-4 | 5mg | $77.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 528124 | Piperlongumine | 20069-09-4 | 25mg | $85.2 | 2024-03-01 | Buy |
| TCI Chemical | P2361 | Piperlongumine >97.0%(HPLC) | 20069-09-4 | 25mg | $98 | 2024-03-01 | Buy |
| TCI Chemical | P2361 | Piperlongumine >97.0%(HPLC) | 20069-09-4 | 100mg | $313 | 2021-12-16 | Buy |
| Cayman Chemical | 11006 | Piperlongumine ≥98% | 20069-09-4 | 25mg | $44 | 2024-03-01 | Buy |
PIPERLONGUMINE Chemical Properties,Uses,Production
Description
A piperidinone alkaloid present in Piper longum, the structure has been shown to be N-(3:4:5-trimethoxycinnamoyl)-Lls-piperidin-2-one. In the plant, the base occurs mainly in the roots.
Uses
anti-asthma, antibronchitis
Uses
Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro.
Uses
Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed.
Definition
ChEBI: Piplartine is a member of cinnamamides and a dicarboximide.
General Description
Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache.
Biochem/physiol Actions
Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.
target
P450 (e.g. CYP17) | Antifection
References
Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)
PIPERLONGUMINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
View Lastest Price from PIPERLONGUMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-26 | PIPERLONGUMINE
20069-09-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2021-10-08 | Piplartine powder ;Piperlongumine
20069-09-4
|
US $0.00-0.00 / g | 1g | 98% | 100kgs | Wuhan Nutra Biotechnology Co.,Ltd | |
 |
2021-07-02 | Piperlongumine
20069-09-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- PIPERLONGUMINE
20069-09-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Piplartine powder ;Piperlongumine
20069-09-4
- US $0.00-0.00 / g
- 98%
- Wuhan Nutra Biotechnology Co.,Ltd
-
- Piperlongumine
20069-09-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd