Difluoromethyl phenyl sulfone
- CAS No.
- 1535-65-5
- Chemical Name:
- Difluoromethyl phenyl sulfone
- Synonyms
- PhSO2CF2H;[(Difluoromethyl)sulfonyl]benzene;Difluoromethyl phenyl sul;Phenyl difluoromethyl sulfone;Difluoromethyl phenyl sulfone;Difluoromethylphenylsulfone,95%;Difluoromethyl Phenyl Sulfone >1-(difluoroMethylsulfonyl)benzene;Difluoromethyl phenyl sulfone >=97%;Benzene, [(difluoroMethyl)sulfonyl]-
- CBNumber:
- CB72485024
- Molecular Formula:
- C7H6F2O2S
- Molecular Weight:
- 192.18
- MDL Number:
- MFCD01050170
- MOL File:
- 1535-65-5.mol
- MSDS File:
- SDS
| Melting point | 24-25℃ |
|---|---|
| Boiling point | 115-120 °C(Press: 7 Torr) |
| Density | 1.348 |
| refractive index | 1.5000 |
| Flash point | 128℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | liquid |
| color | colorless |
| Water Solubility | Soluble in chloroform and water. |
| BRN | 2259218 |
Difluoromethyl phenyl sulfone price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 742600 | Difluoromethyl phenyl sulfone ≥97% | 1535-65-5 | 1g | $82.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 742600 | Difluoromethyl phenyl sulfone ≥97% | 1535-65-5 | 10g | $478 | 2024-03-01 | Buy |
| TCI Chemical | D4764 | Difluoromethyl Phenyl Sulfone >98.0%(GC) | 1535-65-5 | 1g | $71 | 2024-03-01 | Buy |
| TCI Chemical | D4764 | Difluoromethyl Phenyl Sulfone >98.0%(GC) | 1535-65-5 | 5g | $248 | 2024-03-01 | Buy |
| Alfa Aesar | H64760 | Difluoromethyl phenyl sulfone, 95% | 1535-65-5 | 1g | $65.65 | 2024-03-01 | Buy |
Difluoromethyl phenyl sulfone Chemical Properties,Uses,Production
Description
Difluoromethyl phenyl sulfone is a powerful nucleophilic difluoromethylation reagent due to the high reactivity of the sulfonyl-stabilized difluoromethyl anion towards many electrophiles including carbonyls, imines, alkyl halides, and cyclic sulfates and sulfamidates. In the nucleophilic reaction step, depending on the substrate structure, strong bases are used to generate the nucleophilic (phenylsulfonyl)difluoromethyl anion in situ. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the (phenylsulfonyl)difluoromethylated compounds can undergo β-elimination to afford gem-difluoroalkenes.
Chemical Properties
light yellow liquid
Uses
Efficient reagent for difluoromethylation of carbonyls and aldehydes.
Uses
Difluoromethyl Phenyl Sulfone has been used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls
Reactions
(1) Difluoromethylation of alkyl halides.
(2) Difluoromethylation of aldehydes and ketones.
(3) Difluoromethylenation of aldimines and ketimines.
(4) Difluoromethylation of cyclic sulfates and sulfamidates.
(5) (Phenylsulfonyl)difluoromethylation of carboxylic acid esters.
(6) Difluoromethylenation of alkyl halides.
(7) Difluoromethylenation of aromatic aldehydes.
References
[1] G. PRAKASH. Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent.[J]. Organic Letters, 2004. DOI:10.1002/CHIN.200509059.
[2] G. K. SURYA PRAKASH. Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1-Difluoro-1-alkenes.[J]. ChemInform, 2005. DOI:10.1002/chin.200504098.
[3] G. K. SURYA PRAKASH. Nucleophilic Difluoromethylation of Primary Alkyl Halides Using Difluoromethyl Phenyl Sulfone as a Difluoromethyl Anion Equivalent[J]. Organic Letters, 2004, 6 23: 4315-4317. DOI:10.1021/ol048166i.
Difluoromethyl phenyl sulfone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
View Lastest Price from Difluoromethyl phenyl sulfone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-15 | Difluoromethyl phenyl sulfone
1535-65-5
|
US $0.10-0.10 / kg | 0.005kg | 99.99% | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2022-09-06 | Difluoromethyl phenyl sulfone
1535-65-5
|
US $0.00 / KG | 25KG | 97% | 1tone | Henan Aochuang Chemical Co.,Ltd. | |
![[(Difluoromethyl)sulfonyl]benzene pictures](https://img.chemicalbook.com/ProductImageEN/2018-12/Small/d5caddb7-6fef-4d11-a3e1-99dc236ef761.png) |
2019-07-06 | [(Difluoromethyl)sulfonyl]benzene
1535-65-5
|
US $1.00 / kg | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- Difluoromethyl phenyl sulfone
1535-65-5
- US $0.10-0.10 / kg
- 99.99%
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Difluoromethyl phenyl sulfone
1535-65-5
- US $0.00 / KG
- 97%
- Henan Aochuang Chemical Co.,Ltd.
-
- [(Difluoromethyl)sulfonyl]benzene
1535-65-5
- US $1.00 / kg
- 98%
- Career Henan Chemical Co