PD 153035 HYDROCHLORIDE
- CAS No.
- 153436-54-5
- Chemical Name:
- PD 153035 HYDROCHLORIDE
- Synonyms
- PD153035HCl;AG-1517 HCl;Zinc00600292;PD 153035(AG-1517);PD 153035 HYDROCHLORIDE;PD153035;ZM 252868; AG 1517;PD153035 (Tyrphostin AG 1517);PD153035;AG1517;PD-153035;AG-1517;4-Pyrimidinol,2-methoxy-10-methyl-;4-(3-Bromo-benzyl)-6,7-dimethoxy-quinazoline
- CBNumber:
- CB7249204
- Molecular Formula:
- C16H14BrN3O2
- Molecular Weight:
- 360.21
- MDL Number:
- MFCD00934896
- MOL File:
- 153436-54-5.mol
| Melting point | 189-190 °C |
|---|---|
| Boiling point | 472.1±45.0 °C(Predicted) |
| Density | 1.499±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| pka | 5.55±0.30(Predicted) |
| form | White to off-white solid. |
| color | White or off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| FDA UNII | TC62B68RSL |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
PD 153035 HYDROCHLORIDE price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18080 | PD 153035 ≥98% | 153436-54-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18080 | PD 153035 ≥98% | 153436-54-5 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 18080 | PD 153035 ≥98% | 153436-54-5 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 18080 | PD 153035 ≥98% | 153436-54-5 | 25mg | $381 | 2024-03-01 | Buy |
| Tocris | 1037 | PD153035 hydrochloride | 153436-54-5 | 10 | $154 | 2021-12-16 | Buy |
PD 153035 HYDROCHLORIDE Chemical Properties,Uses,Production
Description
AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.1?Inhibits the growth of a number of cancer cell lines.2?AG-1517 HCl is an extremely useful tool for exploring EGF-mediated cellular signaling.3
Chemical Properties
Yellowish solid
Uses
PD 153035 is an extremely potent and specific inhibitor of EGFR tyrosine kinase activity.
Uses
PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM).
Definition
ChEBI: A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.
Biological Activity
An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC 50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
target
EGFR
References
1) Fry et al. (1994), A specific inhibitor of the epidermal growth factor receptor tyrosine kinase; Science, 265 1093 2) Bos et al. (1997), PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner; Clin. Cancer Res., 3 2099 3) Tetreault et al. (2008), Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers; J. Cell. Biochem., 105 1240
PD 153035 HYDROCHLORIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from PD 153035 HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-06 | PD 153035 HYDROCHLORIDE
153436-54-5
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- PD 153035 HYDROCHLORIDE
153436-54-5
- US $1.00 / KG
- 98%
- Career Henan Chemical Co