Unii-0789652qul
- CAS No.
- 130112-42-4
- Chemical Name:
- Unii-0789652qul
- Synonyms
- Ccris 8109;Mivotilate;Unii-0789652qul;Mivotilate [inn];YH439 >=98% (HPLC);Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate;Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate;2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester;Propanoic acid, 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-, 1-methylethyl ester
- CBNumber:
- CB72496251
- Molecular Formula:
- C12H14N2O3S3
- Molecular Weight:
- 330.45
- MDL Number:
- MFCD02752797
- MOL File:
- 130112-42-4.mol
| Density | 1.467±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: ≥5mg/mL |
| form | solid |
| pka | 4.89±0.70(Predicted) |
| FDA UNII | 0789652QUL |
Unii-0789652qul price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y1646 | YH439 ≥98% (HPLC) | 130112-42-4 | 5mg | $165 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y1646 | YH439 ≥98% (HPLC) | 130112-42-4 | 25mg | $795 | 2023-01-07 | Buy |
| ChemScene | CS-0018393 | Mivotilate >98.0% | 130112-42-4 | 10mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-0018393 | Mivotilate >98.0% | 130112-42-4 | 5mg | $450 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0295004 | 2-(1,3-DITHIETAN-2-YLIDENE)-3-[(4-METHYL-2-THIAZOLYL)AMINO]-3-OXO-PROPANOIC ACID-1-METHYLETHYL ESTER 95.00% | 130112-42-4 | 5MG | $504.53 | 2021-12-16 | Buy |
Unii-0789652qul Chemical Properties,Uses,Production
Description
Mivotilate is an orally-active hepatoprotective agent introduced for the treatment of liver cirrhosis and hepatitis-B infection. It is a dithietanylidene malonate analogue of malotilate and is without the haemotological adverse effects associated with the latter. Mivotilate can be obtained by partial saponification of the corresponding diisopropylmalonate, conversion of the acid function into mixed anhydride then to the amide with an aminothiazole. It displays potent hepatoprotective activity in rat and mice liver injury models by a mechanism involving the inactivation of Kupffer cells. Mivotilate was shown to exert multiple effects on the hepatic cytochrome P450 system, particularly to inhibit CYP2E1 expression and to up-regulate the CYP1A1 expression. The low oral bioavailability of Mivotilate in rats (F<0.22%) could be primarilly attributed to poor absorption and considerable hepatic and gastrointestinal first-pass effects. Mivotilate prevents mutagenesis caused by agents such as benzo[a]pyrene and reduces skin tumors induced by these agents.
Originator
Yuhan Corp (South Korea)
Uses
Vasodilator (coronary).
Uses
Mivotilate, is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), that can be used as a hepatoprotective agent.
Definition
ChEBI: Mivotilate is an aromatic amide, an isopropyl ester and a secondary carboxamide.
Unii-0789652qul Preparation Products And Raw materials
Raw materials
Preparation Products
Unii-0789652qul Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |