Tak 799
- CAS No.
- 229005-80-5
- Chemical Name:
- Tak 799
- Synonyms
- CS-2889;Tak 799;Takeda 779;TAK-779(Cl);TAK 799 ;TAK 779;TAK-779 >=98% (HPLC);TAK-779;TAK 779;TAK779;TAK779;TAK 799;TAKEDA 779;TAK-779 Chemical Structure;N,N-Dimethyl-N-(4-(2-(p-tolyl)-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride
- CBNumber:
- CB72497117
- Molecular Formula:
- C33H39N2O2.Cl
- Molecular Weight:
- 531.136
- MDL Number:
- MFCD05662319
- MOL File:
- 229005-80-5.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble3mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| FDA UNII | BQW1Y9KIIP |
Tak 799 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0911 | TAK-779 ≥98% (HPLC) | 229005-80-5 | 5mg | $195 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0911 | TAK-779 ≥98% (HPLC) | 229005-80-5 | 25mg | $299.2 | 2024-03-01 | Buy |
| Cayman Chemical | 26744 | TAK-779 | 229005-80-5 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 26744 | TAK-779 | 229005-80-5 | 25mg | $344 | 2024-03-01 | Buy |
| Cayman Chemical | 26744 | TAK-779 | 229005-80-5 | 5mg | $129 | 2024-03-01 | Buy |
Tak 799 Chemical Properties,Uses,Production
Uses
TAK-779 has been used to inhibit CC chemokine ligand 5 (CCL5)– C-C chemokine receptor type 5 (CCR5) interaction in vitro in natural killer (NK) cytotoxicity assay. It has also been used as a blocker of CCR5 to study its effects and to evaluate the opening of the Panx-1 channels on peripheral blood mononuclear cells (PBMCs) isolated from human immunodeficiency virus (HIV)-infected individuals.
Biochem/physiol Actions
TAK-779 is a potent, dual antagonist at chemokine receptors C-C chemokine receptor type 2 (CCR2) and C-C chemokine receptor type 5 (CCR5) with IC50 = 1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and C-X-C motif chemokine receptor 4 (CXCR4).
storage
Store at -20°C
Tak 799 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 878 | 58 |