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Thiophanate-methyl

Description References
Thiophanate-methyl
Thiophanate-methyl structure
CAS No.
23564-05-8
Chemical Name:
Thiophanate-methyl
Synonyms
DO;nf44;ROKO;COVER;ditek;f6385;SIGMA;3336G;easout;pei190
CBNumber:
CB7249734
Molecular Formula:
C12H14N4O4S2
Formula Weight:
342.39
MOL File:
23564-05-8.mol

Thiophanate-methyl Properties

Melting point:
172°C
Density 
1.4542 (rough estimate)
vapor pressure 
<1.3 x 10-5 Pa (25 °C)
refractive index 
1.6000 (estimate)
storage temp. 
0-6°C
pka
7.28
form 
neat
Water Solubility 
<0.1 g/100 mL at 20 ºC
Merck 
13,9427
BRN 
937942
Stability:
Stable. Incompatible with strong oxidizing agents, alkalies, copper salts.
EWG's Food Scores
4-5
FDA UNII
K4N81R84L8
Proposition 65 List
Thiophanate Methyl
EPA Substance Registry System
Thiophanate-methyl (23564-05-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H317-H332-H341-H410
Precautionary statements  P261-P280
Hazard Codes  Xn;N,N,Xn
Risk Statements  20-43-50/53-68
Safety Statements  36/37-46-60-61
RIDADR  UN 3077
WGK Germany  2
RTECS  BA3675000
HS Code  29309090
Toxicity LD50 in rats, mice, guinea pigs, rabbits (g/kg): 3.40, 6.64, 3.64, 2.27 orally (Hashimoto)

Thiophanate-methyl price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 45688 Thiophanate-methyl PESTANAL 23564-05-8 250mg $33.2 2019-12-02 Buy

Thiophanate-methyl Chemical Properties,Uses,Production

Description

Thiophanate methyl is a member of benzimidazole and a systemic fungicide with protective and curative activity against a broad spectrum of fungal diseases including leaf spots, blotches, blights, fruit spots, rots, sooty mould, scabs, bulb/corn/tuber decays, blossom blights, powdery mildews, certain rusts, and common soil borne crown and root rots. It is used on a variety of tree, vine, root crops, canola, and wheat, as well as on lawns and ornamentals. Thiophanate methyl is absorbed by the roots and leaves. Thiophanate-methyl has a low mammalian toxicity. But, it is an irritant and a skin sensitizer. It may also be mutagen. Moderate toxicity of thiophanate methyl is observed for aquatic organisms and earthworms. In EU, thiophanate methyl is approved to control fungal diseases on crops, while in Australia it is not registered for use on food-producing species, while it is only for the control of soil-borne diseases of ornamentals plants. For application, Thiophanate-methyl is formulated into wettable powders containing 50 and 70% active ingredient.

References

  1. https://apvma.gov.au
  2. https://www.epa.gov
  3. https://sitem.herts.ac.uk
  4. http://www.inchem.org
  5. Terry R Roberts, David H Hutson, Philip W Lee, Peter H Nicholls, and Jack R Plimmer, Metabolic Pathways of Agrochemicals: Part 2: Insecticides and Fungicides, 1999, ISBN 978-0-85404-499-3

Chemical Properties

Methyl thiophanate is a colorless crystals, prisms or light brown powder.

Chemical Properties

colourless crystals, or white or light brown powder

Uses

Thiophanate-Methyl is a systematic fungicide of the thiophanate class. Thiophanate-Methyl is commonly used in agriculture to protect against powdery mildew, rot and other fungal diseases in fruits, ve getables and other crops.

Uses

Systemic fungicide.

Uses

Thiophanate methyl is a fungicide/wound protectant used to control plant diseases in stone fruit, pome fruit, tropical and subtropical fruit crops, grapes and fruiting vegetables. Thiophanate methyl is effective against a wide variety of fungal diseases such as leaf spots, blotches and blights; fruit spots and rots; sooty mould; scabs; bulb, corn and tuber decays; blossom blights; powdery mildews; certain rusts; and common soil borne crown and root rots.

Definition

ChEBI: A member of the class of thioureas that is the dimethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew a d grey mould.

General Description

Colorless crystals or light brown powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Thiophanate-methyl is incompatible with strong acids and bases, and with strong reducing agents such as hydrides. Produces flammable gaseous hydrogen with active metals or nitrides. Incompatible with strong oxidizing acids, peroxides. Incompatible with alkaline material. Forms complexes with copper salts .

Fire Hazard

Flash point data for Thiophanate-methyl are not available. Thiophanate-methyl is probably combustible.

Agricultural Uses

Fungicide: Thiophanate-methyl is a systemic fungicide used to control a broad spectrum of fungal diseases on fruits, vegetables, turf and ornamentals, including shade trees, and diseases in the field, nurseries, and in greenhouses. Note: Do not confuse with thiophanate-ethyl (CAS: 23564-06-9), which is not currently registered for use in the U.S. Registered for use in EU countries. Registered for use in the U.S.

Trade name

BASF® 32500 F; BASF® 32500 Fungicide; CERCOBIN®; CLEARY® 3336; CONSYST®; DITEK®[C]; DOMAIN®; DOUSAN®[C]; ENOVIT®; EVOLVE®; FANATE®; FUNGITOX®; FUNGO®; MILDOTHANE® Turf Liquid; NEOTOPSIN®; NF- 35®; NF-44®; NSC 170810®; PELT®; PRO-TURF®; SIPCAVIT®; SNARE®; SPECTRO®; SYSTEC®; SYSTEMIC® FUNGICIDE; TD 1771®; TOPSIN®; TOPSIN-WP METHYL®; 3336 TURF FUNGICIDE®; ZYBAN®

Potential Exposure

Methyl thiophanate is thiocarbamate ester, used in the synthesis of polymers and in agriculture as pesticides, soil fumigants, and seed disinfectants.

Carcinogenicity

Those long-term studies evaluated a variety of toxicity end points including carcinogenicity. Both benomyl and carbendazim were weak carcinogens in some in vivo studies. Rats of the SpDxAug strain were fed 80, 400, and 2000 ppm for 2 years and no evidence for an increase in tumors was seen. In carcinogenicity studies in mice with carbendazim, similar liver tumor finding were found in CD-1 or Swiss strains. On the other hand, no evidence of tumors was seen in a similar study conducted using the NMRKf mouse strain, a strain that has a low incidence of spontaneous tumors.

Metabolic pathway

Thiophanate methyl degradation in water (hydrolytic/ photolysis), soils, plants and animals follows a common pathway that involves the initial conversion into methyl benzimidazol-2-ylcarbamate (carbendazim). Prior to benzimidazole ring formation, at least one side chain undergoes an oxidative desulfuration reaction and partial hydrolysis (even to the substituted aniline). Once formed, carbendazim is degraded primarily via an oxidative mechanism (in animals) or through hydrolysis to 2-aminobenzimidazole (in soils). Possible metabolism pathways of thiophanate methyl are depicted in Scheme 1.

Shipping

UN2771 Thiocarbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Degradation

Thiophanate methyl (1) is susceptible to alkaline hydrolysis. The principal degradation product is carbendazim (2). Thiophanate methyl degraded slowly in water (pH 7-7.4, Noguchi et al., 1971), and in fruit juice (grape homogenate, Shiga et al., 1985) to primarily carbendazim, but also to 1-(3- methoxycarbony1thioureido)-2-(3-methoxycarbony1ureido)benzene (3) and dimethyl 4,4'-(o-phenylene)bis(allophanate) (4). Thiophanate methyl underwent photolysis in aqueous solution to carbendazim (DT50 <1 day) when illuminated with UV light (254 nm) or natural sunlight. A similar photolytic transformation occurred on moist cotton foliage, although no photolysis occurred when thiophanate methyl was exposed as a dry film to light (Buchenauer et al., 1973). Thiophanate methyl on wet filter paper decomposed in sunlight to yield carbendazim and small amounts of compounds 3 and 4 (Ono and Tohyama, 1982).

Incompatibilities

Thiocarbamate esters are combustible; dust may form explosive mixture with air. Decomposes163℃Thiocarbamate esters are combustible. They react violently with powerful oxidizers such as calcium hypochlorite. Poisonous gases are generated by the thermal decomposition of thiocarbamate compounds, including carbon disulfide, oxides of sulfur, oxides of nitrogen, hydrogen sulfide, ammonia, and methylamine. Thio and dithio carbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Flammable gases are generated by the combination of thiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates are incompatible with acids, peroxides, and acid halides.

Waste Disposal

In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Thiophanate-methyl Preparation Products And Raw materials

Raw materials

Preparation Products


Thiophanate-methyl Suppliers

Global( 179)Suppliers
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Hefei TNJ Chemical Industry Co.,Ltd.
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career henan chemical co
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Hubei Jusheng Technology Co.,Ltd.
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Shandong chuangyingchemical Co., Ltd.
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HENAN BON INDUSTRIAL CO.,LTD
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CONIER CHEM AND PHARMA LIMITED
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Shaanxi Dideu Medichem Co. Ltd
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Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
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View Lastest Price from Thiophanate-methyl manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-26 Thiophanate-methyl
23564-05-8
US $0.00-0.00 / 公斤 1公斤 99.0% 500 tons Shaanxi Dideu Medichem Co. Ltd
2019-03-08 Thiophanate-Methyl
23564-05-8
US $0.00 / kg 25kg 95%TC/70%WP/50%WP 1000MT Hefei TNJ Chemical Industry Co.,Ltd.
2018-12-20 Thiophanate-methyl
23564-05-8
US $1.00 / kg 1kg 99% Customized career henan chemical co

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