DL-METHIONINE METHYLSULFONIUM CHLORIDE
- CAS No.
- 1115-84-0
- Chemical Name:
- DL-METHIONINE METHYLSULFONIUM CHLORIDE
- Synonyms
- MMSC;u-vit;yucron;C04078;cabagin;ardesyl;Vitas U;merastom;epadyn-u;cabaginu
- CBNumber:
- CB7249996
- Molecular Formula:
- C6H14ClNO2S
- Molecular Weight:
- 199.7
- MDL Number:
- MFCD00067196
- MOL File:
- 1115-84-0.mol
- MSDS File:
- SDS
| Melting point | 134 °C (decomp) |
|---|---|
| FEMA | 3445 | DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE |
| storage temp. | Hygroscopic, Refrigerator, Under inert atmosphere |
| solubility | Water (Soluble), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Odor | at 100.00 %. malty tomato potato sulfury green |
| Odor Type | malty |
| JECFA Number | 1427 |
| Stability | Hygroscopic |
| LogP | 0.28 |
| CAS DataBase Reference | 1115-84-0(CAS DataBase Reference) |
| FDA UNII | G9CUR2204U |
| ATC code | A02BX04 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Toxicity | LD50 oral in rat: > 6gm/kg |
DL-METHIONINE METHYLSULFONIUM CHLORIDE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M260470 | L-Methionine-S-methylSulfoniumChloride | 1115-84-0 | 500mg | $135 | 2021-12-16 | Buy |
| Usbiological | 282085 | L-Methionine-S-methyl sulfonium chloride | 1115-84-0 | 500mg | $468 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 52118 | L-Methionine-S-methylSulfoniumChloride | 1115-84-0 | 1g | $650 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | VIT0000805 | METHYLMETHIONINE SULFONIUM CHLORIDE 95.00% | 1115-84-0 | 1G | $329.7 | 2021-12-16 | Buy |
DL-METHIONINE METHYLSULFONIUM CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Naturally occurs as the L-form in a variety of vegetables. Although used in food as a flavoring ingredient in fish products, it has also been used therapeutically in the treatment of peptic ulcers, colitis and gastritis.
Originator
Cabagin-U,Kowa
Occurrence
Reported found in asparagus, cabbage, cabbage juice, celery, sweet corn, milk, potato, tea, green tea and tomato.
Uses
A derivative of L-Methionine (M260440). Naturally occurring sulfonium compound found in a large number of plants. Identification of antiulcer vitamin in cabbage leaves. Antiulcerative.
Definition
ChEBI: Methylmethionine sulfonium salt is an organic molecular entity.
Application
Methiosulfonium chloride is used for its protective effect on the liver and gastrointestinal mucosa, whereas the iodide finds use for rheumatic disorders.
Manufacturing Process
298 g dl-methionine, 2000 ml water and 151.1 methyl chloride were put into autoclave (volume 3 L) made from V4-a steel. The mixture was heated at temperature 50°-55°C for 8 hours and pressure 12-13 atmospheres.
On cooling an excess of methyl chloride was evaporated, the slightly yellow residue was mixed with 0.2% activated coal and filtered. Water was evaporated in vacuum at 45°-55°C. 2 L methanol was poured into an almost colorless syrup obtained, cooled to -5°-(-10°)C. The methylmethioninesulfonium chloride crystallized.
It was filtered off to give 340 g (85.3%) of desired product 99.5 % purity (data of thin-layer chromatography).
Therapeutic Function
Hepatoprotectant
Taste threshold values
Taste characteristics at 5 ppm: sulfureous creamy, tomato, malty, vegetable like
Trade name
Chloride: Ardesyl (Beytout, France), withdrawn from the market; Cabagin (Kowa, Japan). Iodide: Lobarthrose (Opodex, France), withdrawn from the market.
Purification Methods
Likely impurities are methionine, methionine sulfoxide and methionine sulfone. Crystallise Vitamin U from water by adding a large excess of EtOH. It is hygroscopic. It should be stored in a cool, dry place and protected from light. It has also been purified on a column of Dowex 50 H+ form, washed with H2O and eluted with 6N ammonia, lyophilised, the residue is dissolved in dilute HCl, lyophilised again and then it is obtained as colourless prisms by vapour diffusion of Et2O in a 1:1 (v/v) mixture of MeOH/EtOH in which the hydrochloride is dissolved [Del Re Acta Cryst B 33 3289 1977]. The iodide salt, m ~ 150o(dec), is obtained by dissolving it in 50% aqueous EtOH and adding ~3.5 volumes of absolute EtOH. The bromide salt has m 140o(dec) [Toennies & Kolb J Amer Chem Soc 67 849 1945].
DL-METHIONINE METHYLSULFONIUM CHLORIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3422 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 | admin@zhanyaobio.com | China | 2136 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from DL-METHIONINE METHYLSULFONIUM CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-10-19 | Methyl Methanesulfonate
1115-84-0
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2020-03-16 | L-Methionine-S-Methyl SulfoniuM Chloride
1115-84-0
|
US $1.00-0.00 / KG | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- Methyl Methanesulfonate
1115-84-0
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- L-Methionine-S-Methyl SulfoniuM Chloride
1115-84-0
- US $1.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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