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COMU
- CAS No.
- 1075198-30-9
- Chemical Name:
- COMU
- Synonyms
- {{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-4-morpholinomethylene}dimethylammonium;COMU(R) 97%;COMU ISO 9001：2015 REACH;elagolix intermediate 13;COMU NOVABIOCHEM(R) 25 G;(2-oxime cyanoacetate ethyl ester) - N, N-dimethylmorpholineurea hexafluorophosphate;[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium;(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate;4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate;1-[1-(Cyano-2-ethoxy-2-oxoethylideneaMinooxy)-diMethylaMino-Morpholino]-uroniuM hexafluorophosphate
- CBNumber:
- CB72505584
- Molecular Formula:
- C12H19F6N4O4P
- Molecular Weight:
- 428.2678402
- MDL Number:
- MFCD11975052
- MOL File:
- 1075198-30-9.mol
Last updated:2023-12-04 13:20:27
| Melting point | ca 160℃ |
|---|---|
| storage temp. | Store at -15°C to -25°C. |
| solubility | Soluble in DMF 1mmol in 2mL. |
| form | Powder or Solid |
| color | White to pale yellow |
| Sensitive | Air & Moisture Sensitive |
| InChI | InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-; |
| InChIKey | GPDHNZNLPKYHCN-DZOOLQPHSA-N |
| SMILES | C1N(/C(/O/N=C(\C(OCC)=O)/C#N)=[N+](\C)/C)CCOC1.[P-](F)(F)(F)(F)(F)F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934 99 90 | |||||||||
| NFPA 704 |
|
COMU price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.51085 | COMU? 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminomorpholino)]uronium | 1075198-30-9 | 25g | $223 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.51085 | COMU? 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminomorpholino)]uronium | 1075198-30-9 | 100g | $667 | 2024-03-01 | Buy |
| Sigma-Aldrich | 712191 | COMU? 97% | 1075198-30-9 | 5g | $77.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 712191 | COMU? 97% | 1075198-30-9 | 25g | $279 | 2024-03-01 | Buy |
| Sigma-Aldrich | 712191 | COMU? 97% | 1075198-30-9 | 100g | $739 | 2024-03-01 | Buy |
COMU Chemical Properties,Uses,Production
Description
COMU is a third-generation uronium-type coupling reagent based on ethyl 2-cyano-2-(hydroxylamine)acetate (Oxyma) and a morpholino carbon skeleton. The presence of the morpholino group has a marked influence on the reagent's solubility, stability, and reactivity. COMU performed exceptionally well in the presence of only 1 equiv of base, confirming the effect of the hydrogen bond acceptor in the reaction. The by-products of COMU are water soluble and easily removed, making it an excellent choice of coupling reagent for solution-phase peptide synthesis[1].
Uses
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate is used as a coupling reagent in the peptide synthesis. It is suitable for solution phase & solid phase peptide synthesis, visual or colorimetric reaction monitoring possible.
Uses
COMU – Safer and More Efficient Peptide Coupling Reagent
Advantages
- Equal or even superior performance to HATU
- Non-explosive (does not contain benzotriazole moiety)
- Suitable for solution phase & solid phase peptide synthesis
- Utmost retention of configuration – low to non-existent racemization
- High solubility and stability in typical solvents
- Visual or colorimetric reaction monitoring possible
- Easy removal of water-soluble by-products
General Description
This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention".
References
[1] Ayman El-Faham, Fernando Albericio. “COMU: A third generation of uronium-type coupling reagents.” Journal of Peptide Science 16 1 (2009): 6–9.
COMU Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 139)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| Shanghai Z&T Chemical Co., Ltd | +86-21-33561011 13818804961 | Sales@ztchemical.com.cn | China | 402 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12431 | 58 |
Related articles
- The process of COMU coupling reaction.
- COMU, a uronium-type coupling reagent, is the most influential representative of the Oxyma-based family of coupling reagents.
- Dec 4，2023
- An efficient Coupling Reagent: COMU
- COMU is a more efficient alternative to classical benzotriazole immonium salts regarding racemization suppression, coupling ef....
- Dec 4，2023
View Lastest Price from COMU manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-01 | COMU
1075198-30-9
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2022-09-24 | COMU
1075198-30-9
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-07-13 | COMU
1075198-30-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate
1-[1-(Cyano-2-ethoxy-2-oxoethylideneaMinooxy)-diMethylaMino-Morpholino]-uroniuM hexafluorophosphate
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium Hexafluorophosphate (This product is only available in Japan.)
COMU(R) 97%
elagolix intermediate 13
COMU
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium
[[(Z)-(1-Cyano-2-ethoxy-2-oxo-ethylidene)amino]oxy-morpholino-methylene]-dimethyl-ammonium hexafluorophosphate
[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium
COMU ISO 9001：2015 REACH
COMU NOVABIOCHEM(R) 25 G
COMU
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium,98%
4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate
{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosp
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium(COMU?)
{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-4-morpholinomethylene}dimethylammonium
[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium,hexafluorophosphate
4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate(V)
N-1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholin-4-yl)uronium hexafluorophosphate
(2-oxime cyanoacetate ethyl ester) - N, N-dimethylmorpholineurea hexafluorophosphate
1075198-30-9
C12H19N4O4PF6
C12H19F6N4O4P
C12H19N4O4F6P