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LY2886721

CAS No.
1262036-50-9
Chemical Name:
LY2886721
Synonyms
CS-367;4-d][1;LY2886721;N-(3-((4aS;LY2886721HCL;7aS)-2-amino-4a;LY2886721, >=98%;LY2886721 HCL SALT;LY2886721 USP/EP/BP;LY2886721/LY-2886721
CBNumber:
CB72516034
Molecular Formula:
C18H16F2N4O2S
Molecular Weight:
390.41
MDL Number:
MFCD22124078
MOL File:
1262036-50-9.mol
Last updated:2023-05-21 10:59:17

LY2886721 Properties

Density 1.57
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥19.52 mg/mL in DMSO
form solid
pka 10.08±0.70(Predicted)
FDA UNII 2CQ62IWB67

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

LY2886721 price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21599 LY2886721 ≥98% 1262036-50-9 1mg $49 2024-03-01 Buy
Cayman Chemical 21599 LY2886721 ≥98% 1262036-50-9 5mg $202 2024-03-01 Buy
Cayman Chemical 21599 LY2886721 ≥98% 1262036-50-9 10mg $380 2024-03-01 Buy
Cayman Chemical 21599 LY2886721 ≥98% 1262036-50-9 25mg $651 2024-03-01 Buy
Usbiological 474129 LY 2886721 1262036-50-9 100mg $1890 2021-12-16 Buy
Product number Packaging Price Buy
21599 1mg $49 Buy
21599 5mg $202 Buy
21599 10mg $380 Buy
21599 25mg $651 Buy
474129 100mg $1890 Buy

LY2886721 Chemical Properties,Uses,Production

Uses

LY2886721 is a BACE inhibitor used to treat Alzheimer's disease.

Biological Activity

ly2886721 is an oral and furothiazine-based inhibitor of β site-amyloid protein cleaving enzyme (bace) with ic50 of 20.3nm. this product has the potency for the treatment of alzheimer's disease.bace, also known as beta-secretase 1, is an aspartic-acid protease that plays important role in the formation of myelin sheaths in peripheral nerve cells.in pdapp mice, oral administration of ly2886721 resulted in a reduction in brain aβ, c99 and sappβ in a dose-dependent pattern 2. aβ levels in the brain were decreased by 20% -65% as compared with the vehicle-treated groups 3 hours after treatment of ly2886721 at a dosage of 3-30 mg/kg per mice. in addition, ly2886721 significantly lowers plasma and csf aβs in the mad study 1.

in vitro

treatment of ly2886721 leads to the inhibition of aβ in hek293swe with ic50 of 18.7nm and pdapp neuronal culture with ic50 10.7 nm1. ly2886721 decreases csf sappβ and increases csf sappα in a dose- dependent manner 2.

target

BACE

References

1. vassar r. bace1 inhibitor drugs in

1262037-71-7
1262036-50-9
Synthesis of LY2886721 from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-
Global( 117)Suppliers
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career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Hangzhou FandaChem Co.,Ltd.
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Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3012 60
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Hubei Jusheng Technology Co.,Ltd.
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Alchem Pharmtech,Inc.
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CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
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Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58

View Lastest Price from LY2886721 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LY2886721 pictures 2019-12-20 LY2886721
1262036-50-9
US $1.00 / KG 1KG 99% 100kgs Career Henan Chemical Co
  • LY2886721 pictures
  • LY2886721
    1262036-50-9
  • US $1.00 / KG
  • 99%
  • Career Henan Chemical Co

LY2886721 Spectrum

LY2886721 N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide LY2886721 HCL SALT LY2886721HCL N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide LY2886721 LY2886721, >=98% N-(3-((4aS,7aS)-2-aMino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinaMide LY2886721/LY-2886721 N-(3-((4AS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl) CS-367 3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide 4-d][1 7aS)-2-amino-4a 7a-tetrahydro-4H-furo[3 LY 2886721;LY-2886721;N-(3-((4AS;7AS)-2-AMINO-4A;5;7;7A-TETRAHYDRO-4H-FURO[3;4-D][1;3]THIAZIN-7A-YL)-4-FLUOROPHENYL)-5-FLUOROPICOLINAMIDE N-(3-((4aS 2-Pyridinecarboxamide, N-[3-[(4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro- LY2886721 USP/EP/BP N-(3-((4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-fluoropicolinamide 1262036-50-9 262036-49-6 C18H16F2N4O2S Inhibitors