Isoescin IB
- CAS No.
- 219944-46-4
- Chemical Name:
- Isoescin IB
- Synonyms
- Aescin D;Escin IVb;Isoescin Ib;Isoescin IB(Isoaescin IB);Escin Impurity 4（Isoescin IB）;Aescin D，Isoescin Ib,Escin ivb;Escin,inhibit,Inhibitor,Escin IB,Isoescin IB;β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-28-(acetyloxy)-16,22,23-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-;(3beta,4beta,16alpha,21beta,22alpha)-28-(Acetyloxy)-16,22,23-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-beta-D-glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranosiduronic acid
- CBNumber:
- CB72554315
- Molecular Formula:
- C55H86O24
- Molecular Weight:
- 1131.26
- MDL Number:
- MFCD12031630
- MOL File:
- 219944-46-4.mol
| Boiling point | 1148.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.46 |
| solubility | Soluble in methanol; |
| pka | 2.63±0.70(Predicted) |
| form | powder |
| color | White |
| Water Solubility | slightly soluble in water |
| FDA UNII | 63505RAS3F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H332 |
| Precautionary statements | P301+P312+P330-P304+P340+P312 |
Isoescin IB price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL83863 | Isoescin IB phyproof? Reference Substance | 219944-46-4 | 10MG | $709 | 2024-03-01 | Buy |
| Usbiological | 300477 | Isoescin IB | 219944-46-4 | 5mg | $490 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259321 | Isoescin IB 95% | 219944-46-4 | 10mg | $552.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI145247 | Isoescin IB | 219944-46-4 | 2mg | $98.76 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI145247 | Isoescin IB | 219944-46-4 | 5mg | $197.5 | 2021-12-16 | Buy |
Isoescin IB Chemical Properties,Uses,Production
Chemical Properties
The saponins found in escin exist in two forms, β-escin and α-escin, which can be distinguished by melting point, hemolytic index, specific rotation and solubility in water. β-Escin (mainly consisting of escin Ia and escin Ib) is the major active ingredient in horse chestnut seeds extracts.
Pharmacological Action
Escin exhibits remarkable anti-inflammatory, anti-edematous and vasoprotective properties in a dose-dependent manner which are quite evident at 10-6–10-7 M. Escin has been traditionally used to treat conditions such as chronic venous insufficiency, hemorrhoids, inflammation and cerebral ischemic damage.
Escin Ia & Isoescin Ib
As the minor component of escin, α-escin (mainly consisting of isoescin Ia and isoescin Ib) exhibits lower bioactivity. Similar to isoescin Ia is the isomer of escin Ia, Isoescin Ib is an isomer of escin Ib. Both of them were found to be isomerizable in vitro. Escin Ib and isoescin Ib exhibits stronger pharmacological activity than escin Ia and isoescin Ia. As the result, pharmacokinetics study of them would be helpful for improving the practice of escin application.
Isoescin IB Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
Related articles
- What is Isoescin IB?
- Escin (aescin) is a mixture of triterpene saponins and constitutes the major active ingredient in horse chestnut (Aesculus hip....
- Feb 13，2020
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