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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

CAS No.
1000669-72-6
Chemical Name:
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
Synonyms
CS-468;KW 2449;KW-2449 100MG;KW2449;KW 2449;KW-2449;KW 2449; KW2449;KW-2449 hydrochloride HCL;[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone;Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-;3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE
CBNumber:
CB72554360
Molecular Formula:
C20H20N4O
Molecular Weight:
332.4
MDL Number:
MFCD18385006
MOL File:
1000669-72-6.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:16

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Properties

Boiling point 604.1±55.0 °C(Predicted)
Density 1.28
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
form solid
pka 13.76±0.40(Predicted)
color Pale yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
FDA UNII 2D9N67F58G

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22207 KW 2449 ≥98% 1000669-72-6 5mg $35 2024-03-01 Buy
Cayman Chemical 22207 KW 2449 ≥98% 1000669-72-6 10mg $67 2024-03-01 Buy
Cayman Chemical 22207 KW 2449 ≥98% 1000669-72-6 25mg $149 2024-03-01 Buy
Cayman Chemical 22207 KW 2449 ≥98% 1000669-72-6 50mg $263 2024-03-01 Buy
AK Scientific X7371 (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone 1000669-72-6 50mg $290 2021-12-16 Buy
Product number Packaging Price Buy
22207 5mg $35 Buy
22207 10mg $67 Buy
22207 25mg $149 Buy
22207 50mg $263 Buy
X7371 50mg $290 Buy

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties,Uses,Production

Description

KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3

Definition

ChEBI: [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is a member of indazoles.

target

FLT3

References

Shiotsu et al. (2007) KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1, and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo; Blood; 110 1832 Shiotsu et al. (2009) KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation; Blood; 114 1607 Pratz et al. (2009) A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response; Blood; 113 3938

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 101)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
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Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
BOC Sciences
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Chongqing Chemdad Co., Ltd
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CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58

View Lastest Price from [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone pictures 2019-07-06 [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
1000669-72-6
US $2000.00-1950.00 / KG 1KG 98% 100kg Career Henan Chemical Co

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Spectrum

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone KW 2449 (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride KW-2449;KW 2449; KW2449 [4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone KW-2449 100MG {4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone 3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE KW2449;KW 2449 CS-468 Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl- [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone USP/EP/BP KW-2449 hydrochloride HCL 1000669-72-6 Inhibitors Inhibitor