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CAY10505

CAY10505 Structure
CAY10505 structure
CAS No.
1218777-13-9
Chemical Name:
CAY10505
Synonyms
CAY10505;CAY10505, >=98%;CAY10505 CAY-10505;CAY10505 USP/EP/BP;(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;(5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)-;CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CBNumber:
CB72561463
Molecular Formula:
C14H8FNO3S
Molecular Weight:
289.28
MDL Number:
MFCD00640727
MOL File:
1218777-13-9.mol
MSDS File:
SDS
Last updated:2023-09-04 15:50:00
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CAY10505 Properties

Density 1.466
storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL in DMSO
form solid
pka 7.21±0.20(Predicted)
FDA UNII S8TQU87RAT

CAY10505 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C226995 CAY10505 1218777-13-9 10mg $50 2021-12-16 Buy
ChemScene CS-5662 CAY10505 99.79% 1218777-13-9 10mg $50 2021-12-16 Buy
ApexBio Technology B2182 CAY10505 1218777-13-9 25mg $70 2021-12-16 Buy
ChemScene CS-5662 CAY10505 99.79% 1218777-13-9 25mg $90 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001505 CAY-10505 95.00% 1218777-13-9 1MG $135.45 2021-12-16 Buy
Product number Packaging Price Buy
C226995 10mg $50 Buy
CS-5662 10mg $50 Buy
B2182 25mg $70 Buy
CS-5662 25mg $90 Buy
KIN0001505 1MG $135.45 Buy

CAY10505 Chemical Properties,Uses,Production

Uses

CAY10505 is a phosphoinositide 3-kinase gamma (PI3Kγ) specific inhibitor and improves hypertension-associated vascular endothelial dysfunction.

Biological Activity

cay10505 is a potent and selective pi3kγ inhibitor (ic50= 30 nm)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in neurons treated with 3.5 μm ba, 200 nm cay10505 partially reduced the baicalein-induced akt phosphorylation. [1]in hypertensive rats, cay10505 at 0.6 mg.kg-1 p.o. exhibited the following effects 1) effectively reduced mabp; 2) significantly ameliorated vascular endothelium dysfunction in hypertensive rats in combination of doca; 3) prominently increased serum nitrite and/or nitrate concentrations.4) prevented hypertension-induced attenuation of ach-induced endothelium-dependent relaxation.[2]

References

[1] tyagi s, sharma s, budhiraja rd. effect of phosphatidylinositol 3-kinase-γ inhibitor cay10505 in hypertension, and its associated vascular endothelium dysfunction in rats. can j physiol pharmacol. 2012 jul;90(7):881-5.
[2] sun yy, lin sh, lin hc et al. cell type-specific dependency on the pi3k/akt signaling pathway for the endogenous epo and vegf induction by baicalein in neurons versus astrocytes. plos one. 2013 jul 19;8(7):e69019.

CAY10505 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10505 Suppliers

Global( 80)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		+86-86-22-87899925 +86-8618522618860 18522618860@163.com China 694 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Hubei Jusheng Technology Co.,Ltd. 		58
career henan chemical co 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from CAY10505 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione pictures 2019-12-23 (5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
1218777-13-9
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co

CAY10505 Spectrum

CAY10505(1218777-13-9)MSCAY10505(1218777-13-9)1HNMR

1218777-13-9(CAY10505)Related Search:

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Selumetinib PF-562271 SGX-523

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CAY10505 (5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione (E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione CAY10505, >=98% 2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)- CAY10505 USP/EP/BP CAY10505 CAY-10505 1218777-13-9 Akt mTOR PI3K PI3K/Akt/mTOR Inhibitors