AR-M 1000390 hydrochloride
- CAS No.
- 209808-47-9
- Chemical Name:
- AR-M 1000390 hydrochloride
- Synonyms
- ARM-390;ARM-390HCl;AR-M1000390 HCl;ARM390 Hydrochloride;ARM 390;ARM-390;ARM390;AR-M 1000390 hydrochloride;N,N-Diethyl-4-(phenyl-4-piperidinylideneMethyl)benzaMide Hydrochloride;N,N-Diethyl-4-(phenyl(piperidin-4-ylidene)methyl)benzamide hydrochloride;Benzamide,N,N-diethyl-4-(phenyl-4-piperidinylidenemethyl)-,monohydrochloride;N,N-Diethyl-4-[phenyl(4-piperidinylidene)methyl]benzamide hydroch loride (1:1)
- CBNumber:
- CB72565926
- Molecular Formula:
- C23H29ClN2O
- Molecular Weight:
- 384.95
- MDL Number:
- MFCD20926357
- MOL File:
- 209808-47-9.mol
AR-M 1000390 hydrochloride price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4335 | AR-M1000390hydrochloride ≥97%(HPLC) | 209808-47-9 | 10 | $193 | 2021-12-16 | Buy |
| Usbiological | 254661 | AR-M 1000390 hydrochloride | 209808-47-9 | 10mg | $438 | 2021-12-16 | Buy |
| TRC | D444820 | N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamideHydrochloride | 209808-47-9 | 50mg | $605 | 2021-12-16 | Buy |
| AK Scientific | 9731DX | AR-M1000390hydrochloride | 209808-47-9 | 50mg | $340 | 2021-12-16 | Buy |
| ChemScene | CS-0020750 | AR-M1000390hydrochloride 99.80% | 209808-47-9 | 50mg | $490 | 2021-12-16 | Buy |
AR-M 1000390 hydrochloride Chemical Properties,Uses,Production
Uses
N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Hydrochloride is a (arylheteroaryl)methylene]piperidine derivatives with analgesic effect.
Biological Activity
ar-m 1000390 hydrochloride is a potent and selective agonist of δ-opioid receptor with ic50 value of 0.87 nm [1].opioid receptor is a g protein-coupled receptor with opioids as ligands. δ-opioid receptor is a opioid receptor with enkephalins as its endogenous ligands and activation of δ-opioid receptor causes analgesia.ar-m 1000390 hydrochloride is a potent and selective δ-opioid receptor agonist with ic50 values of 0.87 nm, 3.8 and 7.47 μm for δ-opioid receptor, μ-opioid receptor and κ-opioid receptor, respectively [1]. in the sk-n-be neuroblastoma cell line, ar-m 1000390 inhibited forskolin-stimulated camp accumulation with ki and ec50 values of 106 and 111 nm, respectively. sustained activation of opioid receptors by ar-m1000390 produced a strong desensitization [2].in dor-egfp mice, arm390 (10 mg/kg) significantly reduced cfa-induced heat hyperalgesia at day 1 and induced complete tolerance at day 5. in arm390-tolerant mice, δ-opioid receptor uncoupled to ca2+ channels in dorsal root ganglia [3].
storage
Store at -20°C
References
[1]. wei zy, brown w, takasaki b, et al. n,n-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. j med chem, 2000, 43(21): 3895-3905.
[2]. marie n, landemore g, debout c, et al. pharmacological characterization of ar-m1000390 at human delta opioid receptors. life sci, 2003, 73(13): 1691-1704.
[3]. pradhan aa, walwyn w, nozaki c, et al. ligand-directed trafficking of the -opioid receptor in vivo: two paths toward analgesic tolerance. j neurosci, 2010, 30(49): 16459-16468.
AR-M 1000390 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 993 | 55 |
View Lastest Price from AR-M 1000390 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | AR-M 1000390 hydrochloride
209808-47-9
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
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- AR-M 1000390 hydrochloride
209808-47-9
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co