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Indacaterol Maleate

Indacaterol Maleate
Indacaterol Maleate structure
CAS No.
753498-25-8
Chemical Name:
Indacaterol Maleate
Synonyms
Onbrez;ndacaterol Maleate;Indacaterol Maleate;QAB 149 Maleic Acid;IndacaterolMaleate>Indacaterol maleic acid;Indacaterol Maleate(API);Indacaterol maleate salt;Indacaterol Maleic Acid Salt;Indacaterol Maleate USP/EP/BP
CBNumber:
CB72566367
Molecular Formula:
C28H32N2O7
Formula Weight:
508.57
MOL File:
753498-25-8.mol

Indacaterol Maleate Properties

FDA UNII
2JEC1ITX7R
SAFETY
  • Risk and Safety Statements
HS Code  29339900

Indacaterol Maleate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical I0927 Indacaterol Maleate >98.0%(HPLC) 753498-25-8 20mg $119 2018-11-22 Buy
TCI Chemical I0927 Indacaterol Maleate >98.0%(HPLC) 753498-25-8 100mg $412 2018-11-22 Buy

Indacaterol Maleate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A long-acting β2 adrenoreceptor agonist and bronchodilator, for the treatment of asthma and chronic obstructive pulmonary disease.

Definition

ChEBI: A maleate salt obtained by reaction of indacaterol with one equivalent of maleic acid. Used for treatment of chronic obstructive pulmonary disease.

Clinical Use

Indacaterol is a b-adrenoceptor agonist currently approved in Europe as Onbrez, and is marketed by Novartis. It needs to be taken only once a day, unlike competitors formoterol and salmeterol. These drugs are used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Onbrez is administered via an aerosol formulation through a dry powder inhaler. A Phase III trial published in July 2010 suggested that indacaterol is significantly more effective than twice-daily formoterol in improving FEV1 and reduces the need for rescue medication.

Chemical Synthesis

The synthesis of indacaterol relies on the union of the dihydroindeneamine region and the quinolinol region of the molecule. Preparation of the dihydroindene unit of indacaterol was reported by researchers at Novartis in 2006 and is summarized in the scheme. 2,3-Dihydro-1H-inden-2-amine (59) was protected as its trifluoroacetamide 61 and was followed by Friedel–Crafts alkylation with acetylchloride to give 62. Hydrogenative carbonyl reduction of this unsymmetrical dihydroindene provided amide 63. An iterative Friedel–Crafts acylation/hydrogenation sequence was used to install the second ethyl group, giving rise to trifluoroacetamide 64. Basic hydrolysis to remove the trifluoroacetamide functionality, followed by salt formation by means of gaseous HCl furnished the dihydroindene amine 65. The synthesis of the remaining portion of the molecule starts from 8-hydroxyquinoline (66). Friedel–Crafts alkylation with acetylchloride and trichloroaluminum installed the acetophenone functionality at the 5-position of the quinoline frame followed by benzyl protection of the hydroxyl group to give ether 67. Oxidation of quinoline 67 with mCPBA and acylation of the resulting N-oxide with acetic anhydride and thermal rearrangement produced quinolone 68. Bromination of the methyl ketone and subsequent asymmetric reduction provided (R)-alcohol 69. Bromohydrin 69 was then converted to the epoxide using potassium carbonate prior to amination of the epoxide with dihydroindene intermediate 65 to furnish the indacaterol skeleton 70. Hydrogenolytic debenzylation and maleate salt formation provided indacaterol maleate (XI).

Indacaterol Maleate Preparation Products And Raw materials

Raw materials

Preparation Products


Indacaterol Maleate Suppliers

Global( 163)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58
BIONNA MEDICINE CO.,LTD
18518759099
790226113@qq.com CHINA 52 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58

View Lastest Price from Indacaterol Maleate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-13 indacaterol maleate
753498-25-8
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 indacaterol maleate
753498-25-8
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02 indacaterol maleate
753498-25-8
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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