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ChemicalBook >> CAS DataBase List >>2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Structure
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene structure
CAS No.
1030825-20-7
Chemical Name:
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
Synonyms
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene;)-5-(4-fL;Canogliflozin;Canagliflozin-19;CanagliflozinINT;Canagliflozin INT4;2-(5-Bromo-2-methyL;CAGLIFLOZIN IMPURITY C;Canagliflozin Bromo Imp;Canagliflozin Impurity 52
CBNumber:
CB72603549
Molecular Formula:
C18H14BrFS
Molecular Weight:
361.27
MDL Number:
MFCD21496340
MOL File:
1030825-20-7.mol
MSDS File:
SDS
Last updated:2024-04-16 14:59:45
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2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Properties

Melting point 103 °C
Boiling point 438.3±40.0 °C(Predicted)
Density 1.388
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly, Heated), Hexanes (Slightly, Heated)
form Solid
color White to Off-White
InChI InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
InChIKey VLRIERSBZHUCOW-UHFFFAOYSA-N
SMILES C1(CC2=CC(Br)=CC=C2C)SC(C2=CC=C(F)C=C2)=CC=1
FDA UNII W76HXE3GL5

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2934999090

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B5335 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene >98.0%(GC) 1030825-20-7 200mg $29 2024-03-01 Buy
TCI Chemical B5335 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene >98.0%(GC) 1030825-20-7 1g $93 2024-03-01 Buy
TRC B685970 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene 1030825-20-7 100mg $135 2021-12-16 Buy
Apolloscientific PC448035 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 98% 1030825-20-7 5g $107 2021-12-16 Buy
SynQuest Laboratories 5H66-B-00 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7 5G $172 2021-12-16 Buy
Product number Packaging Price Buy
B5335 200mg $29 Buy
B5335 1g $93 Buy
B685970 100mg $135 Buy
PC448035 5g $107 Buy
5H66-B-00 5G $172 Buy

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Chemical Properties,Uses,Production

Uses

2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.

Synthesis

prepares 2-(4-fluorophenyl) thiophene III:
Prepared by Grignard reagent: N 2under protection; magnesium chips (11.7g is added in the 500mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed; 480mmol), THF (15.0mL), drips 2 p-Fluoro bromo benzenes; add the initiation reaction of 2 iodine post-heating; p-Fluoro bromo benzene (70.0g, 400mmol) is dissolved in THF (250mL), after under reflux, drip the THF solution of p-Fluoro bromo benzene; drip Bi Baowen backflow 2h, GC detection feedstock conversion complete.
synthesis of 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
Linked reaction: N 2under protection; in the 1000mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed, add 2-bromothiophene (52.2g, 320mmol), under stirring, add two (methyl ethyl diketone) palladium (23.4mg; 0.0320mmol); THF (200mL), is heated to 50 DEG C, the above-mentioned Grignard reagent prepared of rear dropping; drip to finish and be warming up to 60 DEG C; insulation 1h, GC detect to raw material reaction complete, terminate reaction.System is cooled to 30 DEG C, drips dilute hydrochloric acid (2M, 150mL) under ice-water bath, drips complete vigorous stirring 0.5h, removes ice-water bath and make system naturally rise to room temperature, stratification, water layer CH 2cl 2(100mL × 3) extract, merge organic phase saturated sodium-chloride 200mL to wash, rear drying, concentrating under reduced pressure obtain light tan solid, vacuum-drying to constant weight obtains 2-(4-fluorophenyl) thiophene III (57.4g, 312mmol), it is 98.5% that GC detects purity, and yield is 99.1%.
1H NMR(500MHz,CDCl 3)δ7.65～7.54(m,2H),7.33～7.22(m,2H),7.14～7.03(m,3H).Gc-Ms:178.1.

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Suppliers

Global( 394)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12453 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Shanghai Yingrui Biopharma Co., Ltd. 		60
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60

View Lastest Price from 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene pictures 2024-04-16 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
1030825-20-7
 US $5.00-0.10 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene pictures 2024-04-10 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
1030825-20-7
 US $0.00 / kg 1kg 98% 500kg Shanghai Joiny Pharmaceutical Co.,LTD
2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene pictures 2024-01-02 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
1030825-20-7
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd

1030825-20-7(2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene)Related Search:

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2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Thiophene, 2-[(5-broMo-2-Methylphenyl)Methyl]-5-(4-fluorophenyl)- Canagliflozin Intermediate2 Canagliflozin INT4 Canogliflozin Canagliflozin Intermediate II 2-(5-bromo-2-methyl-benzyl-(5-fluorophenyl)thiophene 2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 98% Canagliflozin Impurity 52 Canagliflozin-19 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7 1030825-20-7 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Canagliflozin Bromo Imp )-5-(4-fL 2-(5-Bromo-2-methyL Canagliflozin Bromo Impurity 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl]thiophene (Canagliflozin Impurity) 2-((5-bromo-2-methylphenyl)methyl)-5-(4-fluorophenyl)thiophe... canagliflozin impurities603 canagliflozin impurities1 Canagliflozin impurity CQ: What is Canagliflozin impurity C Q: What is the CAS Number of Canagliflozin impurity C Q: What is the storage condition of Canagliflozin impurity C 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thio CanagliflozinINT CAGLIFLOZIN IMPURITY C 2- (2-methyl-5-bromobenzyl) -5- (4-fluorobenzene) thiophene 2-(5-Bromo-2- Methylbenzyl)-5-(4-fIuorophenyl) t 1030825-20-7 C18H14BrFS Pharmaceutical intermediates 1030825-20-7