Difluoromethyl 2-pyridyl sulfone
- CAS No.
- 1219454-89-3
- Chemical Name:
- Difluoromethyl 2-pyridyl sulfone
- Synonyms
- 2-PySO2CF2H;2-[(DifL;Hu Reagent;DFM-2-pyridyl sulfone;2-Pyridyl difluoromethyl sulfone;DifluoroMethyl 2-Pyridyl Sulfone;2-(Difluoromethanesulfonyl)pyridine;2-[(DifluoroMethyl)sulfonyl]pyridine;Pyridine, 2-[(difluoroMethyl)sulfonyl]-;Difluoromethyl 2-pyridyl sulfone 97% (HPLC)
- CBNumber:
- CB72614473
- Molecular Formula:
- C6H5F2NO2S
- Molecular Weight:
- 193.17
- MDL Number:
- MFCD17010193
- MOL File:
- 1219454-89-3.mol
- MSDS File:
- SDS
| Melting point | 47.0 to 51.0 °C |
|---|---|
| Boiling point | 324.4±42.0 °C(Predicted) |
| Density | 1.423±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | -2.60±0.19(Predicted) |
| form | Solid |
| color | Off-White |
| BRN | 20317604 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319 | |||||||||
| Precautionary statements | P301+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36 | |||||||||
| Safety Statements | 26-45-24/25 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Difluoromethyl 2-pyridyl sulfone price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 746061 | Difluoromethyl 2-pyridyl sulfone 97% (HPLC) | 1219454-89-3 | 1g | $137 | 2024-03-01 | Buy |
| Sigma-Aldrich | 746061 | Difluoromethyl 2-pyridyl sulfone 97% (HPLC) | 1219454-89-3 | 5g | $643 | 2024-03-01 | Buy |
| TCI Chemical | D5390 | Difluoromethyl 2-Pyridyl Sulfone >98.0%(GC) | 1219454-89-3 | 1g | $117 | 2024-03-01 | Buy |
| TRC | D446180 | 2-[(Difluoromethyl)sulfonyl]pyridine | 1219454-89-3 | 1g | $110 | 2021-12-16 | Buy |
| TRC | D446180 | 2-[(Difluoromethyl)sulfonyl]pyridine | 1219454-89-3 | 5g | $255 | 2021-12-16 | Buy |
Difluoromethyl 2-pyridyl sulfone Chemical Properties,Uses,Production
Description
Difluoromethyl 2-pyridyl sulfone, also known as Hu reagent, is a novel and efficient gem-difluoroolefination reagent for preparing gem-difluoroalkenes from both aldehydes and ketones. The fluorinated sulfinate intermediates during the gem-difluoroolefination is relatively stable, and can be halogenated in situ to afford bromo- and iododifluoromethyl compounds. It can also act as nucleophilic difluoro(sulfonato)methylation reagent for the synthesis of α,α-difluorosulfonates from aldehydes, and alkyl halides and triflates.
Uses
2-[(Difluoromethyl)sulfonyl]pyridine is a new novel gem-difluoroolefination reagent for both aldehydes and ketones.
Uses
Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions. Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.
Reactions
(1) gem-Difluoroolefination of aldehydes and ketones.
(2) Halodifluoromethylation of aldehydes and ketones.
(3) (Fluorosulfonyl)difluoromethylation of aldehydes and ketones.
(4) Difluoro(sulfonato)methylation of alkyl halides and triflates.
(5) Aromatic difluoromethylation
General Description
Difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is a reagent used in the gem-difluoroolefination of aldehydes and ketones. It is also used as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides.
References
[1] WENJUN MIAO. Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2021, 23 3: 711-715. DOI:10.1021/acs.orglett.0c03939.
[2] WENJUN MIAO. Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2-Pyridyl Sulfone[J]. Organic Letters, 2016, 18 11: 2766-2769. DOI:10.1021/acs.orglett.6b01258.
[3] YANCHUAN ZHAO. Difluoromethyl 2-Pyridyl Sulfone: A New gem-Difluoroolefination Reagent for Aldehydes and Ketones[J]. Organic Letters, 2010, 12 7: 1444-1447. DOI:10.1021/ol100090r.
Difluoromethyl 2-pyridyl sulfone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 7836 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
View Lastest Price from Difluoromethyl 2-pyridyl sulfone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-15 | Difluoromethyl 2-pyridyl sulfone
1219454-89-3
|
US $0.10-0.10 / kg | 0.0005kg | 99% | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
![Pyridine, 2-[(difluoroMethyl)sulfonyl]- pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/0bc0520c-a286-4e9e-84c3-af83db181b94.png) |
2020-01-17 | Pyridine, 2-[(difluoroMethyl)sulfonyl]-
1219454-89-3
|
US $3.00 / KG | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co |
-
- Difluoromethyl 2-pyridyl sulfone
1219454-89-3
- US $0.10-0.10 / kg
- 99%
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Pyridine, 2-[(difluoroMethyl)sulfonyl]-
1219454-89-3
- US $3.00 / KG
- 98%
- Career Henan Chemical Co