BML-275
- CAS No.
- 1219168-18-9
- Chemical Name:
- BML-275
- Synonyms
- CS-1883;Dorsomorph;BML-275(2HCL);Compound C 2HCl;Dorsomorphin HCl;BML-275,Compound C;BML-275 dihydrochloride;Dorsomorphin-2HCl BML-275;BML-275 Dorsomorphin 2HCL;Compound C dihydrochloride
- CBNumber:
- CB72614842
- Molecular Formula:
- C24H27Cl2N5O
- Molecular Weight:
- 472.41008
- MDL Number:
- MFCD11112197
- MOL File:
- 1219168-18-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
BML-275 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21207 | Dorsomorphin (hydrochloride) ≥98% | 1219168-18-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21207 | Dorsomorphin (hydrochloride) ≥98% | 1219168-18-9 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 21207 | Dorsomorphin (hydrochloride) ≥98% | 1219168-18-9 | 10mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 21207 | Dorsomorphin (hydrochloride) ≥98% | 1219168-18-9 | 25mg | $343 | 2024-03-01 | Buy |
| TRC | D534910 | DorsomorphinDihydrochloride | 1219168-18-9 | 50mg | $425 | 2021-12-16 | Buy |
BML-275 Chemical Properties,Uses,Production
Description
Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.
Uses
Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
storage
Room temperature (desiccate)
BML-275 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |