C3, HUMAN
- CAS No.
- 80295-41-6
- Chemical Name:
- C3, HUMAN
- Synonyms
- C3, HUMAN;C3 Protein;COMPLEMENT C3;COMPLEMENT 3, HUMAN;COMPLEMENT C3, HUMAN;complement c3 from human serum;COMPLEMENT C3 FROM HUMAN SERUMFROZEN SOL UTION
- CBNumber:
- CB7261527
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00130836
- MOL File:
- Mol file
- MSDS File:
- SDS
| storage temp. | -70°C |
|---|---|
| form | lyophilized powder |
| FDA UNII | UM18T01RY8 |
SAFETY
Risk and Safety Statements
| Hazard Codes | B |
|---|---|
| WGK Germany | 3 |
C3, HUMAN price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C2910 | Complement C3 from human serum ≥3000?C3H50 units/mg (using C3 deficient serum) | 80295-41-6 | 0.1mg | $863 | 2024-03-01 | Buy |
| Sigma-Aldrich | 204885 | Complement C3, Human Complement C3, Human, CAS 80295-41-6, is a native C3 component. Glycoprotein composed of two non-identical disulfide-bonded subunits of 115 kDa (α) and 75 kDa (β). | 80295-41-6 | 250μg | $370 | 2024-03-01 | Buy |
| Usbiological | C7850-11H | Complement C3, Human | 80295-41-6 | 10x96Tests | $1117 | 2021-12-16 | Buy |
C3, HUMAN Chemical Properties,Uses,Production
Uses
Complement C3 is important in complement activation through the classical and alternative pathways. Complement C3 has been used in studies of bacterial defense against the complement system. Research on streptococcus infection has shown that Streptococcal pyrogenic exotoxin B (SPE B), a cysteine protease, can prevent phagocytic activity via cleavage of the C3 and impairing the pathways of the compliment system. C3 deficiency can result in recurrent infections and immune complex disorders. Recent research has shown that inherited C3 deficiency can occur either through homozygous mutations or through compound heterozygous mutations,
Biochem/physiol Actions
Complement C3 is the third and most abundant component of the complement pathway. It plays a central role in complement activation, being involved in both the classical and alternative pathways. C3 or its proteolytic fragments mediate many biological functions such as opsonization and anaphylatoxin activities. Pro-C3 is synthesized as a large single chain of 185 kDa and is processed to a disulfide-linked heterodimer consisting of an α-chain (115 kDa) and a β-chain (70 kDa) in the plasma. C3 is cleaved by the C3 convertases in either pathway (C4b2a, C3iBb, C3bBb) to C3b (176 kDa) comprised of the large C-terminal portion of the α-chain and the β-chain. C3b interacts with other complement components to initiate the amplification cascade. Studies of C3 function have been facilitated by experimentally induced C3 deficiency in animals by injection of cobra venom factor and more recently with gene ablation technology.
C3, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
C3, HUMAN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9288 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| Sigma-Aldrich | 80 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 58 |
| Shanghai Huzhen Industrial Co., LTD | 58 |
| United States Biological | 58 |
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