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Dabrafenib Mesylate(GSK-2118436B)

Description
Dabrafenib Mesylate(GSK-2118436B)
Dabrafenib Mesylate(GSK-2118436B) structure
CAS No.
1195768-06-9
Chemical Name:
Dabrafenib Mesylate(GSK-2118436B)
Synonyms
GSK 2118436B;Dapafini mesylate;abrafenibmesylate;Dabrfenib Mesylate;GSK2118436 Mesylate;Dabrafenib Mesylate;GSK 2118436 Mesylate;GSK-2118436 Mesylate;Dabrafenib Mesylate (API);Debrafenib Mesylate (API)
CBNumber:
CB72630077
Molecular Formula:
C24H24F3N5O5S3
Formula Weight:
615.6680696
MOL File:
1195768-06-9.mol

Dabrafenib Mesylate(GSK-2118436B) Properties

form 
White solid.
FDA UNII
B6DC89I63E
NCI Dictionary of Cancer Terms
dabrafenib mesylate
NCI Drug Dictionary
dabrafenib mesylate

Dabrafenib Mesylate(GSK-2118436B) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 7223 Dabrafenibmesylate ≥98%(HPLC) 1195768-06-9 50 $149 2021-12-16 Buy
TRC D101005 DabrafenibMesylate 1195768-06-9 25mg $150 2021-12-16 Buy
Biosynth Carbosynth FD158016 Dabrafenib mesylate 1195768-06-9 25 mg $187.5 2021-12-16 Buy
ChemScene CS-1641 DabrafenibMesylate 99.94% 1195768-06-9 50mg $100 2021-12-16 Buy
Apolloscientific BISN0172 Dabrafenib Mesylate 1195768-06-9 10mg $129 2021-12-16 Buy

Dabrafenib Mesylate(GSK-2118436B) Chemical Properties,Uses,Production

Description

Dabrafenib Mesylate is a salt form of Dabrafenib. Dabrafenib is an inhibitor of certain mutated forms of BRAF kinase, several of which may be associated with stimulating tumour growth (e.g. the BRAF V600E mutation), and Dabrafenib is also an inhibitor of BRAF V600-mutation positive cancer cell growth, both in vitro and in vivo.

Description

Dabrafenib mesylate, sold by GlaxoSmithKline under the trade name Tafinlar, was approved by the U.S. FDA in May 2013 for the treatment of metastatic BRAF-mutant melanoma. Dabrafenib reversibly inhibits the BRAF(V600E) mutant kinase as a selective ATP-competitive inhibitor which results in tumor regression.

Uses

Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.

Definition

ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of dabrafenib and methanesulfonic acid. Used for treatment of metastatic melanoma.

Chemical Synthesis

Commercially available fluoroaniline 40 was first converted to sulfonamide 42 in 91% yield by treatment with 2,5-difluorobenzenesulfonyl chloride (41) in the presence of pyridine. Next, deprotonation of 2-chloro-4-methylpyrimidine (43) with lithium bis(trimethylsilyl)amide (LHMDS) followed by addition to ester 42 afforded chloropyrimidine 44 in 72% yield. Bromination followed by thiazole formation through the use of 2,2-dimethylpropanethioamide gave the penultimate target 45 in 80% over two steps. Chloropyrimidine 45 was subjected to SNAr conditions with ammonium hydroxide to furnish the aminopyrimidine in 88% yield, and this was followed by exposure to methanesulfonic acid to afford dabrafenib mesylate (VI) in 85% yield.

Dabrafenib Mesylate(GSK-2118436B) synthesis

75-75-2
1195765-45-7
1195768-06-9
Synthesis of Dabrafenib Mesylate(GSK-2118436B) from Methanesulfonic acid and Dabrafenib

Dabrafenib Mesylate(GSK-2118436B) Preparation Products And Raw materials

Raw materials

Preparation Products


Dabrafenib Mesylate(GSK-2118436B) Suppliers

Global( 150)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Jurong Coupling Biotechnology Co., Ltd.
13656108824
coupling278191416@hotmail.com CHINA 184 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9134 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838
chloewu@chicopharm.cn CHINA 341 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3004 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shenzhen Excellent Biotech Co., Ltd.
13480692018
ramyan@ex-biotech.com;sale@ex-biotech.com CHINA 955 58

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View Lastest Price from Dabrafenib Mesylate(GSK-2118436B) manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-13 Dabrafenib Mesylate
1195768-06-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Dabrafenib Mesylate
1195768-06-9
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2020-04-28 Dabrafenib Mesylate(GSK-2118436B)
1195768-06-9
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd

1195768-06-9(Dabrafenib Mesylate(GSK-2118436B))Related Search:


  • Dabrafenib Mesylate (GSK-2118436)
  • Dabrafenib Mesylate(GSK-2118436B)
  • Dabrafenib Mesylate
  • GSK 2118436 Mesylate
  • GSK 2118436B
  • GSK2118436 Mesylate
  • GSK-2118436 Mesylate
  • Dabrafenib Mesylate (API)
  • GSK 2118436 methanesulfonate salt
  • N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide methanesulfonate
  • Dapafini mesylate
  • DABRAFENIB MESYLATE (GSK 2118436B);GSK-2118436 MESYLATE;GSK2118436 MESYLATE;GSK 2118436 MESYLATE
  • N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide methanesulfonate
  • GSK2118436 Ms salt, Dabrafenib Ms salt, GSK2118436A Ms salt
  • Debrafenib Mesylate (API)
  • Dabrafenib, Methanesulfonate Salt
  • Dabrfenib Mesylate
  • N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzen
  • Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-, methanesulfonate (1:1)
  • Dabrafenib Mesylate(GSK-2118436B) fandachem
  • abrafenibmesylate
  • Dabrafenib Mesylate (GSK2118436 Mesylate
  • N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonic acid
  • 1195768-06-9
  • C23H20F3N5O2S2CH4O3S
  • C24H24F3N5O5S3
  • Raf B protein kinase inhibitor
  • API
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