1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione
- CAS No.
- 37468-32-9
- Chemical Name:
- 1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione
- Synonyms
- ALLO-1;ALLO1,ALLO 1;1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione;3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-Imidazolidinedione;2,4-Imidazolidinedione, 3-(4-chlorophenyl)-5-methyl-1-(phenylmethyl)-
- CBNumber:
- CB72638846
- Molecular Formula:
- C17H15ClN2O2
- Molecular Weight:
- 314.77
- MDL Number:
- MFCD19441284
- MOL File:
- 37468-32-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS09 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H317-H319-H400 | |||||||||
Precautionary statements | P273-P280-P305+P351+P338 | |||||||||
Hazard Codes | Xn,N | |||||||||
Risk Statements | 22-50 | |||||||||
Safety Statements | 61 | |||||||||
RIDADR | UN 3077 9 / PGIII | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0381 | ALLO-1 ≥98% (HPLC) | 37468-32-9 | 25mg | $503 | 2023-06-20 | Buy |
Sigma-Aldrich | SML0381 | ALLO-1 ≥98% (HPLC) | 37468-32-9 | 5mg | $113 | 2022-05-15 | Buy |
Cayman Chemical | 17776 | ALLO-1 ≥98% | 37468-32-9 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 17776 | ALLO-1 ≥98% | 37468-32-9 | 5mg | $98 | 2024-03-01 | Buy |
Cayman Chemical | 17776 | ALLO-1 ≥98% | 37468-32-9 | 10mg | $178 | 2024-03-01 | Buy |
1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Chemical Properties,Uses,Production
Uses
ALLO-1 is a small molecule antagonist that inhibits drug-resistant mutant of Smoothened (Smo), related to cancers.
Biological Activity
allo-1 is a smo antagonist.hedgehog (hh) proteins are important development regulators that bind the cell-surface protein, which allows the activation of a gpcr-like receptor, smoothened (smo). in vertebrates, the smo activation finally results in the activation of the zinc-finger transcription factors of the gli family. in addition, the overactivation of smo may lead to certain cancers.
Biochem/physiol Actions
ALLO-1 is a Smoothened (Smo) antagonist that inhibits both wild-type and mutant Smo, including D473H SMO mutant. ALLO-1 binds to a different domain of Smo than other known Smo ligands.
in vitro
previous study found that allo-1 and its close analog allo-2 could inhibit smo agonist hh-ag 1.5-induced luciferase expression in tm3-gli-luc cells. the potency of allo-1 did not change when either low dose or high dose of hh-ag 1.5 was used, in contrast to other known smo antagonists that are strong sag or hh-ag 1.5 competitors. moreover, it was found that in contrast to gdc-0449, both allo-1 and allo-2 inhibited wild-type and the d477g mutant with only around2-fold shift in ic50, indicating that the d477g mutation did not significantly interfere with the binding of allo-1 and allo-2 to smo. in addition, allo-1 as well as allo-2 were able to inhibit both wild-type and d473h mutant human smo with similar potencies [1].
IC 50
50 nm for wile type smo
References
[1] tao, h. ,jin, q.,koo, d.i., et al. small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. chemistry & biology 18, 432-437 (2011).
1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Preparation Products And Raw materials
Raw materials
Preparation Products
1-benzyl-3-(4-chlorophenyl)-5-MethyliMidazolidine-2,4-dione Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 18108052721 | 2850505130@qq.com | China | 5182 | 58 |