HPI-4,Hedgehog Pathway Inhibitor 4
- CAS No.
- 302803-72-1
- Chemical Name:
- HPI-4,Hedgehog Pathway Inhibitor 4
- Synonyms
- HPI-4;iobrevin A;HPI-4;HPI 4;Ciliobrevin A;Ciliobrevin A(HPI4);HPI-4 (Ciliobrevin A);Hedgehog Pathway Inhibitor 4;HPI-4,Hedgehog Pathway Inhibitor 4;HPI4,Hedgehog,HPI 4,Ciliobrevin A,inhibit,Inhibitor;2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
- CBNumber:
- CB72644957
- Molecular Formula:
- C17H9Cl2N3O2
- Molecular Weight:
- 358.18
- MDL Number:
- MFCD01911757
- MOL File:
- 302803-72-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50/53 | |||||||||
| Safety Statements | 60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
HPI-4,Hedgehog Pathway Inhibitor 4 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H4541 | HPI-4 ≥98% (HPLC) | 302803-72-1 | 5mg | $134 | 2024-03-01 | Buy |
| Sigma-Aldrich | H4541 | HPI-4 ≥98% (HPLC) | 302803-72-1 | 25mg | $431 | 2024-03-01 | Buy |
| Cayman Chemical | 22587 | Ciliobrevin A ≥98% | 302803-72-1 | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 22587 | Ciliobrevin A ≥98% | 302803-72-1 | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 22587 | Ciliobrevin A ≥98% | 302803-72-1 | 25mg | $252 | 2024-03-01 | Buy |
HPI-4,Hedgehog Pathway Inhibitor 4 Chemical Properties,Uses,Production
Description
Ciliobrevin A is a hedgehog pathway inhibitor that blocks sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 μM). It disrupts primary cilia formation and inhibits the dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic ATPases associated with various cellular activities (AAA+) family. Ciliobrevin A also inhibits mammalian target of rapamycin complex 1 (mTORC1) activity in uninfected and human cytomegalovirus (HCMV)-infected cells, suggesting that mTORC1 activation requires dynein-dependent transport for cellular activation.
Uses
Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling.
Uses
Hedgehog pathway inhibitor (HP1-4) has been used for the inhibition of dynein ATPase in Leishmania.
Biochem/physiol Actions
HPI-4 is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. A key signaling molecule in HH pathway, Smoothened (Smo), has been the target of pharmacological intervention, which has resulted in multiple Smo antagonists including Cyclopamine. However, the oncogenic form of Smo is resistant to Cyclopamine, so the identification of inhibitors of downstream effectors, such as the transcription factors Gli1 and Gli2, is important. Four small molecules were identified to inhibit HH downstream of Smo, HPI-1, HPI-2, HPI-3, and HPI-4. HPI-4 blocked HH pathway activation by SAG, decreased Smo ciliary accumulation, decreased HH activity in a consitutively active HH cell line, and decreased Gli1 and Gli2, processing, and stability. HPI-4 inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling. Cilia in HPI-4-treated cells were either truncated or absent. The mechanism of action of HPI-4 is hypothesized to be directly through perturbation of ciliogenesis, leading to disruption of Gli1/Gli2 activity, which is distinctly different from that of Cyclopamine.
storage
Store at +4°C
HPI-4,Hedgehog Pathway Inhibitor 4 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from HPI-4,Hedgehog Pathway Inhibitor 4 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | HPI-4,Hedgehog Pathway Inhibitor 4
302803-72-1
|
US $1.00 / g | 1g | 99% | 20kg | Career Henan Chemical Co |
-
- HPI-4,Hedgehog Pathway Inhibitor 4
302803-72-1
- US $1.00 / g
- 99%
- Career Henan Chemical Co