LGK-974
- CAS No.
- 1243244-14-5
- Chemical Name:
- LGK-974
- Synonyms
- LGK-974;WNT-974;CS-1102;NVP-LGK974;LGK974 (WNT974);LGK974; LGK-974;LGK-974 USP/EP/BP;LGK974(NVP-LGK974);LGK974; LGK 974; NVP-LGK974;7'-Dichlorodihydrofluorescein diacetate
- CBNumber:
- CB72655412
- Molecular Formula:
- C23H20N6O
- Molecular Weight:
- 396.44
- MDL Number:
- MFCD27501026
- MOL File:
- 1243244-14-5.mol
| Melting point | 176 - 180°C |
|---|---|
| Boiling point | 650.9±55.0 °C(Predicted) |
| Density | 1.268±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 12.24±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | U27F40013Q |
LGK-974 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.31091 | Porcn Inhibitor IV, LGK974 - CAS 1243244-14-5 - Calbiochem A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC?? from 50 pM to 1.1 nM). | 1243244-14-5 | 5MG | $239 | 2024-03-01 | Buy |
| Cayman Chemical | 14072 | LGK974 ≥98% | 1243244-14-5 | 500μg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 14072 | LGK974 ≥98% | 1243244-14-5 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 14072 | LGK974 ≥98% | 1243244-14-5 | 5mg | $195 | 2024-03-01 | Buy |
| TRC | L397640 | LGK974 | 1243244-14-5 | 500μg | $55 | 2021-12-16 | Buy |
LGK-974 Chemical Properties,Uses,Production
Description
Porcupine (PORCN) is a membrane bound O-
Uses
LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.
Definition
ChEBI: LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a member of bipyridines, a member of pyrazines, a member of pyridines and a secondary carboxamide. It is functionally related to an acetamide.
target
PORCN
References
[1] liu j, pan s, hsieh mh, ng n, sun f, wang t, kasibhatla s, schuller ag, li ag, cheng d, li j, tompkins c, pferdekamper a, steffy a, cheng j, kowal c, phung v, guo g, wang y, graham mp, flynn s, brenner jc, li c, villarroel mc, schultz pg, wu x, mcnamara p, sellers wr, petruzzelli l, boral al, seidel hm, mclaughlin me, che j, carey te, vanasse g, harris jl. targeting wnt-driven cancer through the inhibition of porcupine by lgk974. proc natl acad sci u s a. 2013 dec 10;110(50):20224-9.
LGK-974 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
