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1-(1-Benzothiophen-4-yl)piperazine hydrochloride

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Structure
1-(1-Benzothiophen-4-yl)piperazine hydrochloride structure
CAS No.
913614-18-3
Chemical Name:
1-(1-Benzothiophen-4-yl)piperazine hydrochloride
Synonyms
1-(benzo[b]thiophen-4-yl)piperazine hydrochloride;1-Benzo[b]thien-4-yl-piperazine hydrochloride;7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one;1-Benzo[b]thien-4-ylpiperazine Monohydrochloride;1-benzo[b]thien-4-yl-;Brexpiprazole intermediate;Brexpiprazole Intermediate 2;Brexpiprazole Impurity 9 HCl;Brexpiprazole Impurity 32 HCl;1-benzo[b]thien-4-yl-, hydrochloride
CBNumber:
CB72662777
Molecular Formula:
C12H15ClN2S
Molecular Weight:
254.7789
MDL Number:
MFCD26743820
MOL File:
913614-18-3.mol
MSDS File:
SDS
Last updated:2024-03-29 16:09:00
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1-(1-Benzothiophen-4-yl)piperazine hydrochloride Properties

Melting point >250°C (dec.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Very Slightly)
form Solid
color White

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335
Precautionary statements  P261-P271
HS Code  2934999090

1-(1-Benzothiophen-4-yl)piperazine hydrochloride price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B194840 1-Benzo[b]thien-4-yl-piperazineMonohydrochloride 913614-18-3 5g $250 2021-12-16 Buy
Biosynth Carbosynth FB139272 1-Benzo[b]thien-4-ylpiperazine monohydrochloride 913614-18-3 25g $250 2021-12-16 Buy
Apolloscientific OR305616 1-(1-Benzothiophen-4-yl)piperazinehydrochloride 913614-18-3 5g $116 2021-12-16 Buy
Biosynth Carbosynth FB139272 1-Benzo[b]thien-4-ylpiperazine monohydrochloride 913614-18-3 10g $125 2021-12-16 Buy
AK Scientific V9468 1-(Benzo[b]thiophen-4-yl)piperazinehydrochloride 913614-18-3 25g $161 2021-12-16 Buy
Product number Packaging Price Buy
B194840 5g $250 Buy
FB139272 25g $250 Buy
OR305616 5g $116 Buy
FB139272 10g $125 Buy
V9468 25g $161 Buy

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Chemical Properties,Uses,Production

Uses

4-Piperazinylbenzothiophene hydrochloride is the raw material for preparing piperazine-substituted benzothiophene, which can be used for the treatment and prevention of mental diseases including central nervous system diseases.

Synthesis

1.jpg
Synthesis of 4-(1-piperazinyl)benzo[b]thiophene hydrochloride 4-Chlorobenzo[b]thiophene (5.00 g), piperazine (5.11 g), palladium acetate (II) (2.7 mg), tri-tert-butylphosphonium tetraphenylborate (6.2 mg), sodium tert-butoxide (8.548 g), and xylene (70 ml) were stirred at 120 to 130°C for 5 hours. After the reaction mixture was cooled to room temperature, water was added thereto, and the layers were separated. The xylene layer was washed with water, and then with saline. After addition of activated carbon, the mixture was stirred at room temperature for 30 minutes. After filtration of the mixture, concentrated hydrochloric acid was added to the filtrate, and the resulting mixture was stirred at room temperature for 30 minutes. The precipitated crystals were collected by filtration and dried to obtain compound. Yield: 6.94 g. 1H-NMR (DMSO-d6) δ ppm; 3.30 (4H, br.s), 3.61 (4H, br.s), 6.97 (1H, d, J = 7.8 Hz), 7.32 (1H, br. dd, J = 8.4, 7.8 Hz), 7.53 (1H, d, J = 5.6 Hz), 7.70 (1H, d, J = 8.4 Hz), 7.76 (1H, d, J = 5.6 Hz), 9.37 (1H, br.s).

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Suppliers

Global( 225)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+86-13474506593 +86-13474506593 sarah@tnjone.com China 794 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 925 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58

View Lastest Price from 1-(1-Benzothiophen-4-yl)piperazine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Benzo[b]thien-4-ylpiperazine monohydrochloride pictures 2024-04-19 1-Benzo[b]thien-4-ylpiperazine monohydrochloride
913614-18-3
 US $0.00 / Kg/Drum 10g 99% 100mt/year Jinan Finer Chemical Co., Ltd
1-(1-Benzothiophen-4-yl)piperazine hydrochloride pictures 2024-03-29 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
913614-18-3
 US $0.00 / kg 1kg 99% 20tons Shaanxi TNJONE Pharmaceutical Co., Ltd
1-(1-Benzothiophen-4-yl)piperazine hydrochloride pictures 2024-03-23 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
913614-18-3
 US $35.00-0.90 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

913614-18-3(1-(1-Benzothiophen-4-yl)piperazine hydrochloride)Related Search:

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Cinnamoyl chloride 4-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID 7-Hydroxyquinolinone 1,4-di(benzo[b]thiophen-4-yl)piperazine 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
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Piperazine, 1-benzo[b]thien-4-yl-, hydrochloride Brexpiprazole Intermediate 2 1-benzo[b]thien-4-yl- 1-benzo[b]thien-4-yl-, hydrochloride 1-(1-benzothiophen-4-yl)piperazine hydrochloride 1-Benzo[b]thien-4-yl-piperazinel HCl 1-(1-benzothiophene-4-yl)piperazine monohydrochloride PIPERAZINE, 1-BENZO[B]THIEN-4-YL,HYDROCLORIDE 1-(1-Benzothiophene-4-Yl)Piperazine Hydrochloroide - 1-(4-Benzothienyl)piperazine Hydrochloride Piperazine, 1-benzo[b]thien-4-yl-, hydrochloride (1:1) Brexpiprazole intermediate 1-Benzo[b] thien-4-yl-piperzine hydrochloride 1-benzo[b]thiophene-4-yl-piperazine hydrochloride 1-Benzo[b]thien-4-yl-piperazine hydrochloride 1-Benzo[b]thien-4-ylpiperazine Monohydrochloride 7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride 1-(1-benzo[b]thien-4-yl )piperazine hydrochloride 1-benzo[b]thien-4-yl-Piperazine hydrochloride (1:1) Brexpiprazole Impurity 32 HCl 4-piperazinyl benzothiophene hydrochloride Brexpiprazole Impurity 11 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride Brexpiprazole Impurity 9 HCl 913614-18-3