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SC 144

CAS No.
895158-95-9
Chemical Name:
SC 144
Synonyms
SC144;SC-144;SC 144;CS-805;SC 144; SC144;SC144;SC-144;SC 144;2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide;Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;2-Pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
CBNumber:
CB72666896
Molecular Formula:
C16H11FN6O
Molecular Weight:
322.3
MDL Number:
MFCD25976763
MOL File:
895158-95-9.mol
Last updated:2023-05-21 10:59:17

SC 144 Properties

Density 1.53±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥16.1 mg/mL in DMSO
form solid
pka 8.87±0.43(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

SC 144 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC S199000 SC144 895158-95-9 100mg $1680 2021-12-16 Buy
Medical Isotopes, Inc. 48649 SC144 895158-95-9 100mg $2525 2021-12-16 Buy
Biorbyt Ltd orb146229 SC144 >98% 895158-95-9 1g $2691.1 2021-12-16 Buy
AK Scientific SYN5458 SC144 hydrochloride 895158-95-9 10mg $160 2021-12-16 Buy
ChemScene CS-4440 SC144 98.60% 895158-95-9 25mg $170 2021-12-16 Buy
Product number Packaging Price Buy
S199000 100mg $1680 Buy
48649 100mg $2525 Buy
orb146229 1g $2691.1 Buy
SYN5458 10mg $160 Buy
CS-4440 25mg $170 Buy

SC 144 Chemical Properties,Uses,Production

Uses

SC144 is an orally active small-molecule gp130 inhibitor.

Biological Activity

sc144 is an inhibitor of gp130 with ic50 values of 0.43 μmol/l and 0.88 μmol/l in nci/adr-res and hey cell lines, respectively [1].sc144 is a first-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer. it can substantially increase the phosphorylation of gp130 (s782) in both ovcar-8 and caov-3 cells in a time- and dose-dependent manner. the increase phosphorylation then suppresses stat3 signaling pathway since the constitutive stat3 activation is maintained by extracellular gp130 ligands, besides that, sc144 also causes substantial cell apoptosis in these cells. [1].apart from the effect on gp130, it has been reported that sc144 can directly bind and stabilize il-24 in cancer cells. additionally, sc144 has shown to have effects on cell cycle perturbation and apoptosis induction [2].sc144 may also have other cellular protein targets, resulting in multiple potential molecular mechanisms. sc144’s anticancer potency may be a sum of these effects [2].

References

[1] shili xu, fedora grande, antonio garofalo, et al. discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. molecular cancer therapeutics. 2013 (12): 937-949.
[2] shili xu, takashi oshima, toshio imada, munetaka masuda, bikash debnath, fedora grande, antonio garofalo, nouri neamati. stabilization of mda-7/il-24 for colon cancer therapy. cancer letters. 2013 feb(335):421-430.

SC 144 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 79)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
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Career Henan Chemica Co
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InvivoChem
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Nantong HI-FUTURE Biology Co., Ltd.
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TargetMol Chemicals Inc.
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Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8475 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
Angel Pharmatech, Ltd. 17317130613 3358272972@qq.com China 3235 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646 shoubull@126.com China 987 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 chaolaichem@foxmail.com China 6029 58

SC 144 Spectrum

2-Pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide SC 144 SC-144 Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide SC 144; SC144 CS-805 SC144;SC-144;SC 144 N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide SC144 895158-95-9 C16H11FN6O Inhibitors