SC 144
- CAS No.
- 895158-95-9
- Chemical Name:
- SC 144
- Synonyms
- SC144;SC-144;SC 144;CS-805;SC 144; SC144;SC144;SC-144;SC 144;2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide;Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;2-Pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
- CBNumber:
- CB72666896
- Molecular Formula:
- C16H11FN6O
- Molecular Weight:
- 322.3
- MDL Number:
- MFCD25976763
- MOL File:
- 895158-95-9.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
SC 144 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | S199000 | SC144 | 895158-95-9 | 100mg | $1680 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 48649 | SC144 | 895158-95-9 | 100mg | $2525 | 2021-12-16 | Buy |
Biorbyt Ltd | orb146229 | SC144 >98% | 895158-95-9 | 1g | $2691.1 | 2021-12-16 | Buy |
AK Scientific | SYN5458 | SC144 hydrochloride | 895158-95-9 | 10mg | $160 | 2021-12-16 | Buy |
ChemScene | CS-4440 | SC144 98.60% | 895158-95-9 | 25mg | $170 | 2021-12-16 | Buy |
SC 144 Chemical Properties,Uses,Production
Uses
SC144 is an orally active small-molecule gp130 inhibitor.
Biological Activity
sc144 is an inhibitor of gp130 with ic50 values of 0.43 μmol/l and 0.88 μmol/l in nci/adr-res and hey cell lines, respectively [1].sc144 is a first-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer. it can substantially increase the phosphorylation of gp130 (s782) in both ovcar-8 and caov-3 cells in a time- and dose-dependent manner. the increase phosphorylation then suppresses stat3 signaling pathway since the constitutive stat3 activation is maintained by extracellular gp130 ligands, besides that, sc144 also causes substantial cell apoptosis in these cells. [1].apart from the effect on gp130, it has been reported that sc144 can directly bind and stabilize il-24 in cancer cells. additionally, sc144 has shown to have effects on cell cycle perturbation and apoptosis induction [2].sc144 may also have other cellular protein targets, resulting in multiple potential molecular mechanisms. sc144’s anticancer potency may be a sum of these effects [2].
References
[1] shili xu, fedora grande, antonio garofalo, et al. discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. molecular cancer therapeutics. 2013 (12): 937-949.
[2] shili xu, takashi oshima, toshio imada, munetaka masuda, bikash debnath, fedora grande, antonio garofalo, nouri neamati. stabilization of mda-7/il-24 for colon cancer therapy. cancer letters. 2013 feb(335):421-430.
SC 144 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30256 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8475 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 132020 | 58 |
Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3235 | 58 |
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. | 17771424646 | shoubull@126.com | China | 987 | 58 |
Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 6029 | 58 |