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AHU-377 (heMicalciuM salt)

CAS No.
1369773-39-6
Chemical Name:
AHU-377 (heMicalciuM salt)
Synonyms
Sacubitril Calcium;Sacubitril hemicalcium;Sacubitril calcium salt;(alphar;LCZ696-1;AHU377 Calcium Salt;AHU-377 Hemicalcium;LCZ696 Impurity 534-06;SACUBITRIL-13C4 CALCIUM;AHU-377 (heMicalciuM salt)
CBNumber:
CB72685916
Molecular Formula:
C48H56CaN2O10
Molecular Weight:
861.04364
MDL Number:
MFCD28137893
MOL File:
1369773-39-6.mol
MSDS File:
SDS
Modify Date:2022-11-11 13:01:00

AHU-377 (heMicalciuM salt) Properties

Melting point >140°C (dec.)
Density 1.24g/cm3 at 20℃
vapor pressure 0.001Pa at 20℃
storage temp. -20°C
solubility DMSO (Slightly, Heated), Methanol (Slightly)
form powder
color white to beige
LogP -0.66-2.9 at 20℃ and pH2-7

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS09
Signal word  Danger
Hazard statements  H301-H400
Precautionary statements  P273-P301+P310+P330
RIDADR  UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

AHU-377 (heMicalciuM salt) price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1380 Sacubitril calcium salt ≥98% (HPLC) 1369773-39-6 5MG $105 2022-05-15 Buy
Sigma-Aldrich SML1380 Sacubitril calcium salt ≥98% (HPLC) 1369773-39-6 25MG $410 2022-05-15 Buy
Cayman Chemical 21473 AHU377 (calcium salt) ≥98% 1369773-39-6 10mg $60 2022-04-27 Buy
Cayman Chemical 21473 AHU377 (calcium salt) ≥98% 1369773-39-6 25mg $127 2022-04-27 Buy
Cayman Chemical 21473 AHU377 (calcium salt) ≥98% 1369773-39-6 50mg $194 2022-04-27 Buy
Product number Packaging Price Buy
SML1380 5MG $105 Buy
SML1380 25MG $410 Buy
21473 10mg $60 Buy
21473 25mg $127 Buy
21473 50mg $194 Buy

AHU-377 (heMicalciuM salt) Chemical Properties,Uses,Production

Uses

Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Biochem/physiol Actions

Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.

AHU-377 (heMicalciuM salt) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 238)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29789 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 info@dakenchem.com China 17337 58
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951 CHINA 115 55
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21975 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3012 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 31281 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29922 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58

View Lastest Price from AHU-377 (heMicalciuM salt) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AHU-377 HeMicalciuM Salt pictures 2022-08-05 AHU-377 HeMicalciuM Salt
1369773-39-6
US $14.00 / Kg/Bag 1Kg/Bag 98% Weekly supply of 1000KG Wuhan Dujiang Industrial Co., Ltd.
AHU-377 (heMicalciuM salt) pictures 2022-07-05 AHU-377 (heMicalciuM salt)
1369773-39-6
US $100.00 / kg 1kg 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
AHU-377 hemicalcium salt pictures 2022-03-23 AHU-377 hemicalcium salt
1369773-39-6
US $10.00 / kg 1kg 99% 10tons Henan Guange Biotechnology Co. LTD

AHU-377 (heMicalciuM salt) Spectrum

AHU-377 (heMicalciuM salt) (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1) AHU-377 hemicalcium salt (2:1) Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate) Sacubitril Hemicalcium salt (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)- (alphaR, gammaS) -gamma-[(3- carbonyl, -1-, oxo propyl), amino]-alpha-, biphenyl, -4-, ethyl valerate, calcium salt LCZ696(valsartan + sacubitril) impurity 1 Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt (alphar 1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) gammas)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1 LCZ696-1 monocalciummono(4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy- 4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate) Calcium4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (AHU-377 hemicalcium salt) AHU377 Calcium Salt AHU-377 Hemicalcium LCZ696 Impurity 534-06 (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoicacid4-ethylestercalciumsal LCZ696 intermediates,AHU-377 (heMicalciuM salt) (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-m... SACUBITRIL-13C4 CALCIUM Sacubitril-d5 Calcium Salt Sacubitril 13C4 CalciumQ: What is Sacubitril 13C4 Calcium Q: What is the CAS Number of Sacubitril 13C4 Calcium (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt Sacubitril Calcium Sacubitril calcium salt Sacubitril hemicalcium LCZ-696 Impurity 29 calcium salt Ethyl (2R,4S)-5-(Biphenyl-4-yl)-4-(amino)-5-(3-carboxypropionyl)amino]-2-methylpentanoate, calcium salt Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate 1369773-39-6 2C24H29NO5Ca C48H56CaN2O10 Intermediates LCZ 696 Pharmaceutical Intermediates lcz696