Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1)
- CAS No.
- 251572-86-8
- Chemical Name:
- Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1)
- Synonyms
- P32/98 (hemifumarate);WEOXCUQGVBLKQX-CXOKTDEKSA-N;Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2;Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1)
- CBNumber:
- CB72721146
- Molecular Formula:
- C13H22N2O5S
- Molecular Weight:
- 318.39
- MDL Number:
- MFCD27976627
- MOL File:
- 251572-86-8.mol
Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 16887 | P32/98 (hemifumarate) ≥98% | 251572-86-8 | 1mg | $49 | 2024-03-01 | Buy |
Cayman Chemical | 16887 | P32/98 (hemifumarate) ≥98% | 251572-86-8 | 5mg | $85 | 2024-03-01 | Buy |
Cayman Chemical | 16887 | P32/98 (hemifumarate) ≥98% | 251572-86-8 | 10mg | $120 | 2024-03-01 | Buy |
TRC | P122490 | P32/98 | 251572-86-8 | 5mg | $70 | 2021-12-16 | Buy |
ApexBio Technology | C3136 | P32/98(hemifumarate) | 251572-86-8 | 5mg | $97 | 2021-12-16 | Buy |
Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Chemical Properties,Uses,Production
Uses
P32/98 is a dipeptidyl peptidase IV inhibitor which is used in hypertensive patients treated with antihpertensive drugs.
Biological Activity
ki: 126 nmp32/98 (hemifumarate) is an inhibitor of dpp iv.glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1 (glp-1) are responsible for >50% of nutrient-stimulated insulin secretion. after being released into the circulation, gip and glp-1 are quickly inactivated by the circulating enzyme dipeptidyl peptidase iv (dpp iv).
in vitro
p32/98 was found to be able to block adipogenesis dose-dependently, starting at the concentration of 100 μm, and p32/98 could completely block adipogenesis in 3t3-l1 cell line at 500 μm concentration. in addition, the inhibitory effects of p32/98 was further confirmed by detecting the expression of adipocyte markers at the end of differentiation [1].
in vivo
in previou animal study, two groups of fa/fa zucker rats were orally treated twice daily for three months with p32/98 at 20 mg/kg/day and monthly oral glucose tolerance tests (ogtts) were conducted after drug washout. results showed that after 12 weeks of p32/98 treatment, the peak ogtt blood glucose values in the treated rats averaged 8.5 mmol/l less than in the controls. in addition, the concomitant insulin resulted in an increased early-phase insulin response in the treated group. moreover, in response to an 8.8 mmol/l glucose perfusion, pancreata from controls showed no increase in insulin secretion, while pancreata from p32/98-treated animals had a 3.2-fold rise in insulin secretion [2].
References
1. han r, wang x, bachovchin w, zukowska z, osborn jw. inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation. sci rep. 2015 aug 5;5:12348. 2. j. a. pospisilik, s. g. stafford, h. u. demuth, et al. long-term treatment with the dipeptidyl peptidase iv inhibitor p32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and β-cell glucose responsiveness in vdf (fa/fa) zucker rats. diabetes 51, 943-950 (2002).
Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Preparation Products And Raw materials
Raw materials
Preparation Products
Thiazolidine,3-[(2S,3S)-2-aMino-3-Methyl-1-oxopentyl]-, (2E)-2-butenedioate (2:1) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9767 | 58 | |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24023 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
Credit Asia Chemical Co., Ltd. | 58 |
MedBioPharmaceutical Technology Inc | 58 |
Energy Chemical | 58 |
TargetMol Chemicals Inc. | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
ApexBio Technology | 58 |