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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Structure
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile structure
CAS No.
1240948-72-4
Chemical Name:
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Synonyms
Vonoprazan-3;Vonoprazan-024;TAK438 Impurity 32;Vonolazan impurity 3;Vonoprazan Impurity Ⅶ;Vonoprazan Impurity 33;TAK438 Intermediate 3;Vonoprazan Fumarate impurity G;Voronozan initiator 1 impurity I;2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
CBNumber:
CB72722688
Molecular Formula:
C11H6ClFN2
Molecular Weight:
220.63
MDL Number:
MFCD28404592
MOL File:
1240948-72-4.mol
MSDS File:
SDS
Last updated:2022-08-26 12:23:07
Request For Quotation

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Properties

Boiling point 403.0±45.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 12.88±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Chemenu CM198987 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 95% 1240948-72-4 1g $580 2021-12-16 Buy
Crysdot CD11318402 2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 95+% 1240948-72-4 1g $620 2021-12-16 Buy
Alichem 1240948724 2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1240948-72-4 1g $653 2021-12-16 Buy
Product number Packaging Price Buy
CM198987 1g $580 Buy
CD11318402 1g $620 Buy
1240948724 1g $653 Buy

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Chemical Properties,Uses,Production

Description

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is an important pharmaceutical intermediate. It can be used in the preparation of vorexanol fumarate and vonoprazan, and can also be used as a chemical raw material for the synthesis of other organic compounds.

Uses

2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity 33) is an impurity of Vonoprazan, a potassium-competitive acid blocker (P-CAB) that suppresses gastric acid secretion.

Synthesis

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is synthesised using 2-[2-(2-fluorophenyl)-2-oxoethyl]malononitrile as raw material by chemical reaction. The specific synthesis steps are as follows:
2 g of the intermediate III-1 was dissolved in 40 ml of a solution of hydrochloric acid in ethyl acetate, and the mixture was stirred at room temperature overnight. After the reaction is completed, the solvent is distilled off under reduced pressure to give the compound of 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile, 2.1 g of a white solid with a yield of 96%.
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile synthesis

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Suppliers

Global( 117)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		+86-21-68900963 sales@jinghaopharma.com CHINA 153 58
CE Pharm Co.,Ltd 		+86 13816833708 binbin.lin@cepharm.cn CHINA 52 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1320 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9641 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10326 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
career henan chemical co 		58
Standardpharm Co. Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		58
CE Pharm Co.,Ltd 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58
Antai Fine Chemical Technology Co.,Limited 		58
Hubei Ipure Biology Co., Ltd 		58

View Lastest Price from 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile pictures 2022-10-01 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
1240948-72-4
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile pictures 2021-07-13 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
1240948-72-4
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile pictures 2021-07-10 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
1240948-72-4
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

1240948-72-4(2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile)Related Search:

Vonoprazan Fumarate impurity (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol 4-Pyridinesulphonic acid 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-
PYRIDINE-4-SULFONYL CHLORIDE PYRIDINE-2-SULFONIC ACID 3-N,N-dimethylsulfamoylpyridine 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile
1-(5-(2-fluorophenyl)-1-(pyridin-2-ylsulfonyl)-1H-pyrrol-3-yl)-N- methylmethanamine fumarate 5-chloropyridine-3-sulfonyl chloride 1-methylpyridin-1-ium-4-sulfonate 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)- (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide

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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-Pyrrole-3-carbonitrile,2-chloro-5-(2-fluorophenyl)- Vonoprazan Fumarate impurity G Vonoprazan Impurity 33 Vonoprazan Impurity Ⅶ Vonoprazan-024 TAK438 Impurity 32 Vonoprazan impurity 28/2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Vonoprazan impurity SM2-A: 2-chloro-5- (2-fluorophenyl) -1H-pyrrole-3-carbonitrile Vonoprazan-3 Voronozan initiator 1 impurity I 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity） TAK438 Intermediate 3 Vonolazan impurity 3 1240948-72-4 1240948-72-4