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Mesna

Mesna
Mesna
CAS No.
19767-45-4
Chemical Name:
Mesna
Synonyms
MESNA;D 7093;mesnum;MESNEX;mitexan;mesnaum;UCB 3983;MesnaEp5;Mesna API;mistabron
CBNumber:
CB7277461
Molecular Formula:
C2H5NaO3S2
Formula Weight:
164.18
MOL File:
19767-45-4.mol

Mesna Properties

Melting point:
>240°C dec.
storage temp. 
-20?C Freezer, Under Inert Atmosphere
solubility 
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane
form 
neat
Water Solubility 
Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml).
Merck 
14,5909
BRN 
3657828
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
19767-45-4(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  KI7968000
HS Code  2930 90 98
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 1887, 2048, 2098, 1683 i.v.; 2005, 2098, 1529, 1251 i.p.; 6102, >7200, 4440, 4679 orally (Brock)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Mesna price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M1511 Sodium 2-mercaptoethanesulfonate analytical standard, ≥98.0% (titration) 19767-45-4 5g $56.1 2018-11-20 Buy
Sigma-Aldrich M1511 Sodium 2-mercaptoethanesulfonate analytical standard, ≥98.0% (titration) 19767-45-4 10g $93.2 2018-11-20 Buy
TCI Chemical M0913 Sodium 2-Mercaptoethanesulfonate >95.0%(T) 19767-45-4 10g $64 2018-11-22 Buy
TCI Chemical M0913 Sodium 2-Mercaptoethanesulfonate >95.0%(T) 19767-45-4 25g $128 2018-11-22 Buy
Alfa Aesar J63989 2-Mercaptoethane sulfonic acid sodium salt, 96% 19767-45-4 10g $86.4 2018-11-13 Buy

Mesna Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

adrenergic agonist, coronary vasodilator, Ca channel blocker

Uses

Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.

Uses

2-Mercaptoethanesulfonic acid sodium salt (Coenzyme M sodium salt, MESNA) is used as an antioxidant and cytoprotective agent in a wide variety of applications from protection from toxicity of therapeutic agents, such as cyclophosphamide to prevention from brain injury damage.

Contact allergens

Mesna is used as a mucolytic agent, and as an antidote to chloro-acetyl-aldehyde and acrolein (a bladder toxic metabolite of ifosfamide or cyclophosphamide). It hasbeen reported as a cause of occupational allergic (hand and airborne) dermatitis in nurses

Purification Methods

It can be recrystallised from H2O and does not melt below 250o. It is purified further by converting to the free acid by passing a 2M solution through an ion-exchange (Amberlite IR-120) column in the acid form, evaporating the eluate in a vacuum to give the acid as a viscous oil (readily decomposes) which can be checked by acid and SH titration. It is then dissolved in H2O, carefully neutralised with aqueous NaOH, evaporated and the salt recrystallised from H2O [Schramm J Am Chem Soc 77 6231 1955]. [Beilstein 4 IV 85.]

Mesna Preparation Products And Raw materials

Raw materials

Preparation Products


Mesna Suppliers

Global( 241)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 277 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 778 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40399 62
Arden pharmaceutical &chemical Co., Ltd +86-(0)533-3595900 13793319233
+86-(0)533-3595900 info@chems.com.cn China 670 61

View Lastest Price from Mesna manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-05-03 Mesna ada@tuskwei.com
19767-45-4
US $6.00 / 公斤 10G more than 97 whatsapp;+8617197824028 6000g/day Hebei Jiangkai Trading Co., Ltd
2018-07-25 Mesna
19767-45-4
US $20.00 / G 1KG 99% 10kg career henan chemical co

Mesna Spectrum


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