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1,2,3,4-Tetrahydroquinoline

1,2,3,4-Tetrahydroquinoline Structure
1,2,3,4-Tetrahydroquinoline structure
CAS No.
635-46-1
Chemical Name:
1,2,3,4-Tetrahydroquinoline
Synonyms
Tetrahydroquinoline;200g;Kusol;200G/1KG/5KG;AURORA KA-684;1-AZATETRALIN;AKOS BBS-00003596;1,2,3,4-Tetrahydroqu;1,2,3,4-Hydroquinoline;Py-Tetrahydroquinoline
CBNumber:
CB7286982
Molecular Formula:
C9H11N
Molecular Weight:
133.19
MDL Number:
MFCD00006693
MOL File:
635-46-1.mol
MSDS File:
SDS
Last updated:2024-03-20 19:26:33
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1,2,3,4-Tetrahydroquinoline Properties

Melting point 9-14 °C (lit.)
Boiling point 113-117 °C/10 mmHg (lit.) 249 °C (lit.)
Density 1.061 g/mL at 25 °C (lit.)
refractive index n20/D 1.593(lit.)
Flash point 213 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Liquid
pka 5.09±0.20(Predicted)
color Clear pale yellow to yellow
Odor at 1.00 % in dipropylene glycol. honey civet animal phenolic
PH 10-11 (111g/l, H2O, 20℃)(as an emulsion)
Odor Type animal
Water Solubility <1 g/L (20 ºC)
FreezingPoint 11.0 to 20.0 ℃
BRN 116149
LogP 2.290
CAS DataBase Reference 635-46-1(CAS DataBase Reference)
FDA UNII CCR50N1Z9G
NIST Chemistry Reference Quinoline, 1,2,3,4-tetrahydro-(635-46-1)
EPA Substance Registry System 1,2,3,4-Tetrahydroquinoline (635-46-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H412
Precautionary statements  P264-P270-P273-P301+P310-P405-P501
Hazard Codes  Xi,T
Risk Statements  36/37/38-45
Safety Statements  26-36/37-36-45-53
WGK Germany  3
TSCA  Yes
HS Code  29334990
NFPA 704
1
3 0

1,2,3,4-Tetrahydroquinoline price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 87350 1,2,3,4-Tetrahydroquinoline purum, ≥96.0% (GC) 635-46-1 500ml $108 2024-03-01 Buy
Sigma-Aldrich 87350 1,2,3,4-Tetrahydroquinoline purum, ≥96.0% (GC) 635-46-1 100ml $55.3 2023-06-20 Buy
TCI Chemical T0113 1,2,3,4-Tetrahydroquinoline >95.0%(GC) 635-46-1 25mL $21 2024-03-01 Buy
TCI Chemical T0113 1,2,3,4-Tetrahydroquinoline >95.0%(GC) 635-46-1 100mL $41 2024-03-01 Buy
Alfa Aesar B22750 1,2,3,4-Tetrahydroquinoline, 99% 635-46-1 100g $42.65 2024-03-01 Buy
Product number Packaging Price Buy
87350 500ml $108 Buy
87350 100ml $55.3 Buy
T0113 25mL $21 Buy
T0113 100mL $41 Buy
B22750 100g $42.65 Buy

1,2,3,4-Tetrahydroquinoline Chemical Properties,Uses,Production

Chemical Properties

clear pale yellow to yellow liquid

Uses

1,2,3,4-Tetrahydroquinoline is a reagent used in the synthesis of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamides displaying fungicidal activity.

Definition

ChEBI: A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905
Tetrahedron, 52, p. 1631, 1996 DOI: 10.1016/0040-4020(95)00991-4

Synthesis

1,2,3,4-Tetrahydroquinoline is synthesised using quinoline N-oxide as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: In a 1.5 mL reaction vial, B(C6F5)3 (0.025 mmol, 5.0 mol %) was dissolved in chloroform (0.60 mL), towhich diethylsilane (1.75 mmol, 3.5 equiv) was added. After shaking briefly, quinolines (1a-p, 0.50 mmol, 1.0equiv) was subsequently added to the above catalyst solution under argon atmosphere. The reaction mixturewas stirred at 25-65 oC for 6-24 h for the reaction of 1a-h, and at 25-100 oC for 2-24 h for the reaction of 1i-p,then allowed to cool down to room temperature and concentrated under reduced pressure to give the crudeproduct. This reaction mixture was then treated with 0.25 N HCl ethereal solution (7 mL) and stirred at roomtemperature for 1 h to give the solid residue, which was subsequently washed with ether. The solid residue wasthen dissolved or suspended in MeOH (1.0 mL) and neutralized with Na2CO3·H2O (0.5 g) at 0 oC. After stirringfor 2 h, MeOH was removed under reduced pressure, and the neutralized reaction residue was dissolved inCH2Cl2 and washed with brine (5 mL) and water (5 mL). The crude product was then obtained from the organicphase of CH2Cl2 solution and finally purified by column chromatography on silica gel to give 2a-h(EtOAc/Hexane = 1/9) and 2i-p (EtOAc/Hexane = 3/7).
1,2,3,4-Tetrahydroquinoline synthesis

1,2,3,4-Tetrahydroquinoline Preparation Products And Raw materials

Raw materials

Quinoline Ethylene glycol

Preparation Products

6-Bromoquinoline 7-Amino-1-methyl-1,2,3,4-tetrahydroquinoline 1,2,3,4-Tetrahydro-8-hydroxyquinoline Lilolidine 7-NITRO-QUINOLINE
4-Thiazolecarboxylic acid 1-Piperidinecarboxylic acid, 4-(3,4-dihydro-1(2H)-quinolinyl)-, 1,1-dimethylethyl ester Quinoline, 8-ethyl-1,2,3,4-tetrahydro- 6-iodo-1,2,3,4-tetrahydroquinoline 7-HYDROXY-5-OXO-N-PROPYL-2,3-DIHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLINE-6-CARBOXAMIDE

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1,2,3,4-Tetrahydroquinoline Suppliers

Global( 418)Suppliers
Supplier Tel Email Country ProdList Advantage
Handan Huajun chemicals Co.,Ltd
+86-0310-8166573 +8618630058311 sales@huajunchem.com China 28 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 951 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2141 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Henan Xiangtong Chemical Co., Ltd. 		86-371-61312303 info@hnxtchem.com CHINA 292 58
Supplier Advantage
Handan Huajun chemicals Co.,Ltd
58
Hebei Mojin Biotechnology Co., Ltd 		58
hebei hongtan Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Accela ChemBio Inc. 		58
Xiamen AmoyChem Co., Ltd 		58
Henan Xiangtong Chemical Co., Ltd. 		58

View Lastest Price from 1,2,3,4-Tetrahydroquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3,4-Tetrahydroquinoline pictures 2024-04-26 1,2,3,4-Tetrahydroquinoline
635-46-1
 US $80.00 / kg 1kg 99.9% 500 hebei hongtan Biotechnology Co., Ltd
1,2,3,4-Tetrahydroquinoline pictures 2024-03-28 1,2,3,4-Tetrahydroquinoline
635-46-1
 US $0.00 / kg 25kg 98% Inquiry PNP Biotech Co. Ltd
1,2,3,4-Tetrahydroquinoline pictures 2024-03-03 1,2,3,4-Tetrahydroquinoline
635-46-1
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd

1,2,3,4-Tetrahydroquinoline Spectrum

1,2,3,4-Tetrahydroquinoline(635-46-1)MS1,2,3,4-Tetrahydroquinoline(635-46-1)1HNMR1,2,3,4-Tetrahydroquinoline(635-46-1)13CNMR1,2,3,4-Tetrahydroquinoline(635-46-1)IR11,2,3,4-Tetrahydroquinoline(635-46-1)Raman

635-46-1(1,2,3,4-Tetrahydroquinoline)Related Search:

QUINOLINE SULPHATE Quinclorac Quinhydrone 8-Hydroxyquinoline Isoquinoline
Ethoxyquin 6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE (6-HQ),6-HYDROXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE (6-HQ) Coumarin 339 1,2,3,4-Tetrahydroquinaldine Julolidine
CALYCANTHINE Coumarin 153 6-METHYL-1,2,3,4-TETRAHYDROQUINOLINE 3,4-DIHYDROQUINOLIN-2(1H)-ONE 6-FLUORO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE 99,6-FLUORO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE 99
SULFORHODAMINE 101 8-HYDROXYJULOLIDINE Coumarin 102

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1,2,3,4-Tetrahydroquinoline, 95+% 1-AZATETRALIN 1,2,3,4-TETRAHYDROQUINOLINE 1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE AURORA KA-684 AKOS BBS-00003596 1 2 3 4-TETRAHYDROQUINOLINE 98+% 1,2,3,4-Tetrahydroquinoline99% Quinoline,1,2,3,4-tetrahydro- 1,2,3,4-Hydroquinoline 1,2,3,4-TETRHYDROQUINOLINE 1,2,3,4-Tetrahydrochinoline 1,2,3,4-tetrahydro-quinolin Kusol 1,2,3,4- fourhydrogenation ofquinoline 1,2,3,4-Tetrahydroquinoline puruM, >=96.0% (GC) Py-Tetrahydroquinoline 1,2,3,4-TETRAHYDROQUINOLINE FOR SYNTHESI 1,2,3,4-Tetrahydroqu 1,2,3,4-Tetrahydroquinoline, 98% 100GR 200G/1KG/5KG 1,2,3,4-TetrahydroquinoL 1,2,3,4-Tetrahydroquinoline Solution 1,2,3,4-Tetrahydroquinoline > 1.2.3.4-TETRA-HYDROQUINOLINE [635-46-1 ] 1,2,3,4-Tetrahydroquinoline ISO 9001：2015 REACH Tetrahydroquinoline 200g 635-46-1 635-64-1 635-45-1 Building Blocks AMINE Isoquinolines Heterocyclic Building Blocks Quinolines Building Blocks Chemical Synthesis Heterocyclic Building Blocks Alphabetical Listings Flavors and Fragrances Q-Z Quinoline&Isoquinoline Pyridines Building Blocks Heterocyclic Building Blocks Isoquinolines Quinolines bc0001