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Stattic

CAS No.
19983-44-9
Chemical Name:
Stattic
Synonyms
Stattic;CS-1523;AKOS 1001;15-Methyl-PGF2α;BUTTPARK 97\04-73;STAT3 Inhibitor V;Stattic USP/EP/BP;Stat3 inhibitor V, stattic;Stat three inhibitory compound;15(S)-15-Methyl Prostaglandin F2α
CBNumber:
CB7294835
Molecular Formula:
C8H5NO4S
Molecular Weight:
211.19
MDL Number:
MFCD00173799
MOL File:
19983-44-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

Stattic Properties

Melting point 187-188 °C
Boiling point 461.1±45.0 °C(Predicted)
Density 1.621±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: >20mg/mL
form powder
color white to beige
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-22
Safety Statements  26-36/37/39
WGK Germany  3
Hazard Note  Irritant
HS Code  2934999090
NFPA 704
0
2 0

Stattic price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S7947 Stattic ≥98% (HPLC), powder 19983-44-9 25mg $187 2024-03-01 Buy
Sigma-Aldrich 573099 STAT3 Inhibitor V, Stattic 19983-44-9 25mg $272 2024-03-01 Buy
Cayman Chemical 14590 Stattic ≥98% 19983-44-9 10mg $57 2024-03-01 Buy
Cayman Chemical 14590 Stattic ≥98% 19983-44-9 25mg $117 2024-03-01 Buy
Cayman Chemical 14590 Stattic ≥98% 19983-44-9 50mg $208 2024-03-01 Buy
Product number Packaging Price Buy
S7947 25mg $187 Buy
573099 25mg $272 Buy
14590 10mg $57 Buy
14590 25mg $117 Buy
14590 50mg $208 Buy

Stattic Chemical Properties,Uses,Production

Description

Stattic (19983-44-9) is a STAT3 inhibitor that inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation.1 Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. Alkyates four cysteine residues on STAT3.2 Exhibits potent antitumor activity.3 Protects against angiotensin II-induced vascular dysfunction and hypertension.4?Stattic is an extremely useful tool to probe involvement of STAT3 in cellular signaling.

Uses

Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5

Uses

Stattic is a Stat3 inhibitor which exhibited potent anti-tumor and induced chemo- and radio-sensitivity in nasopharyngeal carcinoma.

Definition

ChEBI: Stattic is a member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma. It has a role as an antineoplastic agent, a STAT3 inhibitor and a radiosensitizing agent. It is a member of 1-benzothiophenes, a C-nitro compound and a sulfone.

Biological Activity

Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Biochem/physiol Actions

Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.2 Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,3 and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.4

storage

+4°C

References

1) Schust et al. (2006), Stattic: a small molecule inhibitor of STAT3 activation and dimerization; Chem. Biol., 13 1235 2) Heidelberger et al. (2013), Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry; Bioorg. Med. Chem. Lett., 23 4719 3) Pan et al. (2013), Stat3 inhibitor Stattic exhibits potent anti-tumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma; PLoS One, 8(1) e54565 4) Johnson et al. (2013), Small-molecules inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertension; Hypertension, 61 437

Stattic Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 153)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Shanghai Safer Pharmaceutical Technology Co., Ltd.
021-31761238 sales@saferph.com CHINA 897 58
Shanghai Gubang New Materail Technology Co. LTD
21-51317962 +8618721305404 16728589@qq.com CHINA 272 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58

View Lastest Price from Stattic manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Stattic pictures 2019-12-23 Stattic
19983-44-9
US $1.00 / ASSAYS 1ASSAYS 97%-99.9% 100kg Career Henan Chemical Co
  • Stattic pictures
  • Stattic
    19983-44-9
  • US $1.00 / ASSAYS
  • 97%-99.9%
  • Career Henan Chemical Co
BUTTPARK 97\04-73 6-NITRO-1H-1LAMBDA6-BENZO[B]THIOPHENE-1,1-DIONE AKOS 1001 6-Nitro-1-benzothiophene 1,1-dioxide 1,1-DIOXO-6-NITROBENZO(B)THIOPHENE 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound Stattic 6-Nitrobenzo[b]thiophene1,1-dioxide Benzo[b]thiophene, 6-nitro-, 1,1-dioxide Stat three inhibitory compound Stat3 inhibitor V, stattic 1,1-Dioxide-6-nitro-benzo[b]thiophene STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem CS-1523 STAT3 Inhibitor V Stattic USP/EP/BP 6-Nitro-benzo[b]thiophen-1,1-dioxid 15(S)-15-Methyl Prostaglandin F2α 15-Methyl-PGF2α 19983-44-9 C8H5NO4S Inhibitors JAK STAT JAK/STAT